Tracking the evolution of porphobilinogen synthase metal dependence in vitro

Journal of Molecular Biology

Volumn 345, Issue 5, 2005, Pages 1059-1070

  Frère, Frederic ^a   Reents, Heike ^a   Schubert, Wolf Dieter ^b   Heinz, Dirk W ^b   Jahn, Dieter ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

crystal structure; evolution; metalloenzyme; porphobilinogen synthase; Pseudomonas aeruginosa

Indexed keywords

ALANINE; AMINO ACID; ASPARTIC ACID; CYSTEINE; ENZYME; ENZYME VARIANT; METAL; PORPHOBILINOGEN SYNTHASE; TETRAPYRROLE DERIVATIVE; ZINC ION;

AMINO ACID SUBSTITUTION; ARTICLE; BIOSYNTHESIS; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ESCHERICHIA COLI; EVOLUTION; IN VITRO STUDY; MUTANT; MYCOBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SITE DIRECTED MUTAGENESIS;

ESCHERICHIA COLI; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 11844251357     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.10.053     Document Type: Article

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