Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies

Molecular Immunology

Volumn 43, Issue 9, 2006, Pages 1424-1431

  Moe, Gregory R ^a   Dave, Apurva ^a,b   Granoff, Dan M ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Autoantibodies; Autoantigens; Meningococcal vaccine; Structural models; V region genes

Indexed keywords

MONOCLONAL ANTIBODY; POLYSACCHARIDE;

ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC ANALYSIS; MOLECULAR CLONING; MOLECULAR GENETICS; MOLECULAR RECOGNITION; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; AUTOANTIBODIES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MENINGOCOCCAL VACCINES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEISSERIA MENINGITIDIS, SEROGROUP B; POLYSACCHARIDES, BACTERIAL; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SIALIC ACIDS;

MURINAE; NEISSERIA MENINGITIDIS; NEISSERIA MENINGITIDIS SEROGROUP B;

EID: 33644822906     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.07.033     Document Type: Article

References (40)

1. S.F. Altschul, T.L. Madden, A.A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D.J. Lipman Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucl. Acids Res. 25 1997 3389 3402
2. F.E. Ashton, J.A. Ryan, F. Michon, and H.J. Jennings Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide Microb. Pathog. 6 1989 455 458
3. F.H. Azmi, A.H. Lucas, H.V. Raff, and D.M. Granoff Variable region sequences and idiotypic expression of a protective human immunoglobulin M antibody to capsular polysaccharides of Neisseria meningitidis group B and Escherichia coli K1 Infect. Immun. 62 1994 1776 1786
4. N.A. Baker, D. Sept, S. Joseph, M.J. Hoist, and J.A. McCammon Electrostatics of nanosystems: application to microtubules and the ribosome Proc. Natl. Acad. Sci. U.S.A. 98 2001 10037 10041
5. J.D. Berry, D.J. Boese, D.K. Law, W.D. Zollinger, and R.S. Tsang Molecular analysis of monoclonal antibodies to group variant capsular polysaccharide of Neisseria meningitidis: recurrent heavy chains and alternative light chain partners Mol. Immunol. 42 2005 335 344
6. R. Chenna, H. Sugawara, T. Koike, R. Lopez, T.J. Gibson, D.G. Higgins, and J.D. Thompson Multiple sequence alignment with the Clustal series of programs Nucl. Acids Res. 31 2003 3497 3500
7. D. Eilat, D.M. Webster, and A.R. Rees V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice J. Immunol. 141 1988 1745 1753
8. S.V. Evans, B.W. Sigurskjold, H.J. Jennings, J.R. Brisson, R. To, W.C. Tse, E. Altman, M. Frosch, C. Weisgerber, and H.D. Kratzin Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2 → 8)-polysialic acid Biochemistry 34 1995 6737 6744
9. J. Finne, M. Leinonen, and P.H. Makela Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis Lancet 2 1983 355 357
10. M. Frosch, I. Gorgen, G.J. Boulnois, K.N. Timmis, and D. Bitter-Suermann NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci Proc. Natl. Acad. Sci. U.S.A. 82 1985 1194 1198
11. P.C. Fusco, F. Michon, J.Y. Tai, and M.S. Blake Preclinical evaluation of a novel group B meningococcal conjugate vaccine that elicits bactericidal activity in both mice and nonhuman primates J. Infect. Dis. 175 1997 364 372
12. G.S. Gilkeson, D.D. Bloom, D.S. Pisetsky, and S.H. Clarke Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines J. Immunol. 151 1993 1353 1364
13. D.M. Granoff, A. Bartoloni, S. Ricci, E. Gallo, D. Rosa, N. Ravenscroft, V. Guarnieri, R.C. Seid, A. Shan, W.R. Usinger, S. Tan, Y.E. McHugh, and G.R. Moe Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid J. Immunol. 160 1998 5028 5036
14. D.M. Granoff, I.M. Feavers, and R. Borrow Meningococcal vaccines S.A.O. Plotkin A. Walter Vaccines 2004 Saunders Philadelphia, PA 959 988
15. H.J. Jennings, A. Gamian, and F.E. Ashton N-propionylated group B meningococcal polysaccharide mimics a unique epitope on group B Neisseria meningitidis J. Exp. Med. 165 1987 1207 1211
16. H.J. Jennings, and C. Lugowski Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates J. Immunol. 127 1981 1011 1018
17. H.J. Jennings, R. Roy, and A. Gamian Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine J. Immunol. 137 1986 1708 1713
18. H.J. Jennings, R. Roy, and F. Michon Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis J. Immunol. 134 1985 2651 2657
19. L. Jodar, I. Feavers, D. Salisbury, and D.M. Granoff Development of vaccines against meningococcal disease Lancet 359 2002 1499 1508
20. S. Klebert, H.D. Kratzin, B. Zimmermann, M. Vaesen, M. Frosch, C. Weisgerber, D. Bitter-Suermann, and N. Hilschmann Primary structure of the murine monoclonal IgG2a antibody mAb735 against alpha (2-8) polysialic acid. 2. Amino acid sequence of the heavy (H-) chain Fd' region Biol. Chem. Hoppe Seyler 374 1993 993 1000
21. M.R. Krishnan, N.T. Jou, and T.N. Marion Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies J. Immunol. 157 1996 2430 2439
22. M.R. Krishnan, and T.N. Marion Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice Scand. J. Immunol. 48 1998 223 232
23. B.D. Livingston, J.L. Jacobs, M.C. Glick, and F.A. Troy Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells J. Biol. Chem. 263 1988 9443 9448
24. R.E. Mandrell, F.H. Azmi, and D.M. Granoff Complement-mediated bactericidal activity of human antibodies to poly alpha 2 → 8 N-acetylneuraminic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B J. Infect. Dis. 172 1995 1279 1289
25. R.E. Mandrell, and W.D. Zollinger Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants J. Immunol. 129 1982 2172 2178
26. A.C. Martin, J.C. Cheetham, and A.R. Rees Molecular modeling of antibody combining sites Meth. Enzymol. 203 1991 121 153
27. R.C. Mellors Autoimmune disease in NZB/BL mice. 3. Induction of membranous glomerulonephritis in young mice by the transplantation of spleen cells from old mice J. Exp. Med. 123 1966 1025 1034
28. G.R. Moe, A. Dave, and D.M. Granoff Epitopes recognized by a nonautoreactive murine anti-N-propionyl meningococcal group B polysaccharide monoclonal antibody Infect. Immun. 73 2005 2123 2128
29. C. Moreno, J. Hewitt, K. Hastings, and D. Brown Immunological properties of monoclonal antibodies specific for meningococcal polysaccharides: the protective capacity of IgM antibodies specific for polysaccharide group B J. Gen. Microbiol. 129 Pt 8 1983 2451 2456
30. S.L. Morley, and A.J. Pollard Vaccine prevention of meningococcal disease, coming soon? Vaccine 20 2001 666 687
31. K.C. O'Connor, K. Nguyen, and B.D. Stollar Recognition of DNA by VH and Fv domains of an IgG anti-poly(dC) antibody with a singly mutated VH domain J. Mol. Recognit. 14 2001 18 28
32. R.A. Pon, M. Lussier, Q.L. Yang, and H.J. Jennings N-propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitides J. Exp. Med. 185 1997 1929 1938
33. H.V. Raff, C. Bradley, W. Brady, K. Donaldson, L. Lipsich, G. Maloney, W. Shuford, M. Walls, P. Ward, and E. Wolff Comparison of functional activities between IgG1 and IgM class-switched human monoclonal antibodies reactive with group B streptococci or Escherichia coli K1 J. Infect. Dis. 163 1991 346 354
34. N.E. Rosenstein, B.A. Perkins, D.S. Stephens, T. Popovic, and J.M. Hughes Meningococcal disease N. Engl. J. Med. 344 2001 1378 1388
35. J.S. Shin, J.S. Lin, P.W. Anderson, R.A. Insel, and M.H. Nahm Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes Infect. Immunol. 69 2001 3335 3342
36. M. Shlomchik, M. Mascelli, H. Shan, M.Z. Radic, D. Pisetsky, A. Marshak-Rothstein, and M. Weigert Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation J. Exp. Med. 171 1990 265 292
37. D.M. Tillman, N.T. Jou, R.J. Hill, and T.N. Marion Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB × NZW)F1 mice J. Exp. Med. 176 1992 761 779
38. M. Vaesen, M. Frosch, C. Weisgerber, K. Eckart, H. Kratzin, D. Bitter-Suermann, and N. Hilschmann Primary structure of the murine monoclonal IgG2a antibody mAb735 against alpha (2-8) polysialic acid. 1) Amino-acid sequence of the light (L-) chain, kappa-isotype Biol. Chem. Hoppe Seyler 372 1991 451 453
39. Z. Wang, M. Raifu, M. Howard, L. Smith, D. Hansen, R. Goldsby, and D. Ratner Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3′-5′ exonuclease activity J. Immunol. Meth. 233 2000 167 177
40. W.D. Zollinger, R.E. Mandrell, J.M. Griffiss, P. Altieri, and S. Berman Complex of meningococcal group B polysaccharide and type 2 outer membrane protein immunogenic in man J. Clin. Invest. 63 1979 836 848