Effect of solid state transition on the physical stability of suspensions containing bupivacaine lipid microparticles

Pharmaceutical Development and Technology

Volumn 10, Issue 2, 2005, Pages 309-318

  Luk, Chiu Li ^a   Zhu, Lihua ^b   Song, Jing Feng ^a   Deng, Jone Shin ^b   Bandopadhyay, Rubi ^c   Wurster, Dale E ^c  

^a ABBOTT LABORATORIES   (United States)

^b Hospira Inc   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Bupivacaine; Gelation; Heat of dissolution; Lipid microparticles; Phase transition; Suspension; Tristearin

Indexed keywords

BUPIVACAINE; TRISTEARIN;

AQUEOUS SOLUTION; ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; GELATION; HEATING; PHASE TRANSITION; POSTOPERATIVE PAIN; PRIORITY JOURNAL; ROOM TEMPERATURE; SOLID STATE; SUSPENSION; SUSTAINED RELEASE FORMULATION; X RAY POWDER DIFFRACTION;

ANESTHETICS, LOCAL; BUPIVACAINE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; DRUG STABILITY; EXCIPIENTS; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; SUSPENSIONS; TRIGLYCERIDES; X-RAY DIFFRACTION;

EID: 18744397211     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-200054475     Document Type: Article

References (8)

1. Physician Desk's Reference, 56th Ed.; Medical Economics: Montvale, NJ, 2002.
2. Malinovsky, J.; Bernard, J.; Le Corre, P.; Dumand, J.; Lepage, J.; Le Verge, R.; Souron, R. Motor and blood pressure effects of epidural sustained-release bupivacaine from polymer microspheres: a dose-response study in rabbits. Anesth. Analg. 1995, 81, 519-524.
3. Masters, D.; Berde, C.; Dutta, S.; Griggs, C.; Hu, D.; Kupsky, W.; Langer, R. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology 1993, 79, 340-346.
4. Kopacz, D.; Bernards, C.; Allen, H.; Landau, C.; Nandy, P.; Wu, D.; Lacouture, P. A method to evaluate the pharmacokinetic and pharmacodynamic variables of extended-release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules. Anesth. Analg. 2003, 97, 124-131.
5. Malinovsky, J.; Benhamou, D.; Alafandy, M.; Mussini, J.; Coussaert, C.; Couarraze, G.; Pinaud, M.; Legros, F. Neurotoxicological assessment after intracisternal injection of liposomal bupivacaine in rabbits. Anesth. Analg. 1997, 85, 1331-1336.
6. Malinovsky, J.; Le Corre, P.; Meunier, J.; Chevanne, F.; Pinaud, M.; Leverge, R.; Legros, F. A dose-response study of epidural liposomal bupivacaine in rabbits. J. Control. Release 1999, 60, 111-119.
7. Domb, A. Liposphere Delivery Systems for Local Anesthetics. US Patent 5,227,165, 1993.
8. Oh, J.-H.; McCurdy, A.R.; Clark, S.; Swanson, B.G. Characterization and thermal stability of polymorphic forms of synthesized tristearin. J. Food Sci. 2002, 67 (8), 2911-2971.