Perspectives on mammalian cardiovascular aging: Humans to molecules

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 132, Issue 4, 2002, Pages 699-721

  Lakatta, Edward G ^a   Sollott, Steven J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Heart; Mammals; Stress response; Vasculature

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; REACTIVE OXYGEN METABOLITE; BETA ADRENERGIC RECEPTOR; MEMBRANE LIPID;

ADRENERGIC SYSTEM; AGING; CALCIUM CURRENT; CARDIOVASCULAR FUNCTION; CELL COUNT; CELL DAMAGE; CONFERENCE PAPER; EXCITATION CONTRACTION COUPLING; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; HEART AFTERLOAD; HEART CONTRACTION; HEART DILATATION; HEART EXCITATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FILLING; HEART MITOCHONDRION; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HUMAN; NONHUMAN; POTASSIUM CURRENT; PROTEIN FUNCTION; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; ADULT; AGED; ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CARDIOVASCULAR SYSTEM; HEART LEFT VENTRICLE FUNCTION; LIPID PEROXIDATION; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REVIEW; STRESS;

MAMMALIA; RODENTIA;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; CALCIUM SIGNALING; CARDIOVASCULAR PHYSIOLOGY; CARDIOVASCULAR SYSTEM; HUMANS; LIPID PEROXIDATION; MEMBRANE LIPIDS; MIDDLE AGED; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA; STRESS; VENTRICULAR FUNCTION, LEFT;

EID: 0036018450     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-6433(02)00124-1     Document Type: Conference Paper

References (116)

1. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow
2. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart
3. TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop
4. Non synchronous changes in myocardial collagen mRNA and protein during aging Effect of DOCA-salt hypertension
5. Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids
6. 4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium
7. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids
8. Effects of exercise on myocardial adenylate cyclase and Gia expression in senescence
9. Age-associated increase in rat cardiac opioid production
10. Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart
11. Cardiovascular Aging in Health
12. Transforming growth factor-β in disease: The dark side of tissue repair
13. Left atrial performance indices in chronic mitral valve disease
14. Age-dependent changes in the β-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium
15. Aging, Cardiac Proenkephalin mRNA and Enkephalin Peptides in the Fisher 344 Rat
16. Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts
17. Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat
18. Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate
19. Thyroid hormone influences beta myosin heavy chain (βMHC) expression.
20. Changes in myosin isoenzymes, ATPase activity, and contraction duration in rat cardiac muscle with aging can be modulated by thyroxine
21. Collagen accumulation in heart ventricles as a function of growth and aging
22. Aging effects on human sympathetic neuronal function
23. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
24. 2+-ATPase gene required for expression in cardiac muscle cells
25. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women
26. Role of the extracellular matrix in age-related modifications of the rat aorta
27. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
28. Studies of sarcoplasmic reticulum function and contraction duration in young and aged rat myocardium
29. Chemiluminescent real time imaging of post-ischemic oxygen free radicals formation in livers isolated from young and old rats
30. Echocardiographic assessment of a normal adult aging population
31. Analysis of thyroid hormone effects on myosin heavy chain gene expression in cardiac and soleus muscles using a novel dot-blot mRNA assay
32. Comparison of aortic intima and inner media in young adult vs. aging rats
33. Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids
34. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury in the heart
35. Bioenergetics in aging
36. Aging and atherosclerosis. I Development of myointimal hyperplasmia after endothelial cells injury
37. Aortic endothelial and subendothelial cells in experimental hypertension and aging
38. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-κB transcription factor in mouse cardiac muscle
39. Inhibition of NADH-linked mitochondrialrespiration by 4-hydroxy-2-nonenal
40. Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myofibrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle
41. Necrotic and apopotic myocyte cell death in the aging heart of Fischer 344 rats
42. Cardiovascular effects of aging. Interrelationships of aortic, left ventricular, and left atrial function
43. Hormonal modulation of a gene injected into rat heart in vivo
44. Diminished inotropic response of aged myocardium to catecholamines
45. Myocardial aging: Functional alterations and related cellular mechanisms
46. Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans (point of view)
47. Cardiovascular regulatory mechanisms in advanced age
48. Aging of the cardiovascular system
49. The old heart: Operating on the edge
50. Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements
51. Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats
52. Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to senescent mouse cardiomyocyte
53. 2+-ATPase and calsequestrin genes in rat heart during ontogenic development and aging
54. Myocardial retinoid X receptor, thyroid hormone receptor, and myosin heavy chain gene expression in the rat during adult aging
55. Cardiac reperfusion injury, Aging, lipid peroxidation, and mitochondrial dysfunction
56. Declines in mitochondrial respiration during cardiac reperfusion: Age-dependent inactivation of a-ketoglutarate dehydrogenase
57. Production of transforming growth factor β1 during repair of arterial injury
58. Age-related changes in fibronectin expression in spontaneously hypertensive. Wistar-Kyoto, and Wistar rat hearts
59. Evidence for an age-associated dyfunction in the antiproliferative response to transforming growth factor-β in vascular smooth muscle cells
60. 5] enkephalin
61. Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion
62. Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids
63. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey
64. The influence of age and dietary fat in animal model of sudden cardiac death
65. Influence of dietary lipids on arrhythmia and infarction after coronary artery ligation in rats
66. Decrease in the rate of RNA and protein synthesis and degradation in the myocardium under long-term compensatory hyperfunction and on aging
67. Effect of chronic ANG I-converting enzyme inhibition on aging processes. II. Large arteries
68. Differential expression of metalloproteinase and tissue inhibitor of metaproteinase genes in aged human fibroblasts
69. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
70. Diminished heat shock protein 70 mRNA induction in aged rat hearts after ischemia
71. Influence of mitochondrial radical formation on energy-linked respiration
72. Gender differences and Aging: Effects in the human heart
73. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy
74. Intracellular calcium transients and developed tensions in rat heart muscle. A mechanism for the negative interval-strength relationship
75. Cardiac adenylyl cyclase regulation by opioid and adrenergic signal interactions
76. 2+, and contraction in adult rat cardiac myocytes
77. 2+ activation of PDH
78. 2+ exchange and calcium permeability of cardiac sarcoplasmic reticulum vesicles
79. Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restrictions
80. Basal and stimulated plasma atrial natriuretic peptide (ANP) concentrations and cardiac ANP contents in old and young rats
81. Aging of the vascular wall and atherogenesis: Role of the elastin-laminin receptor
82. 2+ATPase and myosin heavy chain a gene expression in cardiac myocytes
83. Cardiac performance in the unanesthetized senescent male rat
84. Rapamyocin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro: Potential role of 70 kD S6 kinase in angiotensin II - Induced cardiac hypertrophy
85. Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes
86. Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat
87. Forskolin activation of adenylate cyclase in rat myocardium with age: Effects of guanine nucleotide analogs
88. Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase
89. Human 92- and 72-kilodalton type IV collagenase are elastases
90. Effects of age on c-fos and c-myc gene expression in response to hemodynamic stress in isolated, perfused rat hearts
91. Effects of age, sex, and breeding status on the rat heart
92. Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding
93. Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species
94. Chronic exercise prevents characteristics age-related changes in rat cardiac contraction
95. 2+ATPase of mouse cardiac sarcoplasmic reticulum is affected by membrane n-6 and n-3 polyunsaturated fatty acid content
96. The calcium uptake of the rat heart sarcoplasmic reticulum is latered by dietary lipid
97. Effect of hypertension on fibronectin expression in the rat aorta
98. Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium
99. SERCA2a and mitochondrial cytochrome oxidase expression are increased in hearts of exercise-trained old rats
100. Effects of age and aerobic capacity on arterial stiffness in healthy adults
101. 2+ release from an intracellular pool in myocytes and neurons
102. Excitation-contraction in rat myocardium: Alterations with adult aging
103. Resting and active mechanical properties of trabeculae carneae from aged male rats
104. Age-related changes in β-adrenergic neuroeffector systems in the human heart
105. Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features
106. Mechanisms of altered β-adrenergic modulation of the cardiovascular system with aging
107. Age-associated changes in β-adrenergic modulation on rat cardiac excitation-contraction coupling
108. 2- adrenoceptor responses without changes in inhibitory G proteins or receptor kinases
109. Use of tibal length to quantify cardiac hypertrophy: Application in the aging rat
110. Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor auxiliary protein heterodimers
111. Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding
112. Age- associated alterations in artial natriuretic factor gene expression in rat
113. Age-associated reduction in recovery of the equilibrium state of myocyte length during reduced interstimulus intervals at higher stimulation rates
114. 2-adrenergic modulation of cardiac excitation-contraction coupling
115. Reactive Oxygen Species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes