Cardiovascular effects of oral toluene exposure in the rat monitored by radiotelemetry

Neurotoxicology and Teratology

Volumn 29, Issue 2, 2007, Pages 228-235

  Gordon, Christopher J ^a   Samsam, Tracey E ^a   Oshiro, Wendy M ^a   Bushnell, Philip J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Heart rate; Radiotelemetry; Tachycardia; Volatile organic compounds

Indexed keywords

TOLUENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; CORE TEMPERATURE; HEART RATE; IMPLANT; LONG EVANS RAT; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; TACHYCARDIA; TELEMETRY;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; MALE; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; SOLVENTS; TELEMETRY; TOLUENE;

ANIMALIA; RATTUS;

EID: 33947162593     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2006.10.004     Document Type: Article

References (22)

1. Bass M. Sudden sniffing death. J. Am. Med. Assoc. 212 (1970) 2075-2079
2. Benignus V.A. Health effects of toluene: a review. Neurotoxicology 2 (1981) 567-588
3. Berenguer P., Soulage C., Perrin D., Pequignot J.-M., and Abraini J.H. Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats. Pharmacol. Biochem. Behav. 74 (2003) 997-1003
4. Castilla-Serna L., Barragan-Mejia M.G., Rodriguez-Perez R.A., Carcia Rillo A., and Reyes-Vazquez C. Effects of acute and chronic toluene inhalation on behavior, monoamine metabolisms and specific binding (3H-serotonin and 3H-norepinephrine) of rat brain. Arch. Med. Res. 24 (1993) 169-176
5. Einav S., Amitai Y., Reichman J., and Geber D. Bradycardia in toluene poisoning. J. Toxicol. Clin. Toxicol. 35 (1997) 295-299
6. Ideda N., Takahashi H., Umetsu K., and Suzuki T. The course of respiration and circulation in "toluene-sniffing". Forensic Sci. Int. 44 (1990) 151-158
7. Gerkin Jr. R.D., and LoVecchio F. Rapid reversal of life-threatening toluene-induced hypokalemia with hemodialysis. J. Emerg. Med. 16 (1998) 723-725
8. Gordon C.J. Acute and delayed effects of diisopropyl fluorophosphate (DFP) on body temperature, heart rate, and motor activity in awake, unrestrained rats. J. Toxicol. Environ. Health 39 (1993) 247-260
9. Gordon C.J. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach (2005), CRC Press, Boca Raton, FL
10. Gospe, and Al-Bayati M.A.S. Comparison of oral and inhalation exposures to toluene. J. Am. Coll. Toxicol. 13 (1994) 21-32
11. Ishi R., Harabuchi I., Katakura Y., Ikeda T., and Miyake H. Neurobehavioral effects of chronic occupational exposure to organic solvents among Japanese industrial painters. Environ. Res. 62 (1993) 303-313
12. Morvai V., Hudak A., Ungvary G., and Varga B. ECG changes in benzene, toluene and xylene poisoned rats. Acta med. Acad. Sci. Hung. 33 (1976) 275-286
13. Oshiro W.M., Samsam T.E., Krantz Q.T., Watkinson W.P., and Bushnell P.J. Age-related Differences in Heart Rate, But Not Body Temperature, in Rats Performing Operant Tasks at Equivalent Trial Rates in Air and While Inhaling Toluene (March 2003), Society of Toxicology, Salt Lake City, UT
14. Reinhardt C.F., Azar A., Maxfield M.E., Smith Jr. P.E., and Mullin L.S. Cardiac arrhythmias and aerosol "sniffing. Arch. Environ. Health 22 (1971) 265-279
15. Smith E.G., and Gordon C.J. The effects of chlorpyrifos on blood pressure and temperature regulation in spontaneously hypertensive rats. Basic Clin. Pharmacol. Toxicol. 96 (2005) 503-511
16. Soulage C., Perrin D., Berenguer P., and Pequignot J.M. Sub-chronic exposure to toluene at 40 ppm alters the monamine biosynthesis rate in discrete brain areas. Toxicology 196 (2004) 21-30
17. Sullivan M.J., and Conolly R.B. Comparison of blood toluene levels after inhalation and oral administration. Environ. Res. 45 (1988) 64-70
18. Taylor G.J., and Harris W.S. Glue sniffing causes heart block in mice. Science 170 (1970) 866-877
19. Vidrio H., Magos G.A., and Lorenzana-Jimenez M. Electrocardiographic effects of toluene in the anesthetized rat. Arch. Int. Pharmacodyn. 279 (1986) 121-129
20. Von Euler M., Pham T.M., Hillefors M., Bjelke B., Henriksson B., and von Euler G. Inhalation of low concentrations of toluene induces persistent effects on a learning retention task, beam-walk performance, and cerebrocortical size in the rat. Exp. Neurol. 163 (2000) 1-8
21. Yamawaki S., Segawa T., and Sarai K. Effects of acute and chronic toluene inhalation on behavior and (3H)-serotonin binding in rat. Life Sci. 30 (1982) 1997-2002
22. Yang Y., and Gordon C.J. Ambient temperature limits and stability of temperature regulation in telemetered male and female rats. J. Therm. Biol. 21 (1996) 353-363