The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver

Journal of Biological Chemistry

Volumn 285, Issue 2, 2010, Pages 1113-1121

  Trottier, Jocelyn ^a   El Husseini, Diala ^a   Perreault, Martin ^a   Pâquet, Sophie ^a   Caron, Patrick ^a   Bourassa, Sylvie ^b   Verreault, Mélanie ^a   Inaba, Ted T ^c   Poirier, Guy G ^b   Bélanger, Alain ^d   Guillemette, Chantal ^a   Trauner, Michael ^e   Barbier, Olivier ^a  

^a Université Laval   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOZYMES; ANIMAL MODEL; CODING REGION; CORRELATION STUDIES; GLUCURONIDATION; GLUCURONIDES; HEK293 CELLS; HUMAN LIVER; HUMAN TISSUES; IN-VITRO; INTERMEDIATE CAPACITY; LITHOCHOLIC ACIDS; PHARMACOKINETIC PROPERTIES; SINGLE NUCLEOTIDE POLYMORPHISMS;

ACIDS; ESTERIFICATION; ESTERS; LIVER; POLYMORPHISM; SULFUR COMPOUNDS;

ENZYMES;

ALLOENZYME; GLUCURONIDE; GLUCURONOSYLTRANSFERASE 1A3; LITHOCHOLIC ACID; MESSENGER RNA; NORURSODEOXYCHOLIC ACID DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID DERIVATIVE;

ARTICLE; CATALYSIS; CELL STRAIN HEK293; CHOLESTASIS; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; GENETIC VARIABILITY; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTESTINE; LIQUID CHROMATOGRAPHY; LIVER; LIVER CELL; MASS SPECTROMETRY; MICROSOME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING;

ANIMALS; CELL LINE; CHOLANGITIS, SCLEROSING; CHOLIC ACIDS; DISEASE MODELS, ANIMAL; ESTERS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; MICROSOMES, LIVER; NORSTEROIDS; POLYMORPHISM, GENETIC; RIFAMPIN;

ANIMALIA;

EID: 74049083754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.073908     Document Type: Article

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