Mechanisms of Cardioprotective Effect of Withania somnifera in Experimentally Induced Myocardial Infarction

Basic and Clinical Pharmacology and Toxicology

Volumn 94, Issue 4, 2004, Pages 184-190

  Mohanty, Ipseeta ^a   Arya, Dharamvir Singh ^a   Dinda, Amit ^a   Talwar, Keval Kishan ^a   Joshi, Sujata ^a   Gupta, Suresh Kumar ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; CREATINE KINASE; GLUTATHIONE; ISOPRENALINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PHOSPHOTRANSFERASE; SUPEROXIDE DISMUTASE; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART PROTECTION; HEART RATE; HEMODYNAMICS; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; WITHANIA;

ANIMALIA; WITHANIA; WITHANIA SOMNIFERA;

EID: 1942469898     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.pto940405.x     Document Type: Article

References (33)

1. Aebi, H.: Catalase. In: Methods of enzymatic analysis. Hans Elrich Bergmayer. Edition II. Vol. 2, 1974.
2. Andallu, B. & B. Radhika: Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry roots. Indian J. Exp. Biol. 2000, 38, 607-609.
3. Archana, R. & A. Namasivayam: Antistressor effect of Withania somnifera. J. Ethnopharmacol. 1999, 64, 91-93.
4. Bhattacharya, S. K., K. S. Satyan & S. Ghosal: Antioxidant activity of Bacopa monniera in rat frontal cortex, straitum and hippocampus. Phytotherapy Res. 2000, 14, 174-179.
5. Bolli, R.: Myocardial ischemic metabolic disorder leading to cell death. Rev. Post. Cardiol. 1994, 13, 649-653.
6. Burton, K. P., J. M. McCord & G. Ghai: Myocadial alteration due to free radical generation. Amer. J. Physiol. 1984, 84, H776-783.
7. Caband, P. G. & F. Wroblewski: Calorimetric measurements of lactic dehydrogenase activity of body fluids. Amer. J. Clin. Path. 1958, 3, 234-236.
8. Csapo, Z., J. Dusek & G. Rano: Early alterations of the cardiac muscle cells in isoproterenol induced necrosis. Arch. Pathol. 1972, 93, 356-365.
9. Devi, P. U. & A. Ganasoundari: Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J. Exp. Biol. 1999, 37, 162-168.
10. Dhar, M. L., M. M. Dhar, B. N. Dhawan, B. N. Mehrotra & C. Ray: Screening of Indian plants for biological activity. J. Exp. Biol. 1968, 6, 232-247.
11. Dhuley, J. N.: Adaptogenic and cardioprotective action of ashwagandha on rats and frogs. J. Ethnopharmacol. 2000, 70, 57-63.
12. Dinda, A. K., S. Guleria, S. Tiwari, S. C. Dash & A. Bagga: Dignosis of glomerular haematuria by image cytometry of urinary red cells. Nephron. 2001, 88, 93-99.
13. Dormandy, T. L.: Free radical oxidation and antioxidants. Lancet 1978, 1, 647-650.
14. Haenen, G. R., M. Veerman & A. Bast: Reduction of beta-adrenoceptor function by oxidative stress in the heart. Free Radic. Biol. Med. 1990, 9, 279-288.
15. Handforth, C. P.: Isoproterenol-induced myocardial infarction in animals. Arch. Pathol. 1962, 73, 161-165.
16. Kaushal, J. K., M. Chawla & R. Sharma (Eds.): In: Heart and Herbs. Pub. Vedic Research Centre. 2000.
17. Hertog, M. G. L., E. J. M. Feskens, P. C. H. Hollam, M. B. Katan & D. Kromhout: Dietary antioxidant flavonoids and risk of coronary heart diseases. The Zutphen Elderly Study. Lancet 1993, 342, 1007-1020.
18. Jennings, R. B., C. E. Murry, C. J. R. Steenbergen & K. A. Reimer: Acute myocardial ischemia: development of cell injury in sustained ischemia. Circulation 1990, 82, 3-12.
19. Kaul, N., L. H. Siveski, M. Hill, J. Slezak & P. K. Singal: Free radicals and the heart. J. Pharmacol. Toxicol. Method. 1993, 20, 55-57.
20. Kulkarni, R. R., P. S. Patki, V. P. Jog, S. G. Gandage & B. Parvardhan: Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo controlled, cross over study. J. Ethanopharmacol. 1991, 33, 91-95.
21. Lamprecht, W., F. Stan, H. Weisser & F. Heinz: Determination of creatine phosphate and adenosine triphosphate with creatine kinase. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Academic Press, NY, 1974, 1776-1778.
22. Lavie, D., E. Glotter & Y. Shro: Constituents of Withania somnifera. Dun IV. J Chem. Soc. 1965, 12, 7517.
23. Lei, X. L. & G. C. Chiou: Cardiovascular pharmacology of Panax notoginseng (Burk) F. H. Chen and Salvia miltiorrhiza. Amer. J. China Med. 1986, 14, 145-152.
24. Lowry, O. H., N. J. Rosebrough & A. I. Farr: Protein measurements with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
25. Malhotra, C. L., K. S. Prasad, P. K. Das & N. S. Dhalla: Studies on Withania somnifera (Part III). The effect of total alkaloid (ashwagandholine) on CVS and respiration. Ind. J. Med. Res. 1961, 49, 449.
26. Maron, M. S., J. W. Depierre & B. Manmerik: Level of glutathione, glutathione reductase and glutathione-s-transferase activity in rat lung and liver. Biochim. Biophys. Acta 1979, 82, 67-78.
27. Mishra, H. P. & I. Fridovich: The oxidation of phenylhydrazine: superoxide and mechanisms. Biochemistry 1976, 15, 681-687.
28. Nirmala, C. & R. Puvanakrishnan: Isoproterenol induced myocardial infarction in rats: functional and biochemical alterations. Med. Sci. Res. 1994, 22, 575-577.
29. Noronha-Dutra, A. A., E. M. Steen & N. Woolf: The correlation between catecholamine and lipid peroxidation induced in heart cells. Basic Res. Cardiol. 1984, 80, 133-136.
30. Ohkawa, H., N. Ohishi & K. Yagi: Assay of lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 1979, 95, 351-358.
31. Paglia, D. E. & W. N. Valentine: Studies on the quantitative and qualitative characterization of erythrocyte peroxidase. J. Lab. Clin. Med. 1967, 2, 158.
32. Singal, P. K., R. E. Beamish & N. S. Dhalla: Potential oxidative pathways of catecholamines in the formation of lipid peroxides and heart disease. Adv. Exp. Med. Biol. 1983, 161, 391-401.
33. 2+ transport Arch. Biochem. Biophys. 2001, 377, 85-92.