Activated Protein C Attenuates Intestinal Mucosal Injury After Mesenteric Ischemia/Reperfusion

Journal of Surgical Research

Volumn 149, Issue 2, 2008, Pages 219-230

  Teke, Zafer ^a   Sacar, Mustafa ^a   Yenisey, Cigdem ^b   Atalay, A Ozgur ^a   Kavak, Tulay ^b   Erdem, Ergun ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

activated protein C; catalase; glutathione; glutathione peroxidase; glutathione reductase; ischemia reperfusion; malondialdehyde; mesenteric ischemia; mucosal injury; myeloperoxidase; nitrate nitrite; reperfusion injury; xanthine oxidase

Indexed keywords

CATALASE; D DIMER; DROTRECOGIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; NITRATE; NITRITE; OXIDOREDUCTASE; TUMOR NECROSIS FACTOR ALPHA; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; INTESTINE INJURY; INTESTINE MUCOSA; ISCHEMIA; LAPAROTOMY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION; SURVIVAL;

ANIMALS; ANTICOAGULANTS; EDEMA; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GLUTATHIONE; GLUTATHIONE REDUCTASE; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; MALONDIALDEHYDE; MESENTERIC ARTERY, SUPERIOR; MESENTERIC VASCULAR OCCLUSION; NITRATES; NITRITES; PEROXIDASES; PROTEIN C; RATS; RATS, WISTAR; REPERFUSION INJURY; TUMOR NECROSIS FACTOR-ALPHA; WARM ISCHEMIA; XANTHINE OXIDASE;

EID: 51049099391     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.10.011     Document Type: Article

References (34)

1. Schoots I.G., Levi M., Roossink E.H., et al. Local intravascular coagulation and fibrin deposition on intestinal ischemia-reperfusion in rats. Surgery 133 (2003) 411
2. Mizutani A., Okajima K., Uchiba M., et al. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95 (2000) 3781
3. Hirose K., Okajima K., Taoka Y., et al. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg 232 (2000) 272
4. Yamaguchi Y., Hisama N., Okajima K., et al. Pretreatment with activated protein C or active human urinary thrombomodulin attenuates the production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion in rat liver. Hepatology 25 (1997) 1136
5. Taylor Jr. F.B., Chang A., Esmon C.T., et al. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 79 (1987) 918
6. Bernard G.R., Vincent J.L., Laterre P.F., et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344 (2001) 699
7. Grey S.T., Csizmadia V., and Hancock W.W. Differential effect of tumor necrosis factor-α on thrombomodulin gene expression by human monocytoid (THP-1) cells versus endothelial cells. Int J Hematol 67 (1998) 53
8. Murakami K., Okajima K., Uchiba M., et al. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol 272 (1997) 197
9. Gollin G., Zieg P.M., Cohn S.M., et al. Intestinal mucosal injury in critically ill surgical patients: Preliminary observations. Am Surg 65 (1999) 19
10. Stechmiller J.K., Treloar D., and Allen N. Gut dysfunction in critically ill patients: A review of the literature. Am J Crit Care 6 (1997) 204
11. Kuzu M.A., Tanik A., Kale I.T., et al. Effect of ischemia/reperfusion as a systemic phenomenon on anastomotic healing in the left colon. World J Surg 24 (2000) 990
12. Schoots I.G., Levi M., van Vliet A.K., et al. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit Care Med 32 (2004) 1375
13. Chiu C.J., McArdle A.H., Brown R., et al. Intestinal mucosal lesions in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 101 (1970) 478
14. Suzuki K., Ota H., Sasagawa S., et al. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 132 (1983) 345
15. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95 (1979) 351
16. Prajda N., and Weber G. Malignant transformation-linked imbalance: Decreased xanthine oxidase activity in hepatomas. FEBS Lett 59 (1975) 245
17. Navarro-Gonzalves J.A., Garcia-Benayas C., and Arenas J. Semiautomated measurement of nitrate in biological fluids. Clin Chem 44 (1998) 679
18. Ellman G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 82 (1959) 70
19. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70 (1967) 158
20. Racker E. Glutathione reductase from bakers' yeast and beef liver. J Biol Chem 217 (1955) 855
21. Hazelton G.A., and Lang C.A. Glutathione peroxidase and reductase activities in the aging mouse. Mech Aging Dev 29 (1985) 71
22. Aebi H. Catalase in vitro. Meth Enzymol 105 (1984) 121
23. Mallick I.H., Yang W., Winslet M.C., et al. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49 (2004) 1359
24. Li X.K., Suzuki H., Kimura T., et al. Ulinastatin, a protease inhibitor, attenuates intestinal ischemia/reperfusion injury. Transplant Proc 26 (1994) 2423
25. Schmeling D.J., Caty M.G., Oldham K.T., et al. Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery 106 (1989) 195
26. Koksoy C., Kuzu M.A., Ergun H., et al. Intestinal ischemia and reperfusion impairs vasomotor functions of pulmonary vascular bed. Ann Surg 231 (2000) 105
27. Shen L., and Zhang J. Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils. Neurosci Lett 344 (2003) 1
28. Cheng T., Liu D., Griffin J.H., et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9 (2003) 338
29. Isobe H., Okajima K., Uchiba M., et al. Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation 104 (2001) 1171
30. Gupta A., Rhodes G.J., Berg D.T., et al. Activated Protein C ameliorates LPS-induced acute kidney injury and down-regulates renal iNOS and angiotensin 2. Am J Physiol Renal Physiol 293 (2007) 245
31. Grey S., Hau H., Salem H.H., et al. Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-γ, or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction. Transplant Proc 25 (1993) 2913
32. Yuksel M., Okajima K., Uchiba M., et al. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Thromb Hemost 88 (2002) 267
33. Schwartz M.D., Repine J.E., and Abraham E. Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock. Am J Respir Cell Mol Biol 12 (1995) 434
34. Bertuglia S., and Colantuoni A. Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 278 (2000) 755