Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity

Genes and Development

Volumn 11, Issue 11, 1997, Pages 1435-1446

  Volker, Janet L ^a   Rameh, Lucia E ^a   Zhu, Quan ^a,b   DeCaprio, James ^a   Hansen, Ulla ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b IntraImmune Therapies Inc   (United States)

Author keywords

DNA binding; LSF; MAP kinase; Mitogens; Phosphorylation; T lymphocytes

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MITOGENESIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION;

MAMMALIA;

EID: 0030911590     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.11.1435     Document Type: Article

References (65)

1. Abdel-Hafiz, H.A.-M., L.E. Heasley, J.M. Kyriakis, J. Avruch, D.J. Kroll, G.L. Johnson, and J.P. Hoeffler. 1992. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol. Endocrinol. 6: 2079-2089.
2. Abrahamsen, M.S. and D.R. Morris. 1990. Cell type-specific mechanisms of regulating expression of the ornithine decarboxylase gene after growth stimulation. Mol. Cell. Biol. 10: 5525-5528.
3. Andrews, N.C. and D.V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19: 2499.
4. Boulton, T.G., Z. Zhong, Z. Wen, J.E. Darnell Jr., N. Stahl, and G.D. Yancopoulos. 1995. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. 92: 6915-6919.
5. Boyle, W.J., P. Van Der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation of thin-layer cellulose plates. Methods Enzymol. 201: 110-149.
6. Chellappan, S.P., S. Hiebert, M. Mudryj, J.M. Horowitz, and J.R. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65: 1053-1061.
7. Chen, R.-H., C. Sarnecki, and J. Blenis. 1992. Nuclear localization and regulation of erk-and rsk-encoded protein kinases. Mol. Cell. Biol. 12: 915-927.
8. Chen, R.-H., C. Abate, and J. Blenis. 1993. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc. Natl. Acad. Sci. 90: 10952-10956.
9. rsk in vitro. Mol. Cell. Biol. 11: 1868-1874.
10. Crabtree, G.R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science 243: 355-361.
11. David, M., E. Petricoin III, C. Benjamin, R. Pine, M.J. Weber, and A.C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in Interferon α-and Interferon β-stimulated gene expression through STAT proteins. Science 269: 1721-1723.
12. Davis, R.J. 1993. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268: 14553-14556.
13. _. 1994. MAPKs: New JNK expands the group. Trends Biochem. Sci. 19: 470-473.
14. Dérijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis. 1994. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037.
15. Feinstein, S.C., S.L. Dana, L. McConlogue, E.M. Shooter, and P. Coffino. 1985. Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc. Natl. Acad. Sci. 82: 5761-5765.
16. Fu, X.-Y. 1992. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s). Cell 70: 323-335.
17. Fu, X.-Y. and J.-J. Zhang. 1993. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell 74: 1135-1145.
18. Ghosh, S. and D. Baltimore. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344: 678-682.
19. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358: 414-417.
20. Granelli-Piperno, A., L. Andrus, and R.M. Steinman. 1986. Lymphokine and nonlymphokine mRNA levels in stimulated human T cells: Kinetics, mitogen requirements, and effects of cyclosporin A. J. Exp. Med. 163: 922-937.
21. Greenberg, M.E., L.A. Greene, and E.B. Ziff. 1985. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J. Biol. Chem. 260: 14101-14110.
22. Greenberg, M.E. and E.B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311: 433-38.
23. Harlow, E. and D. Lane. 1988. Antibodies; A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
24. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein-and UV-responsive protein kinase that hinds and potentiates the c-Jun activation domain. Genes & Dev. 7: 2135-2148.
25. Hill, C.S. and R. Treisman. 1995. Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80: 199-211.
26. Huang, H.-C., R. Sundseth, and U. Hansen. 1990. Transcription factor LSF binds two variant bipartite sites within the SV40 late promoter. Genes & Dev. 4: 287-298.
27. Hunter, T. 1995. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling. Cell 80: 225-236.
28. Hunter, T. and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70: 375-387.
29. Janknecht, R., R.A. Hipskind, T. Houthaeve, A. Nordheim, and H.G. Stunnenberg. 1992. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J. 11: 1045-1054.
30. Jones, K.A., P.A. Luciw, and N. Duchange. 1988. Structural arrangements of transcription control domains within the 5′ -untranslated leader regions of the HIV-1 and HIV-2 promoters. Genes & Dev. 2: 1101-1114.
31. Kahana, C. and D. Nathans. 1984. Isolation of cloned cDNA encoding mammalian ornithine decarboxylase. Proc. Natl. Acad. Sci. 81: 3645-3649.
32. Kapiloff, M.S., Y. Farkash, M. Wegner, and M.G. Rosenfeld. 1991. Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. Science 253: 786-789.
33. Kato, H., M. Horikoshi, and R.G. Roeder. 1991. Repression of HIV-1 transcription by a cellular protein. Science 251: 1476-1479.
34. Katz, A. and C. Kahana. 1987. Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth. Mol. Cell. Biol. 7: 2641-2643.
35. Klimczak, L.J., U. Schindler, and A.R. Cashmore. 1992. DNA-binding activity of the Arabidopsis G-box binding factor GBF1 is stimulated by phosphorylation by casein kinase II from broccoli. Plant Cell 4: 87-98.
36. Lim, L.C., S.L. Swendeman, and M. Sheffery. 1992. Molecular cloning of the α-globin transcription factor CP2. Mol. Cell. Biol. 12: 828-835.
37. Lin, A., J. Frost, T. Deng, T. Smeal, N. Al-Alawi, U. Kikkawa, T. Hunter, D. Brenner, and M. Karin. 1992. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70: 777-789.
38. Malim, M.H., R. Fenrick, D.W. Ballard, J. Hauber, E. Böhnlein, and B.R. Cullen. 1989. Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region. J. Virol. 63: 3213-3219.
39. Manak, J.R. and R. Prywes. 1991. Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II Mol. Cell. Biol. 11: 3652-3659.
40. Mar, P.K., A.P. Kumar, D.-C. Kang, B. Zhao, L.A. Martinez, R.L. Montgomery, L. Anderson, and A.P. Butler. 1995. Characterization of novel phorbol ester-and serum-responsive sequences of the rat ornithine decarboxylase gene promoter. Mol. Carcinogen. 14: 240-250.
41. Marais, R.M., J.J. Hsuan, C. McGuigan, J. Wynne, and R. Treisman. 1992. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO J. 11: 97-105.
42. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73: 381-393.
43. Minden, A., A. Lin, T. Smeal, B. Dérijard, M. Cobb, R. Davis, and M. Karin. 1994. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14: 6683-6688.
44. Moll, T., G. Tebb, U. Surana, H. Robitsch, and K. Nasmyth. 1991. The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66: 743-758.
45. Montminy, M. 1993. Trying on a new pair of SH2s. Science 261: 1694-1695.
46. 3H1 muscle cell line. Mol. Cell. Biol. 6: 2792-2799.
47. Pulverer, B.J., J.M. Kyriakis, J. Avruch, E. Nikolakaki, and J.R. Woodgett. 1991. Phosphorylation of c-jun mediated by MAP kinases. Nature 353: 670-674.
48. Rao, A. 1991. Signaling mechanisms in T cells. Crit. Rev. Immunol. 10: 495-519.
49. Reed, J.C., J.D. Alpers, P.C. Nowell, and R.G. Hoover. 1986. Sequential expression of protooncogenes during lectinstimulated mitogenesis of normal human lymphocytes. Proc. Natl. Acad. Sci. 83: 3982-3986.
50. Reed, J.C., J.D. Alpers, P.A. Scherle, R.G. Hoover, P.C. Nowell, and M.B. Prystowsky. 1987. Proto-oncogene expression in cloned T lymphocytes: Mitogens and growth factors induce different patterns of expression. Oncogene 1: 223-228.
51. Rivera, V.M., C.K. Miranti, R.P. Misra, D.D. Ginty, R.-H. Chen, J. Blenis, and M.E. Greenberg. 1993. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol. Cell. Biol. 13: 6260-6273.
52. Roberts, S.B., N. Segil, and N. Heintz. 1991. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science 253: 1022-1026.
53. Segil, N., S.B. Roberts, and N. Heintz. 1991. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254: 1814-1816.
54. Sells, M.A. and J. Chernoff. 1995. Epitope-tag vectors for eukaryotic protein production. Gene 152: 187-189.
55. Shirodkar, S., M. Ewen, J.A. DeCaprio, J. Morgan, D.M. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68: 157-166.
56. Shirra, M.K., Q. Zhu, H.-C. Huang, D. Pallas, and U. Hansen. 1994. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. Mol. Cell. Biol. 14: 5076-5087.
57. Shirra, M.K. 1995. "Characterization of DNA-binding and oligomerization properties of the mammalian transcription factor LSF." Ph.D. thesis, Harvard University, Cambridge, MA.
58. Shuai, K., G.R. Stark, I.M. Kerr, and J.E. Darnell, Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261: 1744-1746.
59. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-736.
60. Tanaka, M., R. Gupta, and B.J. Mayer. 1995. Differential inhibition of signaling pathways by dominant-negative SH2/ SH3 adapter proteins. Mol. Cell. Biol. 15: 6829-6837.
61. Uv, A.E., C.R.L. Thompson, and S.J. Bray. 1994. The Drosophila tissue-specific factor grainyhead contains novel DNA-binding and dimerization domains which are conserved in the human protein CP2. Mol. Cell. Biol 14: 4020-4031.
62. Vojtek, A.B. and J.A. Cooper. 1995. Rho family members: Activators of MAP kinase cascades. Cell 82: 527-529.
63. Wen, Z., Z. Zhong, and J.E. Darnell Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
64. Wu, F.K., J.A. Garcia, D. Harrich, and R.B. Gaynor. 1988. Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1. EMBO J. 7: 2117-2129.
65. Yoon, J.-B., G. Li, and R.G. Roeder. 1994. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. Mol. Cell. Biol. 14: 1776-1785.