메뉴 건너뛰기




Volumn 2, Issue 1, 2005, Pages 75-87

Solid lipid microparticles: Formulation, preparation, characterisation, drug release and applications

Author keywords

Administration routes; Characterisation; Drug loading; Drug release; Preparation; Solid lipid microparticles

Indexed keywords

ARGINYLLYSYLASPARTYLVALINE; CARBAMAZEPINE; CYCLODEXTRIN; DODECYL SULFATE SODIUM; DRUG CARRIER; ESTRADIOL; FENBUFEN; FLUOROURACIL; GLYCEROL BEHENATE; GONADORELIN; HYDROCORTISONE; IBUPROFEN; INDOMETACIN; INSULIN; KETOPROFEN; LUTROL; MEDROXYPROGESTERONE ACETATE; PEPTIDE DERIVATIVE; PHOSPHATIDYLCHOLINE; PIRIBEDIL; POLOXAMER; POLYMER; POLYSORBATE 40; POLYSORBATE 80; POLYVINYL ALCOHOL; PSEUDOEPHEDRINE; SOLID LIPID MICROPARTICLE; SOLID LIPID NANOPARTICLE; TEGAFUR; THEOPHYLLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 12344288007     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.2.1.75     Document Type: Review
Times cited : (163)

References (70)
  • 1
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • MEHNERT W, MADER K: Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. (2001) 47:165-196.
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , pp. 165-196
    • Mehnert, W.1    Mader, K.2
  • 3
    • 0034193310 scopus 로고    scopus 로고
    • Therapeutic applications of colloidal drug carriers
    • BARRATT GM: Therapeutic applications of colloidal drug carriers. Pharm. Sci. Tecchnol Today (2000) 3(5):163-171.
    • (2000) Pharm. Sci. Tecchnol Today , vol.3 , Issue.5 , pp. 163-171
    • Barratt, G.M.1
  • 4
    • 0030795298 scopus 로고    scopus 로고
    • Liposomes in drug delivery: Progress and limitations
    • SHARMA A, SHARMA US: Liposomes in drug delivery: Progress and limitations. Int. J. Pharm. (1997) 154(2):123-140.
    • (1997) Int. J. Pharm. , vol.154 , Issue.2 , pp. 123-140
    • Sharma, A.1    Sharma, U.S.2
  • 5
    • 0347651897 scopus 로고    scopus 로고
    • Stability and transdermal absorption of topical amphotericin B liposome formulations
    • MANOSROI A, KONGKANERAMIT L, MANOSROI J: Stability and transdermal absorption of topical amphotericin B liposome formulations. Int. J. Pharm. (2004) 270(1-2):279-286.
    • (2004) Int. J. Pharm. , vol.270 , Issue.1-2 , pp. 279-286
    • Manosroi, A.1    Kongkaneramit, L.2    Manosroi, J.3
  • 6
    • 0028837083 scopus 로고
    • Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
    • BRANNON-PEPPAS L: Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int. J. Pharm. (1995) 116(1):1-9.
    • (1995) Int. J. Pharm. , vol.116 , Issue.1 , pp. 1-9
    • Brannon-Peppas, L.1
  • 7
    • 0034182386 scopus 로고    scopus 로고
    • Nano and microparticles as controlled drug delivery devices
    • RAVI KUMAR MNV. Nano and microparticles as controlled drug delivery devices. J. Pharm. Pharm. Sci. (2000) 3(2 ):234-258.
    • (2000) J. Pharm. Pharm. Sci. , vol.3 , Issue.2 , pp. 234-258
    • Ravi Kumar, M.N.V.1
  • 8
    • 0035966497 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles as drug delivery devices
    • SOPPIMATH KS, AMINABHAVI TM, KULKARNI AR et al.: Biodegradable polymeric nanoparticles as drug delivery devices. J Control. Release (2001) 70(1-2):1-20.
    • (2001) J. Control. Release , vol.70 , Issue.1-2 , pp. 1-20
    • Soppimath, K.S.1    Aminabhavi, T.M.2    Kulkarni, A.R.3
  • 9
    • 0027432534 scopus 로고
    • Drug-loaded nanoparticles - Preparation methods and drug targeting issues
    • ALLEMAN E, GURNY R, DOELKER E: Drug-loaded nanoparticles - preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. (1993) 39(5):173-191.
    • (1993) Eur. J. Pharm. Biopharm. , vol.39 , Issue.5 , pp. 173-191
    • Alleman, E.1    Gurny, R.2    Doelker, E.3
  • 10
    • 0035821356 scopus 로고    scopus 로고
    • Development and characterization of lipid microparticles as a drug carrier for somatostatin
    • REITHMEIER H, HERRMANN J, GOPFERICH A: Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int. J. Pharm. (2001) 218:133-143.
    • (2001) Int. J. Pharm. , vol.218 , pp. 133-143
    • Reithmeier, H.1    Herrmann, J.2    Gopferich, A.3
  • 12
    • 1942470488 scopus 로고    scopus 로고
    • Cyclodextrins and their uses: A review
    • DEL VALLE EMM: Cyclodextrins and their uses: a review. Process Biochemistry (2004) 39(9):1033-1046.
    • (2004) Process Biochemistry , vol.39 , Issue.9 , pp. 1033-1046
    • Del Valle, E.M.M.1
  • 14
    • 0037018963 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization
    • HU FQ, YUAN H, ZHANG HH et al.: Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int. J. Pharm. (2002) 239:121-128.
    • (2002) Int. J. Pharm. , vol.239 , pp. 121-128
    • Hu, F.Q.1    Yuan, H.2    Zhang, H.H.3
  • 15
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery- A review of the state of art
    • MULLER RH, MADER K, GOHLA S: Solid lipid nanoparticles (SLN) for controlled drug delivery- a review of the state of art. Eur. J. Pharm. Biopharm. (2000) 50:161-177.
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 161-177
    • Muller, R.H.1    Mader, K.2    Gohla, S.3
  • 16
    • 0032982005 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery; drug incorporation and physicochemical characterization
    • SCHWARZ C, MEHNERT W: Solid lipid nanoparticles (SLN) for controlled drug delivery; drug incorporation and physicochemical characterization. J. Microencapsul. (1999) 16(2):205-213.
    • (1999) J. Microencapsul , vol.16 , Issue.2 , pp. 205-213
    • Schwarz, C.1    Mehnert, W.2
  • 17
    • 1542611547 scopus 로고    scopus 로고
    • Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles
    • VENKATESWARLU V, MANJUNATH K: Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J. Control. Release (2004) 95:627-638.
    • (2004) J. Control. Release , vol.95 , pp. 627-638
    • Venkateswarlu, V.1    Manjunath, K.2
  • 18
    • 0031960962 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery- Drug release and release mechanism
    • ZUR MUHLEN A, SCHWARZ C, MEHNERT W: Solid lipid nanoparticles (SLN) for controlled drug delivery- Drug release and release mechanism. Eur. J. Pharm. Biopharm. (1998) 45:149-155.
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 49-155
    • Zur Muhlen, A.1    Schwarz, C.2    Mehnert, W.3
  • 19
    • 0037404980 scopus 로고    scopus 로고
    • The production and characteristics of solid lipid nanoparticles (SLNs)
    • HOU D, XIE C, HUANG K et al: The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials (2003) 24(10):1781-1785.
    • (2003) Biomaterials , vol.24 , Issue.10 , pp. 1781-1785
    • Hou, D.1    Xie, C.2    Huang, K.3
  • 20
    • 0042133226 scopus 로고    scopus 로고
    • Evaluation of polar lipid-hydrophilic polymer microparticles
    • SAVOLAINEN M, HERDER J, KHOO C et al.: Evaluation of polar lipid-hydrophilic polymer microparticles. Int. J. Pharm. (2003) 262(1-2):47-62.
    • (2003) Int. J. Pharm. , vol.262 , Issue.1-2 , pp. 47-62
    • Savolainen, M.1    Herder, J.2    Khoo, C.3
  • 21
    • 0037423789 scopus 로고    scopus 로고
    • Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing
    • PASSERINI N, PERISSUTTI B, ALBERTINI B et al.: Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing. J. Control. Release (2003) 88 2):263-275.
    • (2003) J. Control. Release , vol.88 , Issue.2 , pp. 263-275
    • Passerini, N.1    Perissutti, B.2    Albertini, B.3
  • 22
    • 0027293005 scopus 로고
    • Novel oral controlled-release microspheres using polyglycerol esters of fatty acids
    • AKIYAMA Y, YOSHIOKA M, HORIBE H et al.: Novel oral controlled-release microspheres using polyglycerol esters of fatty acids. J. Control. Release (1993) 26(1):1-10.
    • (1993) J. Control. Release , vol.26 , Issue.1 , pp. 1-10
    • Akiyama, Y.1    Yoshioka, M.2    Horibe, H.3
  • 23
    • 0032996555 scopus 로고    scopus 로고
    • Description and preliminary evaluation of a new ultrasonic atomizer for spray-congealing processes
    • RODRIGUEZ L, PASSERINI N, CAVALLARI C et al.: Description and preliminary evaluation of a new ultrasonic atomizer for spray-congealing processes. Int. J. Pharm. (1999) 183 2):133-143.
    • (1999) Int. J. Pharm. , vol.183 , Issue.2 , pp. 133-143
    • Rodriguez, L.1    Passerini, N.2    Cavallari, C.3
  • 24
    • 0037472095 scopus 로고    scopus 로고
    • Lipid microparticles as sustained release system for a GnRH antagonist (Antide)
    • DEL CURTO MD, CHICCO D, D'ANTONIO M et al.: Lipid microparticles as sustained release system for a GnRH antagonist (Antide). J. Control. Release (2003) 89:297-310.
    • (2003) J. Control. Release , vol.89 , pp. 297-310
    • Del Curto, M.D.1    Chicco, D.2    D'Antonio, M.3
  • 25
    • 12244308490 scopus 로고    scopus 로고
    • Solid lipid microparticle formulations of the pyrethroid gamma-cyhalothrin-incompatibility of the lipid and the pyrethroid and biological properties of the formulations
    • FREDERIKSEN HK, KRISTENSEN HG, PEDERSEN M: Solid lipid microparticle formulations of the pyrethroid gamma-cyhalothrin-incompatibility of the lipid and the pyrethroid and biological properties of the formulations. J. Control. Release (2003) 86:243-252.
    • (2003) J. Control. Release , vol.86 , pp. 243-252
    • Frederiksen, H.K.1    Kristensen, H.G.2    Pedersen, M.3
  • 26
    • 0035072395 scopus 로고    scopus 로고
    • Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- And nanoparticles
    • DEMIREL M, YAZAN Y, MULLER RH et al.: Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles. J. Microencapsul. (2001) 18(3):359-371.
    • (2001) J. Microencapsul , vol.18 , Issue.3 , pp. 359-371
    • Demirel, M.1    Yazan, Y.2    Muller, R.H.3
  • 27
    • 12344294793 scopus 로고    scopus 로고
    • Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration
    • Article 27
    • SANNA V, KIRSCHVINK N, GUSTIN P et al.: Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration. AAPS PharmSci Tech (2004) 5 2):Article 27.
    • (2004) AAPS PharmSci. Tech. , vol.5 , Issue.2
    • Sanna, V.1    Kirschvink, N.2    Gustin, P.3
  • 28
    • 0026074591 scopus 로고
    • Optimization of spray-dried and congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy
    • ELDEM T, SPEISER P, HINCAL A: Optimization of spray-dried and congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy. Pharm. Res. (1991) 8 1):47-54.
    • (1991) Pharm. Res. , vol.8 , Issue.1 , pp. 47-54
    • Eldem, T.1    Speiser, P.2    Hincal, A.3
  • 29
    • 0026552029 scopus 로고
    • Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs
    • BODMEIER R, WANG J, BHAGWATWAR H: Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs. J. Microencapsul. (1992) 9(1):89-98.
    • (1992) J. Microencapsul. , vol.9 , Issue.1 , pp. 89-98
    • Bodmeier, R.1    Wang, J.2    Bhagwatwar, H.3
  • 30
    • 0026527939 scopus 로고
    • Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. II. W/O/W multiple emulsion technique for water-soluble drugs
    • BODMEIER R, WANG J, BHAGWATWAR H: Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. II. W/O/W multiple emulsion technique for water-soluble drugs. J. Microencapsul. (1992) 9(1):99-107.
    • (1992) J. Microencapsul. , vol.9 , Issue.1 , pp. 99-107
    • Bodmeier, R.1    Wang, J.2    Bhagwatwar, H.3
  • 31
    • 0035850227 scopus 로고    scopus 로고
    • Lipid microparticles as parenteral controlled release device for peptides
    • REITHMEIER H, HERRMANN J, GOPFERICH A: Lipid microparticles as parenteral controlled release device for peptides. J. Control. Release (2001) 73:339-350.
    • (2001) J. Control. Release , vol.73 , pp. 339-350
    • Reithmeier, H.1    Herrmann, J.2    Gopferich, A.3
  • 32
    • 0036972245 scopus 로고    scopus 로고
    • Evaluation of cationic sold tipid microparticles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells
    • ERNI C, SUARD C, FREITAS S et al.: Evaluation of cationic sold tipid microparticles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells. Biomaterials (2004) 23:4667-4676.
    • (2004) Biomaterials , vol.23 , pp. 4667-4676
    • Erni, C.1    Suard, C.2    Freitas, S.3
  • 34
    • 0031847390 scopus 로고    scopus 로고
    • Liposphere local anesthetic timed-release for perineural site application
    • MASTERS DB, DOMB AJ: Liposphere local anesthetic timed-release for perineural site application. Pharm. Res. (1998) 15(7):1038-1045.
    • (1998) Pharm. Res. , vol.15 , Issue.7 , pp. 1038-1045
    • Masters, D.B.1    Domb, A.J.2
  • 35
    • 0022498195 scopus 로고
    • 5-Fluorouracil: Carnauba wax microspheres for chemoembloization: An in vitro evaluation
    • BENITA S, ZOUAI O, BENOIT JP: 5-Fluorouracil: carnauba wax microspheres for chemoembloization: An in vitro evaluation. J. Pharm. Sci. US (1986) 75(9):847-851.
    • (1986) J. Pharm. Sci. US , vol.75 , Issue.9 , pp. 847-851
    • Benita, S.1    Zouai, O.2    Benoit, J.P.3
  • 36
    • 0036281847 scopus 로고    scopus 로고
    • Characterization of carbamazepine-Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds
    • PASSERINI N, PERISSUTI B, MONEGHINI M et al.: Characterization of carbamazepine-Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds. J. Pharm. Sci-US (2002) 91(3):699-707.
    • (2002) J. Pharm. Sci.-US , vol.91 , Issue.3 , pp. 699-707
    • Passerini, N.1    Perissuti, B.2    Moneghini, M.3
  • 37
    • 0037837391 scopus 로고    scopus 로고
    • Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate
    • YENER G, INCEGUL T, YENER N: Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate. Int. J. Pharm. (2003) 258:203-207.
    • (2003) Int. J. Pharm. , vol.258 , pp. 203-207
    • Yener, G.1    Incegul, T.2    Yener, N.3
  • 38
    • 0027480638 scopus 로고
    • White beeswax microspheres: A comparative in vitro evaluation of cumulative release of the anticancer agents fluorouracil and ftorafur
    • GIANNOLA LI, DI STEFANO V, DE CARO V: White beeswax microspheres: a comparative in vitro evaluation of cumulative release of the anticancer agents fluorouracil and ftorafur. Pharmazie (1993) 48(2):123-126.
    • (1993) Pharmazie , vol.48 , Issue.2 , pp. 123-126
    • Giannola, L.I.1    Di Stefano, V.2    De Caro, V.3
  • 40
    • 0025777076 scopus 로고
    • Controlled release from glycerol palmito-stearate matrices prepared by dry-heat granulation and compression at elevated temperature
    • MALAMATARIS S, PANAGOPOULOU A, HATZIPANTOU P: Controlled release from glycerol palmito-stearate matrices prepared by dry-heat granulation and compression at elevated temperature. Drug. Dev. Ind. Pharm. (1991) 17:1765-1777.
    • (1991) Drug Dev. Ind. Pharm. , vol.17 , pp. 1765-1777
    • Malamataris, S.1    Panagopoulou, A.2    Hatzipantou, P.3
  • 41
    • 0037026283 scopus 로고    scopus 로고
    • Evaluation of controlled-release polar lipid microparticles
    • SAVOLAINEN M, KHOO C, GLAD H et al.: Evaluation of controlled-release polar lipid microparticles. Int. J. Pharm. (2002) 244:151-161.
    • (2002) Int. J. Pharm. , vol.244 , pp. 151-161
    • Savolainen, M.1    Khoo, C.2    Glad, H.3
  • 42
    • 0036130944 scopus 로고    scopus 로고
    • Production of lipospheres as carriers for bioactive compounds
    • CORTESI R, ESPOSITO E, LUCA G et al.: Production of lipospheres as carriers for bioactive compounds. Biomaterials (2002) 23(11):2283-2294.
    • (2002) Biomaterials , vol.23 , Issue.11 , pp. 2283-2294
    • Cortesi, R.1    Esposito, E.2    Luca, G.3
  • 43
    • 0028954379 scopus 로고
    • Solid lipid nanoparticles (SLN) - An alternative colloidal carrier system for controlled drug delivery
    • MULLER RH, MEHNERT W, LUCKS JS et al.: Solid lipid nanoparticles (SLN) - an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. (1995) 41 1):62-69.
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , Issue.1 , pp. 62-69
    • Muller, R.H.1    Mehnert, W.2    Lucks, J.S.3
  • 44
    • 0034235184 scopus 로고    scopus 로고
    • Preparation of monodispersed solid lipid microspheres using a microchannel emulsification technique
    • SUGIURA S, NAKAJIMA M, TONG J et al.: Preparation of monodispersed solid lipid microspheres using a microchannel emulsification technique. J. Colloid Interf. Sci. (2000) 227 95-103.
    • (2000) J. Colloid Interf. Sci. , vol.227 , pp. 95-103
    • Sugiura, S.1    Nakajima, M.2    Tong, J.3
  • 45
    • 0035885530 scopus 로고    scopus 로고
    • Production of W/O/W emulsions and S/O/W pectin microcapsules by microchannel emulsification
    • KAWAKATSU T, TRAGARDH G, TRAGARDH C: Production of W/O/W emulsions and S/O/W pectin microcapsules by microchannel emulsification. Colloid Surface A (2001) 189:257-264.
    • (2001) Colloid Surface A , vol.189 , pp. 257-264
    • Kawakatsu, T.1    Tragardh, G.2    Tragardh, C.3
  • 46
    • 4243523461 scopus 로고    scopus 로고
    • Spray drying and spray congealing of pharmaceuticals
    • SWARBRICK J, BOYLAN JC (Ed.)
    • KILLEEN MJ: Spray drying and spray congealing of pharmaceuticals. In: Encyclopedia of Pharmaceutical Technology SWARBRICK J, BOYLAN JC (Ed.) (2000):207-221.
    • (2000) Encyclopedia of Pharmaceutical Technology , pp. 207-221
    • Killeen, M.J.1
  • 47
    • 0031597634 scopus 로고    scopus 로고
    • Grain-size analysis by laser diffractometry: Comparison with the sieve-pipette method
    • BEUSELINCK L, GOVERS G, POESEN J et al.: Grain-size analysis by laser diffractometry: comparison with the sieve-pipette method. CATENA (1998) 32(3-4):193-208.
    • (1998) CATENA , vol.32 , Issue.3-4 , pp. 193-208
    • Beuselinck, L.1    Govers, G.2    Poesen, J.3
  • 49
    • 0031259798 scopus 로고    scopus 로고
    • Coincidence correction for electrical-zone (Coulter-counter) particle size analysers
    • WYNN EJW. HOUNSLOW MJ: Coincidence correction for electrical-zone (Coulter-counter) particle size analysers. Powder Technology (1997) 93(2):163-175.
    • (1997) Powder Technology , vol.93 , Issue.2 , pp. 163-175
    • Wynn, E.J.W.1    Hounslow, M.J.2
  • 50
    • 0001155833 scopus 로고    scopus 로고
    • Micromeritics
    • Lippincott Williams & Wilkins, Baltimore
    • MARTIN A. Micromeritics. In: Physical Pharmacy. Lippincott, Williams & Wilkins, Baltimore (2004):423-452.
    • (2004) Physical Pharmacy , pp. 423-452
    • Martin, A.1
  • 55
    • 0021871616 scopus 로고
    • Characterization of drug loading in crospovidone by X-ray photoelectron spectroscopy
    • CARLI F, GARBASSI F: Characterization of drug loading in crospovidone by X-ray photoelectron spectroscopy. J. Pharm. Sci. (1985) 74(9):963-967.
    • (1985) J. Pharm. Sci. , vol.74 , Issue.9 , pp. 963-967
    • Carli, F.1    Garbassi, F.2
  • 56
    • 0034255003 scopus 로고    scopus 로고
    • Preparation in high-shear mixer of sustained-release pellets by melt pelletisation
    • VOINOVICH D, MONEGHINI M, PERISSUTTI B et al.: Preparation in high-shear mixer of sustained-release pellets by melt pelletisation. Int. J. Pharm. (2000) 203(1-2):235-244.
    • (2000) Int. J. Pharm. , vol.203 , Issue.1-2 , pp. 235-244
    • Voinovich, D.1    Moneghini, M.2    Perissutti, B.3
  • 57
    • 0030866983 scopus 로고    scopus 로고
    • Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release
    • WESTESEN K, BUNJES H, KOCH MHJ: Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release. J. Control. Release (1997) 48:223-23.
    • (1997) J. Control. Release , vol.48 , pp. 223-236
    • Westesen, K.1    Bunjes, H.2    Koch, M.H.J.3
  • 58
    • 0027264830 scopus 로고
    • Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction
    • WESTESEN K, SIEKMANN B, KOCH MHJ: Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction. Int. J. Pharm. (1993) 93(1-3):189-199.
    • (1993) Int. J. Pharm. , vol.93 , Issue.1-3 , pp. 189-199
    • Westesen, K.1    Siekmann, B.2    Koch, M.H.J.3
  • 59
    • 0025732814 scopus 로고
    • Polymorphic behavior of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy
    • ELDEM T, SPEISER P, ALTORFER H: Polymorphic behavior of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy. Pharm. Res. (1991) 8(2):178-184.
    • (1991) Pharm. Res. , vol.8 , Issue.2 , pp. 178-184
    • Eldem, T.1    Speiser, P.2    Altorfer, H.3
  • 61
    • 0001155833 scopus 로고    scopus 로고
    • Micromeritics
    • Lippincott, Williams & Wilkins, Baltimore
    • MARTIN A: Micromeritics. In: Physical Pharmacy. Lippincott, Williams & Wilkins, Baltimore (2004):30-36.
    • (2004) Physical Pharmacy , pp. 30-36
    • Martin, A.1
  • 62
    • 0000754268 scopus 로고    scopus 로고
    • The evolution of hot-stage microscopy to aid solid-state characterizations of pharmaceutical solids
    • VITEZ IM, NEWMAN AW, DAVIDOVICH M et al.: The evolution of hot-stage microscopy to aid solid-state characterizations of pharmaceutical solids. Thermochimica Acta (1998) 324(1-2): 187-196.
    • (1998) Thermochimica Acta , vol.324 , Issue.1-2 , pp. 187-196
    • Vitez, I.M.1    Newman, A.W.2    Davidovich, M.3
  • 63
    • 0033514520 scopus 로고    scopus 로고
    • Polymorphic transformations during crystallization processes of fatty acids studied with FT-IR spectroscopy
    • KANEKO F, TASHIRO K, KOBAYASHI M: Polymorphic transformations during crystallization processes of fatty acids studied with FT-IR spectroscopy. J. Cryst. Growth (1999) 198-199 (Part 2): 1352-1359.
    • (1999) J. Cryst. Growth , vol.198-199 , Issue.PART 2 , pp. 1352-1359
    • Kaneko, F.1    Tashiro, K.2    Kobayashi, M.3
  • 64
    • 12344305559 scopus 로고    scopus 로고
    • Solid lipid microparticle versus inclusion complex of piribedil
    • Proceedings of the European Conference on Drug Delivery and Pharmaceutical Technology. 10-12 May, 2004. Seville, Spain
    • YAZAN Y, DEMIREL M, BUYUKKOROGLU B et al.: Solid lipid microparticle versus inclusion complex of piribedil. Proceedings of the European Conference on Drug Delivery and Pharmaceutical Technology 10-12 May, 2004. Seville, Spain (2004).
    • (2004)
    • Yazan, Y.1    Demirel, M.2    Buyukkoroglu, B.3
  • 65
    • 12344272112 scopus 로고    scopus 로고
    • Solid lipid microparticles for administration by inhalation: Optimisation of manufacturing parameters
    • Proceedings of the European Conference on Drug Delivery and Pharmaceutical Technology. 10-12 May, Seville, Spain
    • JASPART S, BODSON C, BERTHOLET P et al.: Solid lipid microparticles for administration by inhalation: optimisation of manufacturing parameters. Proceedings of the European Conference on Drug Delivery and Pharmaceutical Technology. 10-12 May, Seville, Spain (2004).
    • (2004)
    • Jaspart, S.1    Bodson, C.2    Bertholet, P.3
  • 66
    • 12344272112 scopus 로고    scopus 로고
    • Solid lipid microparticles for administration by inhalation: Optimisation of manufacturing parameters and preliminary tolerance study
    • Proceedings 12th Forum of Pharmaceutical Sciences. 6-7 May, Blankenberge, Belgium
    • JASPART S, KIRSCHVINK N, CHIAP P et al.: Solid lipid microparticles for administration by inhalation: optimisation of manufacturing parameters and preliminary tolerance study. Proceedings 12th Forum of Pharmaceutical Sciences. 6-7 May, Blankenberge, Belgium (2004).
    • (2004)
    • Jaspart, S.1    Kirschvink, N.2    Chiap, P.3
  • 67
    • 2542509770 scopus 로고    scopus 로고
    • Importance of the test medium for the release kinetics of a somatostatin analogue from poly(-lactide-co-glycolide) microspheres
    • BLANCO-PRIETO MJ, BESSEGHIR K, ORSOLINI P et al.: Importance of the test medium for the release kinetics of a somatostatin analogue from poly(-lactide-co-glycolide) microspheres. Int. J. Pharm. (1999) 184(2):243-250.
    • (1999) Int. J. Pharm. , vol.84 , Issue.2 , pp. 243-250
    • Blanco-Prieto, M.J.1    Besseghir, K.2    Orsolini, P.3
  • 68
    • 0035839191 scopus 로고    scopus 로고
    • Preparation, characterization and in vivo evaluation of 120-day poly(-lactide) leuprolide microspheres
    • WOO BH, KOSTANSKI JW, GEBREKIDAN S et al.: Preparation, characterization and in vivo evaluation of 120-day poly(-lactide) leuprolide microspheres. J. Control. Release (2001) 75 3):307-315.
    • (2001) J. Control. Release , vol.75 , Issue.3 , pp. 307-315
    • Woo, B.H.1    Kostanski, J.W.2    Gebrekidan, S.3
  • 69
    • 0345148806 scopus 로고    scopus 로고
    • Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures
    • OLBRICH C, MULLER RH: Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures. Int. J. Pharm. (1999) 180 1):31-39.
    • (1999) Int. J. Pharm. , vol.180 , Issue.1 , pp. 31-39
    • Olbrich, C.1    Muller, R.H.2
  • 70
    • 0037177514 scopus 로고    scopus 로고
    • Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)-effect of surfactants, storage time and crystallinity
    • OLBRICH C, KAYSER O, MULLER RH: Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)-effect of surfactants, storage time and crystallinity. Int. J. Pharm. (2002) 237 1-2):119-128.
    • (2002) Int. J. Pharm. , vol.237 , Issue.1-2 , pp. 119-128
    • Olbrich, C.1    Kayser, O.2    Muller, R.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.