Isolation, structure and biological activities of platensimycin B 4 from Streptomyces platensis

Journal of Antibiotics

Volumn 62, Issue 12, 2009, Pages 699-702

  Zhang, Chaowei ^a   Ondeyka, John ^a   Guan, Ziqiang ^a   Dietrich, Lisa ^a   Burgess, Bruce ^a   Wang, Jun ^a,b   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Building 8   (China)

Author keywords

Antibiotic; FabF inhibitor; FAS II inhibitor; Fatty acid synthesis inhibitor; Platensimycin B4; Streptomyces platensis

Indexed keywords

ANTIINFECTIVE AGENT; AROMATIC COMPOUND; BACTERIAL ENZYME; CARBOXYL GROUP; FABF ENZYME; FATTY ACID SYNTHASE INHIBITOR; GLUCOSIDE; PHENOL DERIVATIVE; PLATENSIMYCIN B4; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FATTY ACID SYNTHESIS; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES PLATENSIS; STREPTOMYCETACEAE;

ADAMANTANE; AMINOBENZOIC ACIDS; ANILIDES; BACTERIAL PROTEINS; ENZYME INHIBITORS; FATTY ACIDS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STREPTOMYCES PLATENSIS;

EID: 73649103728     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.106     Document Type: Article

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