Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: A biochemical, histopathological, and electron microscopic evidence

Cell Biochemistry and Function

Volumn 28, Issue 1, 2010, Pages 74-82

  Tanwar, Vineeta ^a   Sachdeva, Jaspreet ^a   Kishore, Kamal ^a   Mittal, Rajan ^b   Nag, Tapas Chandra ^a   Ray, Ruma ^a   Kumari, Santosh ^c   Arya, Dharamvir Singh ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

Author keywords

Curcumin; Isoprenaline; Myocardial necrosis; Pro oxidant; Ultrastructural alterations

Indexed keywords

CREATINE KINASE MB; CURCUMIN; DIMETHYL SULFOXIDE; GLUTATHIONE; ISOPRENALINE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTRON MICROSCOPY; HEART MUSCLE NECROSIS; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

ADMINISTRATION, ORAL; ANIMALS; CREATINE KINASE; CURCUMIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GLUTATHIONE; ISOPROTERENOL; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; MYOCARDIUM; NECROSIS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; CURCUMA LONGA; RATTUS;

EID: 74049148843     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1623     Document Type: Article

References (58)

1. Chugh SS, Reinier K, Teodorescu C, et al. Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis 2008; 51: 213-228.
2. Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. Med Clin North Am 2004; 88: 1209-1235.
3. Walia M, Kwan CY, Grover AK. Effects of free radicals on coronary artery. Med Princ Pract 2003; 12: 1-9.
4. Lefer DJ, Granger DN. Oxidative stress and cardiac disease. Am J Med 2000; 109: 315-323.
5. Bandyopadhyay D, Chattopadhyay A, Ghosh G, Datta AG. Oxidative stress-induced ischemic heart disease: protection by antioxidants. Curr Med Chem 2004; 11: 369-387.
6. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006; 78: 2081-2087.
7. Kalpana C, Menon VP. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. Pol J Pharmacol 2004; 556: 581-586.
8. M Khopde S, Priyadarsini KI, Venkatesan P, Rao MN. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophys Chem 1999; 80: 85-91.
9. Soudamini KK, Unnikrishnan MC, Soni KB, Kuttan R. Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian J Physiol Pharmacol 1992; 36: 239-243.
10. Kuttan G, Kumar KB, Guruvayoorappan C, Kuttan R. Antitumor, antiinvasion, and antimetastatic effects of curcumin. Adv Exp Med Biol 2007; 595: 173-184.
11. Marín YE, Wall BA, Wang S, et al. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res 2007; 17: 274-283.
12. Chen A, Xu J, Johnson AC. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene 2006; 25: 278-287.
13. Garg R, Gupta S, Maru GB. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis 2008; 29: 1022-1032.
14. Polasa K, Naidu AN, Ravindranath I, Krishnaswamy K. Inhibition of B(a)P induced strand breaks in presence of curcumin. Mutat Res 2004; 557: 203-213.
15. Iqbal M, Okazaki Y, Okada S. In vitro curcumin modulates ferric nitrilotriacetate (Fe-NTA) and hydrogen peroxide (H2O2)-induced peroxidation of microsomal membrane lipids and DNA damage. Teratog Carcinog Mutagen 2003; (Suppl 1): 151-160.
16. Yoshino M, Haneda M, Naruse M, et al. Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol In Vitro 2004; 18: 783-789.
17. Kelly MR, Xu J, Alexander KE, Loo G. Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA. Mutat Res 2001; 485: 309-318.
18. Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic Biol Med 2008; 45: 1403-1412.
19. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358.
20. Cabaud PG, Wroblewski F. Colorimetric measurements of lactic dehydrogenase activity of body fluids. Am J Clin Pathol 1958; 30: 234-236.
21. Moron MS, Depierre J, Manmerik B. Level of glutathione, glutathione reductase and glutathione-s-transferase activity in rat lung and liver. Biochem Biophys Acta 1979; 582: 67-78.
22. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-474.
23. Milei J, Nuñez RG, Rapaport M. Pathogenesis of isoprenaline-induced myocardial lesions: its relation to human 'coagulative myocytolysis'. Cardiology 1978; 63: 139-151.
24. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985; 17: 291-306.
25. Todd GL, Baroldi G, Pieper GM, Clayton FC, Eliot RS. Experimental catecholamine-induced myocardial necrosis I. Morphology, quantification and regional distribution of acute contraction band lesions. J Mol Cell Cardiol 1985; 17: 317-338.
26. Yeager JC, Iams SG. The haemodynamics of isoprenaline-induced cardiac failure in rats. Circ Shock 1981; 8: 151-163.
27. Grimm D, Elsner D, Schunkert H, et al. Development of heart failure following isoprenaline administration in the rat: role of the reninangiotensin system. Cardiovasc Res 1998; 37: 91-100.
28. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 2004; 61: 461-470.
29. Nazam Ansari M, Bhandari U, Pillai KK. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol 2007; 26: 933-938.
30. Manikandan P, Sumitra M, Aishwarya S, Manohar BM, Lokanadam B, Puvanakrishnan R. Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int J Biochem Cell Biol 2004; 36: 1967-1980.
31. Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998; 124: 425-427.
32. Nirmala C, Anand S, Puvanakrishnan R. Curcumin treatment modulates collagen metabolism in isoproterenol induced myocardial necrosis in rats. Mol Cell Biochem 1999; 197: 31-37.
33. Nirmala C, Puvanakrishnan R. Effect of curcumin on certain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats. Biochem Pharmacol 1996; 51: 47-51.
34. Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem 1996; 159: 85-93.
35. Cao J, Jia L, Zhou HM, Liu Y, Zhong LF. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci 2006; 91: 476-483.
36. Grant CM. Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 2001; 39: 533-541.
37. Dickinson DA, Iles KE, Zhang H, Blank V, Forman HJ. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J 2003; 17: 473-475.
38. McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int J Mol Med 2007; 19: 165-172.
39. Pugazhenthi S, Akhov L, Selvaraj G, Wang M, Alam J. Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am J Physiol Endocrinol Metab 2007; 293: E645-E655.
40. Priyadarsini KI, Maity DK, Naik GH, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med 2003; 35: 475-484.
41. Anand P, Thomas SG, Kunnumakkara AB, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008; 76: 1590-1611.
42. Scapagnini G, Foresti R, Calabrese V, Giuffrida Stella AM, Green CJ, Motterlini R. Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol Pharmacol 2002; 61: 554-561.
43. Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H, Vajaragupta O. Cytoprotective and cytotoxic effects of curcumin: dual action on H2O2-induced oxidative cell damage in NG108-15 cells. Biol Pharm Bull 2003; 26: 725-728.
44. Santel T, Pflug G, Hemdan NY, et al. Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. PLoS One 2008; 3: 3508.
45. Balasubramanyam M, Koteswari AA, Kumar RS, Monickaraj SF, Maheswari JU, Mohan V. Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J Biosci 2003; 28: 715-721.
46. Mohanty I, Arya DS, Dinda A, Talwar KK, Joshi S, Gupta SK. Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol 2004; 94: 184-190.
47. Sharma M, Kishore K, Gupta SK, Joshi S, Arya DS. Cardioprotective potential of Ocimum sanctum in isoprenaline induced myocardial infarction in rats. Mol Cell Biochem 2001; 225: 75-83.
48. Lin JK. Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. Arch Pharm Res 2004; 27: 683-692.
49. Thangapazham RL, Sharma A, Maheshwari RK. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J 2006; 8: E443-E449.
50. Hong J, Bose M, Ju J, et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives:effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 2004; 25: 1671-1679.
51. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65: 1631-1652.
52. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007; 595: 105-125.
53. Woo JH, Kim YH, Choi YJ, et al. Molecular mechanisms of curcumininduced cytotoxicity: induction of apoptosis through generation of reactive oxygen species,down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-1208.
54. Ligeret H, Barthelemy S, Zini R, Tillement JP, Labidalle S, Morin D. Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore. Free Radic Biol Med 2004; 36: 919-929.
55. 2+ and the activation of caspase-3. Anticancer Res 2006; 26: 4379-4389.
56. Das R, Roy A, Dutta N, Majumder HK. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis 2008; 13: 867-882.
57. Bernardi P, Rasola A. Calcium and cell death: the mitochondrial connection. Subcell Biochem 2007; 45: 481-506.
58. 2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ 2008; 15: 1857-1864.