Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFβ3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB signaling cascade

Brain Research

Volumn 1305, Issue , 2009, Pages 1-13

  Maeda, Shyuichi ^a   Nakajima, Kazuyuki ^a,b   Tohyama, Yoko ^a   Kohsaka, Shinichi ^b  

^a SOKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Akt; Astrocytes; Phosphatidylinositol 3 kinase; Plasmin(ogen); Proteinase activated receptor 1; Transforming growth factor 3

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; FIBRINOLYTIC AGENT; FIBROBLAST GROWTH FACTOR; FLAVONOID; MESSENGER RNA; MORPHOLINE DERIVATIVE; N3 CYCLOPROPYL 7 ((4 (1 METHYLETHYL)PHENYL)METHYL) 7H PYRROLO(3, 2 F)QUINAZOLINE 1,3 DIAMINE; N3-CYCLOPROPYL-7-((4-(1-METHYLETHYL)PHENYL)METHYL)-7H-PYRROLO(3, 2-F)QUINAZOLINE-1,3-DIAMINE; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMIN; PLASMINOGEN; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR 1; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA3;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; ASTROCYTE; CELL CULTURE; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROGLIA; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELLS, CULTURED; CHROMONES; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FIBRINOLYSIN; FIBRINOLYTIC AGENTS; FIBROBLAST GROWTH FACTORS; FLAVONOIDS; IMMUNOHISTOCHEMISTRY; MICROGLIA; MORPHOLINES; NERVE GROWTH FACTORS; NEURONS; PHOSPHORYLATION; PLASMINOGEN; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; QUINAZOLINES; RATS; RECEPTOR, PAR-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA3;

EID: 73949131535     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.09.025     Document Type: Article

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