Adrenergic α2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type

Journal of Neural Transmission

Volumn 115, Issue 2, 2008, Pages 341-345

  Da Silva, T L ^a   Pianca, T G ^a   Roman, T ^b   Hutz, M H ^c   Faraone, S V ^d   Schmitz, M ^a   Rohde, L A ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b Federal School of Medical Sciences of Porto Alegre   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

ADRA2A gene; Attention deficit hyperactivity disorder; Inattentive type; Methylphenidate; Pharmacogenetics

Indexed keywords

ADRENERGIC ALPHA2A RECEPTOR; ALPHA ADRENERGIC RECEPTOR; METHYLPHENIDATE; UNCLASSIFIED DRUG; ALPHA 2 ADRENERGIC RECEPTOR; CENTRAL STIMULANT AGENT;

ADOLESCENT; ADULT; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHILD PSYCHIATRY; CONTROLLED STUDY; DRUG RESPONSE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; TREATMENT DURATION; ANALYSIS OF VARIANCE; CLASSIFICATION; CLINICAL TRIAL; FEMALE; GENE FREQUENCY; GENETICS; PHARMACOGENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ALLELES; ANALYSIS OF VARIANCE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; FEMALE; GENE FREQUENCY; HUMANS; MALE; METHYLPHENIDATE; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 39549085981     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0835-0     Document Type: Article

References (28)

1. AF Arnsten AG Dudley 2005 Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder Behav Brain Funct 1 2
2. AF Arnsten BM Li 2005 Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions Biol Psychiatry 57 1377 1384
3. AF Arnsten JC Steere RD Hunt 1996 The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function: potential significance for attentiondeficit hyperactivity disorder Arch Gen Psychiatry 53 448 455
4. I Belfer B Buzas H Hipp G Phillips J Taubman I Lorincz C Evans RH Lipsky MA Enoch MB Max D Goldman 2005 Haplotype-based analysis of _ 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene J Hum Genet 50 12 20
5. J Biederman T Spencer 1999 Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder Biol Psychiatry 46 1234 1342
6. SV Faraone RH Perlis AE Doyle JW Smoller JJ Goralnick MA Holmgren P Sklar 2005 Molecular genetics of attention-deficit/hyperactivity disorder Biol Psychiatry 57 11 1313 1323 Jun 1
7. S Friedel K Saar S Sauer A Dempfle S Walitza T Renner M Romanos C Freitag C Seitz H Palmason A Scherag C Windemuth-Kieselbach BG Schimmelmann C Wewetzer J Meyer A Warnke KP Lesch R Reinhardt B Herpertz-Dahlmann M Linder A Hinney H Remschmidt H Schafer K Konrad N Hubner J Hebebrand 2007 Association and linkage of allelic variants of the dopamine transporter gene in ADHD Mol Psychiatry 12 10 923 33 Oct
8. LS Goldman M Genel RJ Bezman PJ Slanetz 1998 Council on Scientific Affairs, American Medical Association Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents JAMA 279 1100 1107
9. J Hebebrand A Dempfle K Saar H Thiele B Herpertz-Dahlmann M Linder H Kiefl H Remschmidt U Hemminger A Warnke U Knolker P Heiser S Friedel A Hinney H Schafer P Nurnberg K Konrad 2006 A genome-wide scan for attention-deficit/ hyperactivity disorder in 155 German sib-pairs Mol Psychiatry 11 2 196 205 Feb
10. SA Khan SV Faraone 2006 The genetics of ADHD: a literature review of 2005 Curr Psychiatry Rep 8 5 393 397
11. JH Kurth 2000 Pharmacogenomics: a genetic tool for identifying patients at risk Drug Inform J 34 223 227
12. MD Lapiz DA Morilak 2006 Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability Neurosci 137 3 1039 1049 Feb
13. S Lario J Calls A Cases J Oriola A Torras F Rivera 1997 MspI identifies a biallelic polymorphism in the promoter region of the alpha2A-adrenergic receptor gene Clin Genet 51 129 130
14. JS Markowitz AB Straughn KS Patrick 2003 Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations Pharmacotherapy 23 10 1281 1299 Oct
15. JJ McGough 2005 Attention-deficitthyperactivity disorder pharmacogenomics Biol Psychiatry 57 1367 1373
16. L Park JT Nigg ID Waldman KA Nummy C Huang-Pollock M Rappley KH Friderici 2005 Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD Mol Psychiatry 10 572 580
17. G Polanczyk MS de Lima BL Horta J Biederman LA Rohde 2007a The worldwide prevalence of ADHD: a systematic review and metaregression analysis Am J Psychiatry 164 6 942 948 Jun
18. G Polanczyk C Zeni J Genro AP Guimarães T Roman MH Hutz LA Rohde 2007b Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder Arch Gen Psychiatry 64 218 224
19. G Polanczyk C Zeni JP Genro T Roman MH Hutz LA Rohde 2005 Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics Pharmacogenomics 6 3 225 234
20. T Roman G Polanczyk C Zeni J Genro LA Rohde M Hutz 2006 Further evidence of the involvement of alpha-2A-adrenergic receptor gene (ADRA2A) in inattentive dimensional scores of ADHD Mol Psychiatry 11 8 10
21. T Roman M Schmitz GV Polanczyk M Eizirik LA Rohde MH Hutz 2003 Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention deficit/hyperactivity disorder? Am J Med Genet B Neuropsychiatr Genet 120 116 120
22. M Schmitz D Denardin TL Silva T Pianca T Roman M Hutz SV Faraone LA Rohde 2006a Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type Biol Psychiatry 60 1028 1033
23. M Schmitz D Denardin TL Silva T Pianca M Hutz S Faraone LA Rohde 2006b Smoking during pregnancy and ADHD inattentive type: a case-control study J Am Acad Child Adolesc Psychiatry 45 1338 1345
24. T Spencer J Biederman T Wilens M Harding D O'Donnell S Griffin 1996 Pharmacotherapy of attention deficit hyperactivity disorder across the lifespan J Am Acad Child Adolesc Psychiatry 35 409 428
25. J Stevens AL Quittner H Abikoff 1998 Factors influencing elementary school teachers' rating ADHD and ODD behaviors J Clin Child Psychol 27 406 414
26. JM Swanson HC Kraemer SP Hinshaw LE Arnold CK Conners HB Abikoff W Clevenger M Davies GR Elliott LL Greenhill L Hechtman B Hoza PS Jensen JS March JH Newcorn EB Owens WE Pelham E Schiller JB Severe S Simpson B Vitiello K Wells T Wigal M Wu 2001 Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment J Am Acad Child Adolesc Psychiatry 40 168 179
27. ID Waldman JT Nigg IR Gizer L Park MD Rappley K Friderici 2006 The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD Cogn Affect Behav Neurosci 6 18 30
28. Wechsler D: WISC III/Manual (1991) The psychological corporation. New York, NY