Embryo-fetal developmental toxicity study design for pharmaceuticals

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 86, Issue 6, 2009, Pages 418-428

  Wise, L David ^a   Buschmann, Jochen ^b   Feuston, Maureen H ^c   Fisher, J Edward ^d   Hew, Kok Wah ^e   Hoberman, Alan M ^f   Lerman, Steven A ^g   Ooshima, Yojiro ^h   Stump, Donald G ⁱ  

^a MERCK RESEARCH LABORATORIES   (United States)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c US Inc   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e TAKEDA PHARMACEUTICALS   (United States)

^f CHARLES RIVER LABORATORIES   (United States)

^g GLAXOSMITHKLINE   (United States)

^h SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

ⁱ WIL RESEARCH LABORATORIES   (United States)

Author keywords

Developmental toxicity; Embryo fetal development; Hazard assessment; Safety assessment; Teratogenicity

Indexed keywords

BLOOD CHEMISTRY; BONE DEVELOPMENT; CESAREAN SECTION; CLINICAL RESEARCH; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; EXPERIMENTAL MODEL; FEMALE FERTILITY; FETOTOXICITY; FETUS DEVELOPMENT; FOOD INTAKE; HAZARD ASSESSMENT; NONHUMAN; ORGAN WEIGHT; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; TERATOGENICITY; TOXICOKINETICS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANIMALS, INBRED STRAINS; DRUG EVALUATION, PRECLINICAL; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; INTERNATIONAL AGENCIES; INTERNATIONAL COOPERATION; MALE; MATERNAL EXPOSURE; MICE; PHARMACEUTICAL PREPARATIONS; RABBITS; RATS; RESEARCH DESIGN; TOXICITY TESTS;

ORYCTOLAGUS CUNICULUS; RODENTIA;

EID: 73649148013     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20214     Document Type: Review

References (49)

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