Drosophotoxicology: The growing potential for Drosophila in neurotoxicology

Neurotoxicology and Teratology

Volumn 32, Issue 1, 2010, Pages 74-83

  Rand, Matthew D ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Arsenic; Drosophila; Ethanol; Genotoxicity; High throughput assays; Lead; Mercury; Notch; Quantitative trait loci; Reporter gene; Toxicogenomics

Indexed keywords

ALCOHOL; ARSENIC; BETA GALACTOSIDASE; CADMIUM; EPIDERMAL GROWTH FACTOR; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; LEAD; MERCURY; METHOTREXATE; METHYLMERCURY; NOTCH RECEPTOR; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; SONIC HEDGEHOG PROTEIN; STRONTIUM; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; EXPERIMENTAL MODEL; GENE DISRUPTION; GENE IDENTIFICATION; GENE INTERACTION; GENE TARGETING; GENETIC ANALYSIS; GENETIC CONSERVATION; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HORMESIS; LETHALITY; MAMMAL; MORPHOLOGY; MUTAGENICITY; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM FUNCTION; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; REPORTER GENE; REVIEW; SENSITIVITY ANALYSIS; SPECIES DIFFERENCE; TERATOGENICITY; TOXICITY TESTING;

ANIMALS; DROSOPHILA; HIGH-THROUGHPUT SCREENING ASSAYS; NERVOUS SYSTEM; SMALL MOLECULE LIBRARIES; TOXICITY TESTS;

MAMMALIA;

EID: 73649107634     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2009.06.004     Document Type: Review

References (105)

1. Abraham S.K. Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination. Mutagenesis 9 (1994) 383-386
2. Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., et al. The genome sequence of Drosophila melanogaster. Science (New York, NY) 287 (2000) 2185-2195
3. Affleck J., and Walker V. A role for Drosophila in understanding drug-induced cytotoxicity and teratogenesis. Cytotechnology 57 (2008) 1-9
4. Affleck J.G., Neumann K., Wong L., and Walker V.K. The effects of methotrexate on Drosophila development, female fecundity, and gene expression. Toxicological Sciences 89 (2006) 495-503
5. Affleck J.G., and Walker V.K. Transgenic rescue of methotrexate-induced teratogenicity in Drosophila melanogaster. Toxicological Sciences 99 (2007) 522-531
6. Arking R., and Parente A. Effects of RNA inhibitors on the development of Drosophila embryos permeabilized by a new technique. The Journal of Experimental Zoology 212 (1980) 183-194
7. Ashby J., and Tennant R.W. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutation research 257 (1991) 229-306
8. Ballinger D.G., and Benzer S. Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless. Proceedings of the National Academy of Sciences of the United States of America 85 (1988) 3960-3964
9. Barolo S., Castro B., and Posakony J.W. New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. BioTechniques 36 436-40 (2004) 442
10. Bijelic G., Kim N.R., and O'Donnell M.J. Effects of dietary or injected organic cations on larval Drosophila melanogaster: mortality and elimination of tetraethylammonium from the hemolymph. Archives of Insect Biochemistry and Physiology 60 (2005) 93-103
11. Bilen J., and Bonini N.M. Drosophila as a model for human neurodegenerative disease. Annual Review of Genetics 39 (2005) 153-171
12. Bodmer R., Carretto R., and Jan Y.N. Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages. Neuron 3 (1989) 21-32
13. Bossing T., Udolph G., Doe C.Q., and Technau G.M. The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm. Developmental Biology 179 (1996) 41-64
14. Bournias-Vardiabasis N., and Teplitz R.L. Use of Drosophila embryo cell cultures as an in vitro teratogen assay. Teratogenesis, Carcinogenesis, and Mutagenesis 2 (1982) 333-341
15. Bournias-Vardiabasis N., Teplitz R.L., Chernoff G.F., and Seecof R.L. Detection of teratogens in the Drosophila embryonic cell culture test: assay of 100 chemicals. Teratology 28 (1983) 109-122
16. Brand A.H., Manoukian A.S., and Perrimon N. Ectopic expression in Drosophila. Methods in Cell Biology 44 (1994) 635-654
17. Brand A.H., and Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (Cambridge, England) 118 (1993) 401-415
18. Branson K., Robie A.A., Bender J., Perona P., and Dickinson M.H. High-throughput ethomics in large groups of Drosophila. Nature Methods (2009)
19. Brewster R., and Bodmer R. Cell lineage analysis of the Drosophila peripheral nervous system. Developmental Genetics 18 (1996) 50-63
20. Budnik V. Synapse maturation and structural plasticity at Drosophila neuromuscular junctions. Current Opinion in Neurobiology 6 (1996) 858-867
21. Christie N.T., Williams M.W., and Jacobson K.B. Genetic and physiological parameters associated with cadmium toxicity in Drosophila melanogaster. Biochemical Genetics 23 (1985) 571-583
22. Cohen S.M., Arnold L.L., Eldan M., Lewis A.S., and Beck B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Critical reviews in Toxicology 36 (2006) 99-133
23. Collins F.S., Gray G.M., and Bucher J.R. Toxicology. Transforming environmental health protection. Science (New York, NY) 319 (2008) 906-907
24. Cooley L., Kelley R., and Spradling A. Insertional mutagenesis of the Drosophila genome with single P elements. Science (New York, NY) 239 (1988) 1121-1128
25. Cooper M.T., Tyler D.M., Furriols M., Chalkiadaki A., Delidakis C., and Bray S. Spatially restricted factors cooperate with notch in the regulation of enhancer of split genes. Developmental Biology 221 (2000) 390-403
26. Davis R.L. Olfactory memory formation in Drosophila: from molecular to systems neuroscience. Annual Review of Neuroscience 28 (2005) 275-302
27. Dicker A.P., Volkenandt M., and Bertino J.R. Detection of a single base mutation in the human dihydrofolate reductase gene from a methotrexate-resistant cell line using the polymerase chain reaction. Cancer Communications 1 (1989) 7-12
28. Dimitrijevic N., Dzitoyeva S., and Manev H. An automated assay of the behavioral effects of cocaine injections in adult Drosophila. Journal of Neuroscience Methods 137 (2004) 181-184
29. Dix D.J., Houck K.A., Martin M.T., Richard A.M., Setzer R.W., and Kavlock R.J. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicological Science 95 (2007) 5-12
30. do Amaral V.S., da Silva R.M., Reguly M.L., and de Andrade H.H. Drosophila wing-spot test for genotoxic assessment of pollutants in water samples from urban and industrial origin. Mutation Research 583 (2005) 67-74
31. Doe C.Q. Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development (Cambridge, England) 116 (1992) 855-863
32. Doe C.Q., and Skeath J.B. Neurogenesis in the insect central nervous system. Current Opinion in Neurobiology 6 (1996) 18-24
33. Domenech E., Manosa M., Navarro M., Masnou H., Garcia-Planella E., Zabana Y., Cabre E., and Gassull M.A. Long-term methotrexate for Crohn's disease: safety and efficacy in clinical practice. Journal of Clinical Gastroenterology 42 (2008) 395-399
34. England M.W., Faust J.B., Wilkerson E.K., and Jacobson K.B. Strontium toxicity in Drosophila melanogaster. Toxicology 65 (1991) 251-257
35. Feng Z., Cronin C.J., Wittig Jr. J.H., Sternberg P.W., and Schafer W.R. An imaging system for standardized quantitative analysis of C. elegans behavior. BMC Bioinformatics 5 (2004) 115
36. Foureman P., Mason J.M., Valencia R., and Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environmental and Molecular Mutagenesis 23 (1994) 208-227
37. Gargano J.W., Martin I., Bhandari P., and Grotewiel M.S. Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Experimental Gerontology 40 (2005) 386-395
38. Gerber B., and Stocker R.F. The Drosophila larva as a model for studying chemosensation and chemosensory learning: a review. Chemical Senses 32 (2007) 65-89
39. Go M.J., Eastman D.S., and Artavanis-Tsakonas S. Cell proliferation control by Notch signaling in Drosophila development. Development (Cambridge, England) 125 (1998) 2031-2040
40. Graf U., Wurgler F.E., Katz A.J., Frei H., Juon H., Hall C.B., and Kale P.G. Somatic mutation and recombination test in Drosophila melanogaster. Environmental Mutagenesis 6 (1984) 153-188
41. Greaves S., Sanson B., White P., and Vincent J.P. A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. Genetics 153 (1999) 1753-1766
42. Greenspan R.J., and Dierick H.A. 'Am not I a fly like thee?' From genes in fruit flies to behavior in humans. Human Molecular Genetics 13 (2004) R267-R273 Spec No 2
43. Gupta S.C., Siddique H.R., Mathur N., Mishra R.K., Mitra K., Saxena D.K., and Chowdhuri D.K. Adverse effect of organophosphate compounds, dichlorvos and chlorpyrifos in the reproductive tissues of transgenic Drosophila melanogaster: 70 kDa heat shock protein as a marker of cellular damage. Toxicology 238 (2007) 1-14
44. Haines N., and van den Heuvel M. A directed mutagenesis screen in Drosophila melanogaster reveals new mutants that influence hedgehog signaling. Genetics 156 (2000) 1777-1785
45. Hallem E.A., and Carlson J.R. The odor coding system of Drosophila. Trends in Genetics 20 (2004) 453-459
46. Harding K.W., Gellon G., McGinnis N., and McGinnis W. A screen for modifiers of deformed function in Drosophila. Genetics 140 (1995) 1339-1352
47. Hartenstein V. Atlas of Drosophila Development, 1st Edition (1993), Cold Spring Harbor Press, New York
48. Hedman J., Seideman P., Albertioni F., and Stenius-Aarniala B. Controlled trial of methotrexate in patients with severe chronic asthma. European Journal of Clinical Pharmacology 49 (1996) 347-349
49. Hirsch H.V., Mercer J., Sambaziotis H., Huber M., Stark D.T., Torno-Morley T., Hollocher K., Ghiradella H., and Ruden D.M. Behavioral effects of chronic exposure to low levels of lead in Drosophila melanogaster. Neurotoxicology 24 (2003) 435-442
50. Hirsch H.V., Possidente D., Averill S., Despain T.P., Buytkins J., Thomas V., Goebel W.P., Shipp-Hilts A., Wilson D., Hollocher K., et al. Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster. Neurotoxicology 30 (2009) 305-311
51. Houle D., Mezey J., Galpern P., and Carter A. Automated measurement of Drosophila wings. BMC Evolutionary Biology 3 (2003) 25
52. Hudson J.B., Podos S.D., Keith K., Simpson S.L., and Ferguson E.L. The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4. Development (Cambridge, England) 125 (1998) 1407-1420
53. Jowett T., Wajidi M.F., Oxtoby E., and Wolf C.R. Mammalian genes expressed in Drosophila: a transgenic model for the study of mechanisms of chemical mutagenesis and metabolism. The EMBO Journal 10 (1991) 1075-1081
54. Kernan M.J. Mechanotransduction and auditory transduction in Drosophila. Pflugers Archiv 454 (2007) 703-720
55. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicology and Applied Pharmacology 172 (2001) 249-261
56. Lai C.Q., Leips J., Zou W., Roberts J.F., Wollenberg K.R., Parnell L.D., Zeng Z.B., Ordovas J.M., and Mackay T.F. Speed-mapping quantitative trait loci using microarrays. Nature Methods 4 (2007) 839-841
57. Lai C.Q., Parnell L.D., Lyman R.F., Ordovas J.M., and Mackay T.F. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Ageing and Development 128 (2007) 237-249
58. Limbourg B., and Zalokar M. Permeabilization of Drosophila eggs. Developmental Biology 35 (1973) 382-387
59. Louis M., Huber T., Benton R., Sakmar T.P., and Vosshall L.B. Bilateral olfactory sensory input enhances chemotaxis behavior. Nature Neuroscience 11 (2008) 187-199
60. Lynch D.W., Schuler R.L., Hood R.D., and Davis D.G. Evaluation of Drosophila for screening developmental toxicants: test results with eighteen chemicals and presentation of a new Drosophila bioassay. Teratogenesis, Carcinogenesis, and Mutagenesis 11 (1991) 147-173
61. Maas Jr. J.W., Vogt S.K., Chan G.C., Pineda V.V., Storm D.R., and Muglia L.J. Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. Journal of Neuroscience 25 (2005) 4118-4126
62. Mackay T.F. The genetic architecture of complex behaviors: lessons from Drosophila, Genetica (2008)
63. Magnusson J., and Ramel C. Genetic variation in the susceptibility to mercury and other metal compounds in Drosophila melanogaster. Teratogenesis, Carcinogenesis, and Mutagenesis 6 (1986) 289-305
64. Marsh J.L., and Thompson L.M. Drosophila in the study of neurodegenerative disease. Neuron 52 (2006) 169-178
65. Mazur P., Cole K.W., and Mahowald A.P. Critical factors affecting the permeabilization of Drosophila embryos by alkanes. Cryobiology 29 (1992) 210-239
66. Meisel R., Bardenheuer W., Strehblow C., Sorg U.R., Elmaagacli A., Seeber S., Flasshove M., and Moritz T. Efficient protection from methotrexate toxicity and selection of transduced human hematopoietic cells following gene transfer of dihydrofolate reductase mutants. Experimental Hematology 31 (2003) 1215-1222
67. Mellerick D.M., and Liu H. Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS. Journal of Neurobiology 60 (2004) 308-318
68. Micchelli C.A., Esler W.P., Kimberly W.T., Jack C., Berezovska O., Kornilova A., Hyman B.T., Perrimon N., and Wolfe M.S. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB Journal 17 (2003) 79-81
69. Moore M.S., DeZazzo J., Luk A.Y., Tully T., Singh C.M., and Heberlein U. Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93 (1998) 997-1007
70. Morgan T.J., and Mackay T.F. Quantitative trait loci for thermotolerance phenotypes in Drosophila melanogaster. Heredity 96 (2006) 232-242
71. Morley E.J., Hirsch H.V., Hollocher K., and Lnenicka G.A. Effects of chronic lead exposure on the neuromuscular junction in Drosophila larvae. Neurotoxicology 24 (2003) 35-41
72. Mukhopadhyay I., Nazir A., Saxena D.K., and Chowdhuri D.K. Heat shock response: hsp70 in environmental monitoring. Journal of Biochemical and Molecular Toxicology 17 (2003) 249-254
73. Muniz Ortiz J.G., Opoka R., Kane D., and Cartwright I.L. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Toxicological Science (2008)
74. Nichols C.D. Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery. Pharmacology & Therapeutics 112 (2006) 677-700
75. NRC, Scientific frontiers in developmental toxicology and risk assessment, in: C.o.D. Toxicology (Ed.), National Academy Press, Washington, D.C., 2000, p. 327.
76. O'Kane C.J. Modelling human diseases in Drosophila and Caenorhabditis. Seminars in cell & Developmental Biology 14 (2003) 3-10
77. Orgogozo V., and Grueber W.B. FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system. BMC Developmental Biology 4 (2005). http://www.normalesup.org/~vorgogoz/FlyPNS/page1.html www.normalesup.org/~vorgogoz/FlyPNS/page1.html
78. Ostensen M., Hartmann H., and Salvesen K. Low dose weekly methotrexate in early pregnancy. A case series and review of the literature. The Journal of Rheumatology 27 (2000) 1872-1875
79. Parr J., Large A., Wang X., Fowler S.C., Ratzlaff K.L., and Ruden D.M. The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor. Journal of Neuroscience Methods 107 (2001) 93-99
80. Price J.V., Savenye E.D., Lum D., and Breitkreutz A. Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics 147 (1997) 1139-1153
81. Rand M.D., Bland C.E., and Bond J. Methylmercury activates enhancer-of-split and bearded complex genes independent of the notch receptor. Toxicological Science 104 (2008) 163-176
82. Rand M.D., Dao J.C., and Clason T.A. Methylmercury disruption of embryonic neural development in Drosophila. Neurotoxicology (2009)
83. Rizki M., Amrani S., Creus A., Xamena N., and Marcos R. Antigenotoxic properties of selenium: studies in the wing spot test in Drosophila. Environmental and Molecular Mutagenesis 37 (2001) 70-75
84. Rizki M., Kossatz E., Velazquez A., Creus A., Farina M., Fortaner S., Sabbioni E., and Marcos R. Metabolism of arsenic in Drosophila melanogaster and the genotoxicity of dimethylarsinic acid in the Drosophila wing spot test. Environmental and Molecular Mutagenesis 47 (2006) 162-168
85. Rubin G.M., and Lewis E.B. A brief history of Drosophila's contributions to genome research. Science (New York, NY) 287 (2000) 2216-2218
86. Sang T.K., and Jackson G.R. Drosophila models of neurodegenerative disease. NeuroRx 2 (2005) 438-446
87. Saraswati S., Fox L.E., Soll D.R., and Wu C.F. Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae. Journal of Neurobiology 58 (2004) 425-441
88. Sawin-McCormack E.P., Sokolowski M.B., and Campos A.R. Characterization and genetic analysis of Drosophila melanogaster photobehavior during larval development. Journal of Neurogenetics 10 (1995) 119-135
89. Schmid A., Chiba A., and Doe C.Q. Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets. Development (Cambridge, England) 126 (1999) 4653-4689
90. Scholz H., Ramond J., Singh C.M., and Heberlein U. Functional ethanol tolerance in Drosophila. Neuron 28 (2000) 261-271
91. Seeger M., Tear G., Ferres-Marco D., and Goodman C.S. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10 (1993) 409-426
92. Siddique H.R., Gupta S.C., Mitra K., Bajpai V.K., Mathur N., Murthy R.C., Saxena D.K., and Chowdhuri D.K. Adverse effect of tannery waste leachates in transgenic Drosophila melanogaster: role of ROS in modulation of Hsp70, oxidative stress and apoptosis. Journal of Applied Toxicology 28 (2008) 734-748
93. Sobels F.H., and Vogel E. Assaying potential carcinogens with Drosophila. Environmental Health Perspectives 15 (1976) 141-146
94. Sokolowski M.B. Drosophila: genetics meets behaviour. Nature Reviews 2 (2001) 879-890
95. Stocker R.F. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell and Tissue Research 275 (1994) 3-26
96. Ting C.Y., and Lee C.H. Visual circuit development in Drosophila. Current Opinion in Neurobiology 17 (2007) 65-72
97. Truman J.W., and Bate M. Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster. Developmental Biology 125 (1988) 145-157
98. Truman J.W., Taylor B.J., and Awad T.A. Formation of the adult nervous system. In: Bate M., and Martinez Arias A. (Eds). Development of Drosophila melanogaster (1993), Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1245-1275
99. Williams D.W., and Truman J.W. Mechanisms of dendritic elaboration of sensory neurons in Drosophila: insights from in vivo time lapse. Journal of Neuroscience 24 (2004) 1541-1550
100. Wilson R.H., Morgan T.J., and Mackay T.F. High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster. Genetics 173 (2006) 1455-1463
101. Wolfgang W.J. Exploring protection from methotrexate-induced teratogenicity in flies. Toxicological Science 99 (2007) 363-365
102. Wong J.M., and Esdaile J.M. Methotrexate in systemic lupus erythematosus. Lupus 14 (2005) 101-105
103. Xu T., and Artavanis-Tsakonas S. deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics 126 (1990) 665-677
104. Yeh E., Gustafson K., and Boulianne G.L. Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 92 (1995) 7036-7040
105. Zappe S., Fish M., Scott M.P., and Solgaard O. Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab on a Chip 6 (2006) 1012-1019