An imaging system for standardized quantitative analysis of C. elegans behavior

BMC Bioinformatics

Volumn 5, Issue , 2004, Pages

  Feng, Zhaoyang ^a   Cronin, Christopher J ^b   Wittig Jr , John H ^a   Sternberg, Paul W ^b   Schafer, William R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATED ANALYSIS; BEHAVIORAL DATA; CAENORHABDITIS ELEGANS; GENETIC ANALYSIS; HARDWARE CONFIGURATIONS; HIGH-THROUGHPUT; PHENOTYPIC ANALYSIS; PHENOTYPIC DATA;

CYTOLOGY; TOOLS;

IMAGING SYSTEMS;

ANALYTIC METHOD; ANIMAL BEHAVIOR; ARTICLE; ASSAY; AUTOANALYSIS; BEHAVIOR DISORDER; CAENORHABDITIS ELEGANS; COMPARATIVE STUDY; COMPUTER PROGRAM; COMPUTER SYSTEM; CONTROLLED STUDY; GENETIC DATABASE; GENETIC PARAMETERS; IMAGING SYSTEM; INFORMATION PROCESSING; INTERNET; LABORATORY TEST; MORPHOLOGY; NEMATODE; NEUROBIOLOGY; NONHUMAN; PHENOTYPE; QUANTITATIVE ANALYSIS; RELIABILITY; SCORING SYSTEM; STANDARDIZATION; TIME; ANIMAL; DEVICES; GENETICS; MOTOR ACTIVITY; MULTIMEDIA; MUTATION; PHYSIOLOGY; PROCEDURES; VIDEO MICROSCOPY;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

ANIMALS; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; MICROSCOPY, VIDEO; MOTOR ACTIVITY; MULTIMEDIA; MUTATION; PHENOTYPE; SOFTWARE;

EID: 13244292289     PISSN: 14712105     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2105-5-115     Document Type: Article

References (11)

1. Rankin CH: From gene to identified neuron to behaviour in Caenorhabditis elegans. Nat Rev Genet 2002, 3: 22-630.
2. Sawin ER, Ranganathan R, Horvitz HR: C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 2000, 26:619-631.
3. Brockie PJ, Mellem JE, Hills T, Madsen DM, Maricq AV: The C. elegans glutamate receptor subunit NMR-1 Is required for slow NMDA-Activated currents that regulate reversal frequency during locomotion. Neuron 2001, 31:617-630.
4. Hardaker LA, Singer E, Kerr R, Zhou GT, Schafer WR: Serotonin modulates locomotory behavior and coordinates egg-laying and movement in Caenorhabditis elegans. J Neurobiol 2001, 49:303-313.
5. Brenner S: The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
6. Hodgkin J: Male phenotypes and mating efficiency in Caenorhabditis elegans. Genetics 1983, 103:43-64.
7. Waggoner L, Zhou GT, Schafer RW, Schafer WR: Control of behavioral states by serotonin in Caenorhabditis elegans. Neuron 1998, 21:203-214.
8. Pierce-Shimomura JT, Morse TM, Lockery SR: The fundamental role of pirouettes in Caenorhabditis elegans chemotaxis. J Neurosci 1999, 19:9557-9569.
9. Geng W, Cosman P, Berry CC, Feng Z, Schafer WR: Automatic tracking, feature extraction and classification of C. elegans phenotypes. IEEE Trans Biomed Eng 2004 in press.
10. Sanyal S, Wintle RF, Kindt KS, Nuttley WM, Arvan R, Fitzmaurice P, Bigras E, Merz D, Hebert TE, van der Kooy D, Schafer WR, Culotti JG, van Tol HHM: Dopamine modulates the plasticity of mechanosensory responses in C. elegans. EMBO Journal 2004, 23:473-482.
11. Geng W, Cosman P, Baek JH, Berry CC, Schafer WR: Quantitative classification and natural clustering of C. elegans behavioral phenotypes. Genetics 2003, 165:1117-1123.