Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 1, 2010, Pages 267-272

  Heinemann, Ilka U ^a   Schulz, Claudia ^a   Schubert, Wolf Dieter ^b,c   Heinz, Dirk W ^b   Wang, Yang G ^d   Kobayashi, Yuichi ^d   Awa, Yuuki ^d   Wachi, Masaaki ^d   Jahn, Dieter ^a   Jahn, Martina ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 ACETAMIDO 4 OXO 5 HEXENOIC ACID; ALAREMYCIN; AMINO ACID; AMINOCAPROIC ACID DERIVATIVE; ANTIBIOTIC AGENT; HEME; LYSINE; PORPHOBILINOGEN SYNTHASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOSYNTHESIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG STRUCTURE; DRUG TARGETING; ENZYME STRUCTURE; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

AMINOCAPROIC ACIDS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; CRYSTALLIZATION; DRUG RESISTANCE, BACTERIAL; GENETIC VECTORS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEME; KINETICS; MAGNESIUM; METHANOSARCINA BARKERI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PORPHOBILINOGEN SYNTHASE; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; ZINC;

EID: 73849132820     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00553-09     Document Type: Article

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