Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transporters

PLoS Computational Biology

Volumn 5, Issue 10, 2009, Pages

  Jeon, Jouhyun ^a   Yang, Jae Seong ^a   Kim, Sanguk ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; COOPERATIVE COMMUNICATION; SUBSTRATES;

CO-EVOLUTIONARY; CONFORMATIONAL CHANGE; FUNCTIONAL RESIDUES; LONG-RANGE COMMUNICATIONS; MAJOR FACILITATOR SUPERFAMILY; MEMBRANE PROTEINS; MOLECULAR MECHANISM; SEQUENCE CONSERVATION; SUBSTRATE-BINDING SITES; TWO-STATE;

PROTEINS;

CARRIER PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; EMRD PROTEIN; GLPT PROTEIN; LACY PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; VALIDATION STUDY; CHEMISTRY; GENETICS; METHODOLOGY; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 73549113828     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000522     Document Type: Article

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