Solid lipid microparticles produced by spray congealing: Influence of the atomizer on microparticle characteristics and mathematical modeling of the drug release

Journal of Pharmaceutical Sciences

Volumn 99, Issue 2, 2010, Pages 916-931

  Passerini, Nadia ^a   Qi, Sheng ^b   Albertini, Beatrice ^a   Grassi, Mario ^c   Rodriguez, Lorenzo ^a   Craig, Duncan Q M ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Atomizer; In vitro release; Mathematical model; Solid lipid microparticles; Spray congealing

Indexed keywords

CRYSTALLIN; DRUG CARRIER; GLYCEROL BEHENATE; LIPID; SOLID LIPID MICROPARTICLE; THEOPHYLLINE; UNCLASSIFIED DRUG;

AIR PRESSURE NOZZLE; ARTICLE; ATMOSPHERIC PRESSURE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; ENCAPSULATION; HOT STAGE MICROSCOPY; INFRARED SPECTROSCOPY; MATHEMATICAL MODEL; MICROSCOPY; MORPHOLOGY; NEBULIZATION; NEBULIZER; PARTICLE SIZE; PHYSICAL CHEMISTRY; PREDICTION; PRODUCTIVITY; SPRAY CONGEALING; WIDE PNEUMATIC NOZZLE; X RAY POWDER DIFFRACTION;

EID: 74049128678     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21854     Document Type: Article

References (29)

1. Jaspart S, Piel G, Delattre L, Evrard B. 2005. Solid lipid microparticles: Formulation, preparation, characterisation, drug release and applications. Expert Opin Drug Deliv 2:75-87.
2. Killeen MJ. 1996. Spray drying and spray congealing of pharmaceutics. In: Swarbrick J, Boylan J, editors. Encyclopedia of pharmaceutical technology. New York: Marcel Dekker. pp. 207-221.
3. Yajima T, Umeki N, Itai S. 1999. Optimum spray congealing conditions for masking the bitter taste of clarithomycin in wax matrix. Chem Pharm Bull 47: 220-225.
4. Qi S, Deutsch D, Craig DQM. 2006. An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis. J Pharm Sci 95:1022-1028.
5. Qi S, Deutsch D, Craig DQM. 2008. An investigation into the mechanisms of drug release from taste-masking fatty acid microspheres. J Pharm Sci 97:3842-3854.
6. Rodriguez L, Passerini N, Cavallari C, Cini M, Sancin P, Fini A. 1999. Description and preliminary evaluation of a new ultrasonic atomizer for spraycongealing processes. Int J Pharm 183:133-143.
7. Passerini N, Perissutti B, Moneghini M, Voinovich D, Albertini B, Cavallari C, Rodriguez L. 2002. Characterization of carbamazepine-Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds. J Pharm Sci 91:699-707.
8. Cavallari C, Rodriguez L, Alberini B, Passerini N, Rosetti F, Fini A. 2005. Thermal and fractal analysis of diclofenac/Gelucire 50/13 microparticles obtained by ultrasound-assisted atomization. J Pharm Sci 94:1124-1134.
9. Passerini N, Albertini B, Perissutti B, Rodriguez L. 2006. Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel. Int J Pharm 318:92-102.
10. Savolainen M, Khoo C, Glad H, Dahlqvist C, Juppo AM. 2002. Evaluation of controlled-release polar lipid microparticles. Int J Pharm 244:151-161.
11. Savolainen M, Herder J, Khoo C, Lovqvist K, Dahlqvist C, Glad H, Juppo AM. 2003. Evaluation of polar lipid-hydrophilic polymer microparticles. Int J Pharm 262:47-62.
12. Passerini N, Perissutti B, Albertini B, Voinovich D, Moneghini M, Rodriguez L. 2003. Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing. J Control Release 88:263-275.
13. Albertini B, Passerini N, Gonzalez-Rodriguez ML, Perissutti B, Rodriguez L. 2004. Effect of aerosil on the properties of lipid controlled release microparticles. J Control Release 100:233-246.
14. Maschke A, Becker C, Eyrich D, Kiermaier J, Blunk T, Gopferich A. 2007. Development of a spray congealing process for the preparation of insulinloaded lipid microparticles and characterization thereof. Eur J Pharm Biopharm 65:175-187.
15. Deng JP, Li L, Tian Y, Ginsburg E, Widman M, Myers A. 2003. In vitro characterization of polyorthoester microparticles containing bupivacaine. Pharm Dev Technol 8:31-38.
16. Li LC, Zhu L, Song JF, Deng JS, Bandopadhyay R, Wurster DE. 2005. Effect of solid state transition on the physical stability of suspension containing bupivacaine lipid microparticles. Pharm Dev Technol 10:309-318.
17. McCarron PA, Donnelly RF, Al-Kassas R. 2008. Comparison of a novel spray congealing procedure with emulsion-based methods for the microencapsulation of water-soluble drugs in low melting point triglycerides. J Microencapsul 25:355-378.
18. Albertini B, Mezzena M, Passerini N, Rodriguez L, Scalia S. 2008. Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzone. J Pharm Sci. DOI: 10.1002/jps.21636.1.
19. Passerini N, Gavini E, Albertini B, Rassu G, Di Sabatino M, Sanna V, Giunchedi P, Rodriguez L. 2009. Evaluation of solid lipid microparticles produced by spray congealing for econazole nitrate topical application. J Pharm Pharmacol 61:559-567.
20. Albertini B, Passerini N, Di Sabatino M, Vitali B, Brigidi P, Rodriguez L. 2009. Polymer-lipid based mucoadhesive microspheres prepared by spray congealing for the vaginal delivery of econazole nitrate. Eur J Pharm Sci 36:591-601.
21. Albertini B, Passerini N, Pattarino F, Rodriguez L. 2008. New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances. Eur J Pharm Biopharm 69: 348-357.
22. Grassi M, Grassi G, Lapasin R, Colombo I. 2007. Understanding drug release and absorption mechanisms: A physical and mathematical approach. Boca Raton, FL, USA: CRC Press. pp. 1-627.
23. Higuchi WI, Mir NA, Desai SJ. 1965. Dissolution rates of polyphase mixtures. J Pharm Sci 54:1405-1410.
24. Levich VG. 1962. Physicochemical Hydrodynamics. Englewood Cliffs, NJ: Prentice-Hall.
25. Patankar SV. 1990. Numerical heat transfer and fluid flow. New York: McGraw-Hill/Hemisphere Publishing Corporation.
26. Brubach JB, Jannin V, Mahler B, Bourgaux C, Lessieur P, Roy P, Ollivon D. 2007. Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy. Int J Pharm 336: 248-256.
27. Souto EB, Mehnert W, Muller RH. 2006. Polymorphic behaviour of Compritol 888 ATO as bulk lipid and as SLN and NLC. J Microencapsul 23: 417-433.
28. Craig DQM. 2002. The mechanisms of drug release from solid dispersion in water-soluble polymers. Int J Pharm 231:131-144.
29. Airaksinen S, Karjalainen M, Rasanen E, Rantanen J, Yliruusi J. 2004. Comparison of the effects of two drying methods on polymorphism of theophylline. Int J Pharm 276:129-141.