Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer

Carcinogenesis

Volumn 30, Issue 12, 2009, Pages 2023-2030

  Pulling, Leah C ^b   Grimes, Marcie J ^a   Damiani, Leah A ^a   Juri, Daniel E ^a   Do, Kieu ^a   Tellez, Carmen S ^a   Belinsky, Steven A ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b Central New Mexico Community College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DEATH ASSOCIATED PROTEIN KINASE; APOPTOSIS REGULATORY PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; DEATH-ASSOCIATED PROTEIN KINASE; MESSENGER RNA;

ARTICLE; BINDING SITE; BREAST CANCER; CONTROLLED STUDY; CPG ISLAND; EXON; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION SITE; APOPTOSIS; DNA METHYLATION; GENE DELETION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BINDING SITES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 73949098054     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp276     Document Type: Article

References (35)

1. Lehmann, U. et al. (2009) Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. Clin. Cancer Res., 11, 3654-3660.
2. Katzenellenbogen, R.A. et al. (1999) Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood, 93, 4347-4353.
3. Tang, X. et al. (2000) Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small cell lung cancer. J. Natl Cancer Inst., 92, 1511-1516.
4. Kim, D.H. et al. (2001) Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer. Oncogene, 20, 1765-1770.
5. Belinsky, S.A. et al. (2007) Predicting gene promoter methylation in lung tumors by evaluating sputum and serum. Br. J. Cancer, 96, 1278-1283.
6. Lehmann, U. et al. (2002) Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype. Cancer Res., 62, 6634-6638.
7. Dulaimi, E. et al. (2004) Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin. Cancer Res., 10, 6189-6193.
8. Belinsky, S.A. et al. (2002) Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res., 62, 2370-2377.
9. Deiss, L.P. et al. (1995) Identification of a novel serine-threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferoninduced cell death. Genes Dev., 9, 15-30.
10. Inbal, B. et al. (2000) Death associated protein kinase-related protein 1, a novel serine-threonine kinase involved in apoptosis. Mol. Cell. Biol., 20, 1044-1054.
11. Cohen, O. et al. (1999) DAP-kinase participates in TNF-a- and Fas-induced apoptosis and its function requires the death domain. J. Cell Biol., 146, 141-148.
12. Pelled, D. et al. (2002) Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J. Biol. Chem., 277, 1957-1961.
13. Jang, C.W. et al. (2002) TGF-b induces apoptosis through Smad-mediated expression of DAP-kinase. Nat. Cell Biol., 4, 51-58.
14. Cohen, O. et al. (2001) DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer. Cell Death Diff., 8, 6-15.
15. Raveh, T. et al. (2001) DAP-Kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat. Cell Biol., 3, 1-7.
16. Inbal, B. et al. (1997) DAP-kinase links the control of apoptosis to metastasis. Nature, 390, 180-184.
17. Gonzalez-Gomez, P. et al. (2003) Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors. Oncol. Rep., 10, 1031-1033.
18. Lévy, D. et al. (2004) Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis. Clin. Cancer Res., 10, 3124-3130.
19. Livingston, R.J. et al. (2004) Homo sapiens Death-associated Protein Kinase 1 (DAPK1) Gene, Complete cds. Department of Genome Sciences, Seattle, WA NIEHS ES15478.
20. Toyooka, S. et al. (2003) Epigenetic down-regulation of death-association protein kinase in lung cancers. Clin. Cancer Res., 9, 3034-3041.
21. Quandt, K. et al. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res., 23, 4878-4884.
22. Takai, D. et al. (2002) Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc. Natl Acad. Sci. USA, 99, 3740-3745.
23. Giacopelli, F. et al. (2003) The first intron of the human osteopontin gene contains a C/EBP-beta-responsive enhancer. Gene Expr., 11, 95-104.
24. Charron, M. et al. (2007) The cathepsin L first intron stimulates gene expression in rat sertoli cells. Biol. Reprod., 76, 813-824.
25. Kolb, A. (2003) The first intron of the murine beta-casein gene contains a functional promoter. Biochem. Biophys. Res. Commun., 306, 1099-1105.
26. Homma, N. et al. (2006) Spreading of methylation within RUNX3 CpG island in gastric cancer. Cancer Sci., 97, 51-56.
27. Guerardel, C. et al. (2001) Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. J. Biol. Chem., 276, 3078-3089.
28. Chen, W.Y. et al. (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat. Genet., 33, 197-202.
29. Volker, J.L. et al. (1997) Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNAbinding activity. Genes Dev., 11, 1435-1446.
30. Shirra, M.K. et al. (1998) LSR and NTF-1 share a conserved DNA recognition motif yet require different oligomerization states to form a stable protein-DNA complex. J. Biol. Chem., 273, 19260-19268.
31. Friedman, J.R. et al. (2006) The Foxa family of transcription factors in development and metabolism. Cell. Mol. Life Sci., 63, 2317-2328.
32. van der Sluis, M. et al. (2008) Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochem. Biophys. Res. Commun., 369, 1108-1113.
33. Nakayama, A. et al. (2001) Characterization of two promoters that regulate alternative transcripts in the microtubule-associated protein (MAP) 1A gene. Biochim. Biophys. Acta, 1518, 260-266.
34. Lorincz, M.C. et al. (2004) Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells. Nat. Struct. Mol. Biol., 11, 1068-1075.
35. Belinsky, S.A. et al. (2006) Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high- risk cohort. Cancer Res., 66, 3338-3344.