Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

European Journal of Pharmacology

Volumn 628, Issue 1-3, 2010, Pages 155-163

  Hu, Lingai ^a   Sun, Yukun ^b   Hu, Jian ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Jining Stomatology Hospital   (China)

Author keywords

Apoptosis; Catalpol; HUVEC; Hydrogen peroxide

Indexed keywords

CASPASE 3; CATALPOL; HYDROGEN PEROXIDE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; QUATERNARY AMMONIUM COMPOUNDS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 73649093725     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.046     Document Type: Article

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