Epitopes recognized by a nonautoreactive murine anti-N-propionyl meningococcal group B polysaccharide monoclonal antibody

Infection and Immunity

Volumn 73, Issue 4, 2005, Pages 2123-2128

  Moe, Gregory R ^a,b   Dave, Apurva ^a,c   Granoff, Dan M ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b University of Chicago ^*  (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; MENINGOCOCCUS VACCINE; MONOCLONAL ANTIBODY; N PROPIONYL MENIGOCOCCAL GROUP B POLYSACCARIDE MONOCLONAL ANTIBODY; POLYSACCHARIDE; POLYSIALIC ACID; TETANUS TOXOID; UNCLASSIFIED DRUG; BACTERIAL POLYSACCHARIDE; BACTERIUM ANTIBODY; MENINGOCOCCAL GROUP B POLYSACCHARIDE; VACCINE;

ANTIBODY AFFINITY; ANTIGEN RECOGNITION; ARTICLE; BACTERICIDAL ACTIVITY; DRUG ACETYLATION; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGENICITY; IMMUNOREACTIVITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; ANIMAL; EPITOPE MAPPING; IMMUNOLOGY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; EPITOPE MAPPING; MAGNETIC RESONANCE SPECTROSCOPY; MENINGOCOCCAL VACCINES; MICE; NEISSERIA MENINGITIDIS; POLYSACCHARIDES, BACTERIAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VACCINES, CONJUGATE;

EID: 16244395446     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.4.2123-2128.2005     Document Type: Article

References (43)

1. Ashton, F. E., J. A. Ryan, F. Michon, and H. J. Jennings. 1989. Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide. Microb. Pathog. 6:455-458.
2. Azmi, F. H., A. H. Lucas, H. V. Raff, and D. M. Granoff. 1994. Variable region sequences and idiotypic expression of a protective human immunoglobulin M antibody to capsular polysaccharides of Neisseria meningitidis group B and Escherichia coli K1. Infect. Immun. 62:1776-1786.
3. Bhattacharjee, A. K., H. J. Jennings, C. P. Kenny, A. Martin, and I. C. Smith. 1975. Structural determination of the sialic acid polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance. J. Biol. Chem. 250:1926-1932.
4. Brisson, J. R., H. Baumann, A. Imberty, S. Perez, and H. J. Jennings. 1992. Helical epitope of the group B meningococcal alpha(2-8)-linked sialic acid polysaccharide. Biochemistry 31:4996-5004.
5. Bruge, J., N. Bouveret-Le Cam, B. Danve, G. Rougon, and D. Schulz. 2004. Clinical evaluation of a group B meningococcal N-propionylated polysaccharide conjugate vaccine in adult, male volunteers. Vaccine 22:1087-1096.
6. Costantino, P., F. Norelli, A. Giannozzi, S. D'Ascenzi, A. Bartoloni, S. Kaur, D. Tang, R. Seid, S. Viti, R. Paffetti, M. Bigio, C. Pennatini, G. Averani, V. Guarnieri, E. Gallo, N. Ravenscroft, C. Lazzeroni, R. Rappuoli, and C. Ceccarini. 1999, Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines. Vaccine 17:1251-1263.
7. Evans, S. V., B. W. Sigurskjold, H. J. Jennings, J. R. Brisson, R. To, W. C. Tse, E. Altman, M. Frosch, C. Weisgerber, H. D. Kratzin, et al. 1995. Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2→8)-polysialic acid. Biochemistry 34:6737-6744.
8. Finne, J., M. Leinonen, and P. H. Makela. 1983. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis. Lancet 2:355-357.
9. Frosch, M., I. Gorgen, G. J. Boulnois, K. N. Timmis, and D. Bitter-Suermann. 1985. NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci. Proc. Natl. Acad. Sci. USA 82:1194-1198.
10. Fusco, P. C., F. Michon, J. Y. Tai, and M. S. Blake. 1997. Preclinical evaluation of a novel group B meningococcal conjugate vaccine that elicits bactericidal activity in both mice and nonhuman primates. J. Infect. Dis. 175:364-372.
11. Goldschneider, I., E. C. Gotschlich, and M. S. Artenstein. 1969. Human immunity to the meningococcus. II. Development of natural immunity. J. Exp. Med. 129:1327-1348.
12. Granoff, D. M., A. Bartoloni, S. Ricci, E. Gallo, D. Rosa, N. Ravenscroft, V. Guarnieri, R. C. Seid, A. Shan, W. R. Usinger, S. Tan, Y. E. McHugh, and G. R. Moe. 1998. Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid. J. Immunol. 160:5028-5036.
13. Guo, Z., and H. Jennings. 2001. N-Propionylation, p. 55-60. In A. J. Pollard and C. J. M. Maiden (ed.), Meningococcal vaccines: methods and protocols. Humana Press. Inc., Tolowa, N.J.
14. Habeeb, A. F. 1966. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal. Biochem. 14:328-336.
15. Henderson, T. J., R. M. Venable, and W. Egan. 2003. Conformational flexibility of the group B meningococcal polysaccharide in solution. J. Am. Chem. Soc. 125:2930-2939.
16. Hurpin, C. M., E. D. Carosella, and P. A. Cazenave. 1992. Bactericidal activity of two IgG2a murine monoclonal antibodies with distinct fine specificities for group B Neisseria meningitidis capsular polysaccharide. Hybridoma 11:677-687.
17. Jennings, H. J., A. Gamian, and F. E. Ashton. 1987. N-Propionylated group B meningococcal polysaccharide mimics a unique epitope on group B Neisseria meningitidis. J. Exp. Med. 165:1207-1211.
18. Jennings, H. J., and C. Lugowski. 1981. Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates. J. Immunol. 127:1011-1018.
19. Jennings, H. J., R. Roy, and A. Gamian. 1986. Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine. J. Immunol. 137:1708-1713.
20. Jennings, H. J., R. Roy, and F. Michon. 1985. Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis. J. Immunol. 134:2651-2657.
21. Jodar, L., I. Feavers, D. Salisbury, and D. M. Granoff. 2002. Development of vaccines against meningococcal disease. Lancet 359:1499-1508.
22. Livingston, B. D., J. L. Jacobs, M. C. Glick, and F. A. Troy. 1988. Extended polysialic acid chains (n > 55) in glycoproteins from human neuroblastoma cells. J. Biol. Chem. 263:9443-9448.
23. MacKenzie, C. R., and H. J. Jennings. 2003. Characterization of polysaccharide conformational epitopes by surface plasmon resonance. Methods Enzymol. 363:340-354.
24. Mandrell, R. E., F. H. Azmi, and D. M. Granoff. 1995. Complement-mediated bactericidal activity of human antibodies to poly alpha 2→8 N-acetylneuraminic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B. J. Infect Dis. 172:1279-1289.
25. Mandrell, R. E., and W. D. Zollinger. 1982. Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants. J. Immunol. 129:2172-2178.
26. Michon, F., J. R. Brisson, and H. J. Jennings. 1987. Conformational differences between linear alpha (2-8)-linked homosialooligosaccharides and the epitope of the group B meningococcal polysaccharide. Biochemistry 26:8399-8405.
27. Mitsuoka, C., K. Ohmori, N. Kimura, A. Kanamori, S. Komba, H. Ishida, M. Kiso, and R. Kannagi. 1999. Regulation of selectin binding activity by cyclization of sialic acid moiety of carbohydrate ligands on human leukocytes. Proc. Natl. Acad. Sci. USA 96:1597-1602.
28. Moe, G. R., S. Tan, and D. M. Granoff. 1999. Differences in surface expression of NspA among Neisseria meningitidis group B strains. Infect. Immun. 67:5664-5675.
29. Moe, G. R., P. Zuno-Mitchell, S. S. Lee, A. H. Lucas, and D. M. Granoff. 2001. Functional activity of anti-neisserial surface protein A monoclonal antibodies against strains of Neisseria meningitidis serogroup B. Infect. Immun. 69:3762-3771.
30. Moreno, C., J. Hewitt, K. Hastings, and D. Brown. 1983. Immunological properties of monoclonal antibodies specific for meningococcal polysaccharides: the protective capacity of IgM antibodies specific for polysaccharide group B. J. Gen. Microbiol. 129:2451-2456.
31. Morley, S. L., and A. J. Pollard. 2001. Vaccine prevention of meningococcal disease, coming soon? Vaccine 20:666-687.
32. Orskov, F., I. Orskov, A. Sutton, R. Schneerson, W. Lin, W. Egan, G. E. Hoff, and J. B. Robbins. 1979. Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide. J. Exp. Med. 149:669-685.
33. Pon, R. A., M. Lussier, Q. L. Yang, and H. J. Jennings. 1997. N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis. J. Exp. Med. 185:1929-1938.
34. Poolman, J. T., P. A. Van Der Ley, and J. Tommassen. 1995. Surface structures and secreted products of meningococci, p. 21-34. In K. Cartwright (ed.), Meningococcal disease. John Wiley & Sons, New York, N.Y.
35. Raff, H. V., C. Bradley, W. Brady, K. Donaldson, L. Lipsich, G. Maloney, W. Shuford, M. Walls, P. Ward, E. Wolff, et al. 1991. Comparison of functional activities between IgG1 and IgM class-switched human monoclonal antibodies reactive with group B streptococci or Escherichia coli K1. J. Infect Dis. 163:346-354.
36. Rohr, T. E., and F. A. Troy. 1980. Structure and biosynthesis of surface polymers containing polysialic acid in Escherichia coli. J. Biol. Chem. 255:2332-2342.
37. Rosenstein, N. E., B. A. Perkins, D. S. Stephens, T. Popovic, and J. M. Hughes. 2001. Meningococcal disease. N, Engl. J. Med. 344:1378-1388.
38. Seid, R. 2003. Neisseria meningitidis serogroup B glycoconjugates. U.S. patent 6,638,513.
39. Shin, J. S., J. S. Lin, P. W. Anderson, R. A. Insel, and M. H. Nahm. 2001. Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes. Infect. Immun. 69:3335-3342.
40. Svennerholm, L. 1957. Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim. Biophys. Acta 24:604-611.
41. Troy, F. A. 1973. Chemistry and biosynthesis of the poly(γ-D- glutamyl) capsule in Bacillus licheniformis. II. Characterization and structural properties of the enzymatically synthesized polymer. J. Biol. Chem. 248:316-324.
42. Udenfriend, S., S. Stein, P. Bohlen, W. Dairman, W. Leimgruber, and M. Weigele. 1972. Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range. Science 178:871-872.
43. Welsch, J. A., G. R. Moe, R. Rossi, J. Adu-Bobie, R. Rappuoli, and D. M. Granoff. 2003. Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. J. Infect. Dis. 188:1730-1740.