Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation

Journal of Biological Chemistry

Volumn 285, Issue 2, 2010, Pages 1177-1187

  Xiao, Zhousheng ^a   Zhang, Shiqin ^a   Cao, Li ^a   Qiu, Ni ^a   David, Valentin ^a   Quarles, L Darryl ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENESIS; BONE FORMATION; BONE MARROW; BONE MINERAL DENSITY; BONE SIALOPROTEINS; CATENIN SIGNALING; CELL TYPES; CORTICAL THICKNESS; DISEASE-CAUSING GENE; DOSE-DEPENDENT; MINERAL APPOSITION RATE; OSTEOBLAST CULTURES; OSTEOBLASTIC FUNCTIONS; OSTEOCALCIN; OSTEOPENIA; OSTEOPONTIN; POLYCYSTIN; SKELETAL DEVELOPMENT; TRABECULAR BONES;

BONE; CELL CULTURE; SILICATE MINERALS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

OSTEOBLASTS;

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; OSTEOCALCIN; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCYSTIN 1; PROTEIN KINASE B; SIALOPROTEIN; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DENSITOMETRY; BONE DENSITY; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENETIC TRANSFECTION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; OSTEOPENIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRABECULAR BONE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA CATENIN; BONE AND BONES; BONE DENSITY; BONE DISEASES, METABOLIC; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CROSSES, GENETIC; GENE DELETION; GENE DOSAGE; GLYCOGEN SYNTHASE KINASE 3; MICE; MICE, TRANSGENIC; ONCOGENE PROTEIN V-AKT; ORGAN SIZE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; SIGNAL TRANSDUCTION; TRPP CATION CHANNELS;

MUS;

EID: 74049138304     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.050906     Document Type: Article

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