Local Ca2+ signaling and EC coupling in heart: Ca2+ sparks and the regulation of the [Ca2+]i transient

Journal of Molecular and Cellular Cardiology

Volumn 34, Issue 8, 2002, Pages 941-950

  Guatimosim, Silvia ^a   Dilly, Keith ^a   Ferno Santana, L ^b   Saleet Jafri, M ^c   Sobie, Eric A ^a   Lederer, W J ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF DALLAS   (United States)

Author keywords

Action potential prolongation; Arrhythmia; Ca2+ channels; Calcium sparks; Cardiac ventricular myocytes; Coupled gating; DHPR; EC coupling; Excitation contraction coupling; FK binding proteins; Heart failure; Potassium channels; Sparks

Indexed keywords

CALCIUM; RYANODINE RECEPTOR;

CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; DIASTOLE; EXCITATION CONTRACTION COUPLING; HEART; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HUMAN; PRIORITY JOURNAL; REVIEW; SARCOPLASMIC RETICULUM;

EID: 0036702790     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2002.2032     Document Type: Review

References (44)

1. Choi HS, Eisner DA. The effects of inhibition of the sarcolemmal Ca-ATPase on systolic calcium fluxes and intracellular calcium concentration in rat ventricular myocytes [In Process Citation]. Pflügers Archiv European J Physiol 1999; 437: 966-971.
2. 2+) release units and couplons in skeletal and cardiac muscles. Biophys J 1999; 77: 1528-1539.
3. 2+ sequestration [In Process Citation]. Ann NY Acad Sci 1998; 853: 341-344.
4. +-ATPase of the sarcoplasmic reticulum in adult rat papillary muscle. J Cell Biol 1982; 93: 883-892.
5. Cheng H, Lederer WJ, Cannell MB. Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle. Science 1993; 262: 740-744.
6. Lipp P, Niggli E. Submicroscopic calcium signals as fundamental events of EC-coupling in guinea pig cardiac myocytes. J Physiol 1996.
7. Protasi F, Takekura H, Wang Y, Chen SR, Meissner G, Allen PD, Franzini-Armstrong C. RYR1 and RYR3 have different roles in the assembly of calcium release units of skeletal muscle [In Process Citation]. Biophys J 2000; 79: 2494-2508.
8. Franzini-Armstrong C. The sarcoplasmic reticulum and the control of muscle contraction [In Process Citation]. FASEB J 1999; 13(Suppl 2): S266-S270.
9. Sharma MR, Penczek P, Grassucci R, Xin HB. Fleischer S, Wagenknecht T. Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor. J Biol Chem 1998; 273: 18429-18434.
10. Samso M. Wagenknecht T. Contributions of electron microscopy and single-particle techniques to the determination of the ryanodine receptor three-dimensional structure. J Struct Biol 1998; 121: 172-180.
11. Wagenknecht T, Badermacher M, Grassucci R, Berkowitz J, Xin HB, Fleischer S. Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. J Biol Chem 1997; 272: 32463-32471.
12. Gaburjakova M, Gaburjakova J, Reiken S, Huang F, Marx SO, Rosemblit N, Marks AR. FKBP12 binding modulates ryanodine receptor channel gating. J Biol Chem 2001;
13. Marx SO, Gaburjakova J, Gaburjakova M, Henrikson C, Ondrias K, Marks AR. Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res 2001; 88: 1151-1158.
14. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts. Cell 2000; 101: 365-376.
15. Ondrias K, Marx SO, Gaburjakova M, Marks AR. FKBP12 modulates gating of the ryanodine receptor/calcium release channel. Ann NY Acad Sci 1998; 853: 149-156.
16. Smith GD. Keizer JE, Stern MD, Lederer WJ, Cheng H. A simple numerical model of calcium spark formation and detection in cardiac myocytes. Biophys J 1998; 75: 15-32.
17. 2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions. J Gen Physiol 1999; 113: 177-186.
18. 2+ release channels (ryanodine receptors) [see Comments]. Science 1998; 281: 818-821.
19. i waves in cardiac myocytes. Am J Physiol 1996; 270: C148-C159.
20. 2+ sensing sites. Biophys J 1998; 75: 2801-2810.
21. 2+ sparks. Biophys J 2001; 80: 2666.
22. Jafri MS, Sobie E, Lederer WJ. Modeling the effects of sarcoplasmic reticulum lumenal and subspace calcium on spontaneous spark rate in cardiac myocytes. Biophys J 2002; 82: 281a.
23. 2+ spark shape. Biophys J 2002; 82: 73a.
24. Santana LF, Kranias EG, Lederer WJ. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J Physiol (Lond) 1997; 503 (Pt 1): 21-29.
25. 2+ sensing sites [In Process Citation]. Biophys J 1998; 75: 2801-2810.
26. Kass RS, Tsien RW, Weingart R. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol (Lond) 1978; 281: 209-226.
27. Kass RS, Lederer WJ, Tsien RW, Weingart R. Role of calcium ions in transient inward currents and after-contractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol (Lond) 1978; 281: 187-208.
28. Lederer WJ, Tsien RW. Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibers. J Physiol 1976; 263: 73-100.
29. Berlin JR, Cannell MB, Lederer WJ. Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium. Circ Res 1989; 65: 115-126.
30. Clusin WT. Caffeine induce a transient inward current in cultured cardiac cells. Nature 1983; 301: 248-250.
31. Lipp P, Pott L. Voltage dependence of sodium-calcium exchange current in guinea-pig atrial myocytes determined by means of an inhibitor. J Physiol (Lond) 1988; 403: 355-366.
32. Bassani RA, Bers DM. Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes. Biophys J 1995; 68: 2015-2022.
33. Santana LF, Kranias EG, Lederer WJ. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J Phys 1997; 503: 21-29.
34. Cannell MB, Cheng H, Lederer WJ. The control of calcium release in heart muscle. Science 1995; 268: 1045-1050.
35. 2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res 1996; 78: 166-171.
36. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure [see Comments]. Science 1997; 276: 800-806.
37. i transients in mouse ventricular myocytes. Biophys J 2001; 80: 1230-1237.
38. Kass RS, Tsien RW, Weingart R. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol 1978; 281: 209-226.
39. Eisner DA, Lederer WJ. Inotropic and arrhythmogenic effects of potassium-depleted solutions on mammalian cardiac muscle. J Physiol 1979; 294: 255-277.
40. i waves in cardiac myocytes. Am J Physiol: Cell Physiol 1996; 270: C148-C159.
41. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Lederer WJ, Kandolf R, Knowlton KU. Transgenic expression of replication-restricted enter-oviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest 1998; 102: 1444-1453.
42. Esposito G, Santana LF, Dilly K, Cruz JD, Mao L, Lederer WJ, Rockman HA, Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol 2000; 279: H3101-H3112.
43. Gomez AM, Guatimosim S, Dilly KW, Vassort G, Lederer WJ. Heart failure after myocardial infarction: Altered excitation-contraction coupling. Circulation 2001; 104: 688-693.
44. 2+-sparks. Cell Calcium 1996; 20: 129-140.