The effects of methotrexate on Drosophila development, female fecundity, and gene expression

Toxicological Sciences

Volumn 89, Issue 2, 2006, Pages 495-503

  Affleck, Joslynn G ^a   Neumann, Katerina ^a   Wong, Lily ^a   Walker, Virginia K ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Dihydrofolate reductase; Drosophila melanogaster; Female fecundity; Gene expression; Methotrexate; Teratogenesis

Indexed keywords

COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID DERIVATIVE; METHOTREXATE;

ANIMAL CELL; ARTICLE; BIOLOGICAL MODEL; CELL CYCLE REGULATION; CELL LINE; CELL METABOLISM; CELL STRUCTURE; CELL TRANSPORT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DNA MICROARRAY; DROSOPHILA MELANOGASTER; EGG; EGG LAYING; ENZYME INHIBITION; EYE MALFORMATION; FEMALE; FEMALE FERTILITY; FEMALE STERILITY; FORELIMB; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; INVERTEBRATE; LARVA; LEG MALFORMATION; LIMB MALFORMATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PHENOTYPE; PROGENY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE; SIGNAL TRANSDUCTION; SURVIVAL; TERATOGENESIS; TUMOR;

ANIMALS; DROSOPHILA MELANOGASTER; FEMALE; FERTILITY; FOLIC ACID ANTAGONISTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; METHOTREXATE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARY; OVIPOSITION; OVUM;

ANIMALIA; DROSOPHILA MELANOGASTER; INVERTEBRATA;

EID: 31144464487     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj036     Document Type: Article

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