Effect of α2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 1, 2010, Pages 219-224

  Kiive, Evelyn ^a   Kurrikoff, Triin ^a   Mäestu, Jarek ^a   Harro, Jaanus ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

ADHD symptoms; Alpha 2A adrenoreceptor; Family relations; Gene polymorphism; Noradrenergic system

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ADOLESCENT; AGGRESSION; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DISTURBANCE; CHILD ABUSE; CHILD BEHAVIOR; CONTROLLED STUDY; FAMILY INTERACTION; FAMILY RELATION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPERACTIVITY; HYPERACTIVITY SCALE OF AF KLINTEBERG; MALE; MENTAL CONCENTRATION; PROMOTER REGION; RATING SCALE; RESTLESSNESS; SELF REPORT; TEACHER; ANALYSIS OF VARIANCE; COHORT ANALYSIS; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOSPITALIZATION; PATHOPHYSIOLOGY; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; RETROSPECTIVE STUDY;

ADOLESCENT; ANALYSIS OF VARIANCE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD ABUSE; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; PSYCHOLOGICAL TESTS; RECEPTORS, ADRENERGIC, ALPHA-2; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 73649120573     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.11.011     Document Type: Article

References (45)

1. Abercrombie E.D., and Jacobs B.L. Sinle unit response of noradrenergic neurons in the locus coeruleus of freely moving cats: I. Acutely presented stressful and nonstressful stimuli. J Neurosci 7 (1987) 2837-2843
2. af Klinteberg B. Studies on sex-related psychological and biological indicators of psychosocial vulnerability: a developmental perspective (1988), Department of Psychology, University of Stockholm
3. af Klinteberg B., and Oreland L. Hyperactive and aggressive behaviors in childhood as related to low platelet monoamine oxidase (MAO) activity at adult age: a longitudinal study of male subjects. Pers Individ Differ 19 (1995) 373-383
4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (1994), American Psychiatric Association
5. Aoki C., Venkatesan C., Go C.G., Forman R., and Kurose H. Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons. Cereb Cortex 8 (1998) 269-277
6. Arnsten A.F., and Li B.M. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 57 (2005) 1377-1384
7. Arnsten A.F., Mathew R., Ubriani R., Taylor J.R., and Li B.M. Alpha-1 noradrenergic receptor stimulation impairs cortical cognitive function. Biol Psychiatry 45 (1999) 26-31
8. Barkley R.A. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121 (1997) 65-94
9. Biederman J., and Spencer T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46 (1999) 1234-1242
10. Callado L.F., and Stamford J.A. Alpha2A- but not alpha 2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur J Pharmacol 366 (1999) 35-39
11. Cheon K.A., Cho D.Y., Koo M.S., Song D.H., and Namkoong K. Associations between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. Biol Psychiatry 65 (2009) 564-570
12. Cho S.C., Kim J.W., Kim B.N., Hwang J.W., Park M., Kim S.A., et al. Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder. Am J Med Genet (Neuropsychiatr Genet) 147 (2008) 957-963
13. Comings D.E., Johnson J.P., Gonzales N.S., Huss M., Saucier G., McGue M., et al. Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Psychiatr Genet 10 (2000) 39-42
14. da Silva T.L., Pianca T.G., Roman T., Hutz M.H., Faraone S.V., Schmitz M., et al. Adrenergic α2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type. J Neural Transm 115 (2008) 341-345
15. Famularo R., Kinscherff R., and Fenton T. Psychiatric diagnoses of maltreated children: preliminary findings. J Am Acad Child Adolesc Psych 31 (1992) 863-867
16. Halperin J.M., Newcorn J.H., Koda V.H., Pick L., McKay K.E., and Knott P. Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension. J Am Acad Child Adolesc Psych 36 (1997) 1688-1696
17. Harro J., and Oreland L. Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus. Brain Res Rev 38 (2001) 79-128
18. Harro M., Eensoo D., Kiive E., Merenäkk L., Alep J., Oreland L., et al. Platelet monoamine oxidase in healthy 9- and 15-years old children: the effect of gender, smoking and puberty. Prog Neuropsychopharmacol Biol Psychiatry 25 (2001) 1497-1511
19. Harro J., Paaver M., Kiive E., Mäestu J., and Parik J. Attention deficit symptoms, visual information processing, and the ADRA2A C-1291C polymorphism in a population derived sample of children and adolescents. J Neural Transm 114 (2007) 85
20. Johnston C., and Mash E.J. Families of children with attention deficit/hyperactivity disorder: review and recommendations for future research. Clin Child Fam Psychol Rev 4 (2001) 183-207
21. Lafontan M., and Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34 (1993) 1057-1092
22. Lario S., Calls J., Cases A., Oriola J., Torras A., and Rivera F. MspI identifies a biallelic polymorphism in the promoter region of the 2A-adrenergic receptors. Clin Genet 51 (1997) 129-130
23. Mäestu J., Villa I., Parik J., Paaver P., Merenäkk L., Eensoo D., et al. Human adrenergic alpha 2A receptor C-1291G polymorphism leads to higher consumption of sweet food products. Mol Psychiatry 12 (2007) 520-521
24. Mäestu J., Allik J., Merenäkk L., Eensoo D., Parik J., Veidebaum T., et al. Associations between an alpha 2a adrenergic receptor gene polymorphism and adolescent personality. Am J Med Genet (Neuropsychiatr Genet) 147 (2008) 418-423
25. Magnusson D., Duner A., and Zetterblom G. Adjustment: a longitudinal study (1975), Almquist & Wiksell, Stockholm
26. Meyer H., Palchaudhuri M., Scheinin M., and Flügge G. Regulation of alpha(2A)-adrenoceptor expression by chronic stress in neurons of the brain stem. Brain Res 880 (2000) 147-158
27. Ouyang L., Fang X., Mercy J., Perou R., and Grosse S.D. Attention-deficit/hyperactivity disorder symptoms and child maltreatment: a population-based study. J Pediatr 153 (2008) 851-856
28. Paaver M., Kurrikoff T., Nordquist N., Oreland L., and Harro J. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatry 32 (2008) 1263-1268
29. Park L., Nigg J., Waldman I.D., Nummy K.A., Huang-Pollock C., Rappley M., et al. Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD. Mol Psychiatry 10 (2005) 572-580
30. Polanczyk G., Zeni C., Genro J.P., Guimarães A.P., Roman T., Hutz M.H., et al. Association of the adrenergic alpha 2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 64 (2007) 218-224
31. Roman T., Schmitz M., Polanczyk G.V., Eizirik M., Rohde L.A., and Hutz M.H. Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?. Am J Med Genet (Neuropsychiatr Genet) 120 (2003) 116-120
32. Rosmond R., Bouchard C., and Björntorp P. A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. J Int Med 251 (2002) 252-257
33. Rutter M., Moffitt T.E., and Caspi A. Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry 47 (2006) 226-261
34. Scheibner J., Trendelenburg A., Hein L., and Starke K. Alpha(2)-adrenoceptors modulating neuronal serotonin release: a study in alpha(2)-adrenoceptor subtype-deficient mice. Br J Pharmacol 132 (2001) 925-933
35. 2-adrenoceptor blockade. Neuropsychopharmacology 16 (1997) 298-310
36. Schmitz M., Denardin D., Silva E.L., Pianca T., Roman T., Hutz M.H., et al. Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type. Biol Psychiatry 60 (2006) 1028-1033
37. Sheese B.E., Voelker P.M., Rothbart M.K., and Posner M.I. Parenting quality interacts with genetic variation in dopamine receptor D4 to influence temperament in early childhood. Dev Psychopathol 19 (2007) 1039-1046
38. Solanto M.V. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 94 (1998) 127-152
39. Sonuga-Barke E.J.S., Lasky-Su J., Neale B.M., Oades R., Chen W., Franke B., et al. Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan. Am J Med Genet (Neuropsychiatr Genet) 147 (2008) 1359-1368
40. Starke K. Presynaptic autoreceptors in the third decade: focus on alpha2-adrenoceptors. J Neurochem 78 (2001) 685-693
41. Swanson J.M., Kraemer H.C., Hinshaw S.P., Arnold L.E., Conners C.K., and Abikoff H.B. Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psych 40 (2001) 168-179
42. Thapar A., Langley K., Asherson P., and Gill M. Gene-environment interplay in attention deficit hyperactivity disorder and the importance of a developmental perspective. Br J Psychiatry 190 (2007) 1-3
43. Van Gaalen M., Kawahara H., Kawahara Y., and Westerink B.H. The locus coeruleus noradrenergic system in the rat brain studied by dual probe microanalysis. Brain Res 763 (1997) 56-62
44. Wang B., Wang Y., Zhou R., Li J., Qian Q., Yang L., et al. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/ hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 141 (2006) 130-134
45. Xu C., Schachar R., Tannock R., Roberts W., Malone M., Kennedy J.L., et al. Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families. Am J Med Genet 105 (2001) 159-162