Importance of sulfonylimidazolidinone motif of 4-phenyl-1- arylsulfonylimidazolidinones for their cytotoxicity: Synthesis of 2-benzoyl-4-phenyl[1,2,5]thiazolidine-1,1-dioxides and their cytotoxcity

Archives of Pharmacal Research

Volumn 26, Issue 1, 2003, Pages 9-14

  Kim, Il Whan ^a   Lee, Chong Kyo ^b   Kim, Hae Soo ^b   Jung, Sang Hun ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

(Benzenesulfonyl) 4 phenyl 1 imidazolidinones; 2 (benzoyl) 4 phenyl 1,2,5 thiadiazolidine 1,1 dioxides; Cytotoxicity

Indexed keywords

IMIDAZOLE; IMIDAZOLE DERIVATIVE;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; HUMAN; SYNTHESIS;

ANIMALS; HUMANS; IMIDAZOLES; TUMOR CELLS, CULTURED;

EID: 0042810778     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF03179923     Document Type: Article

References (12)

1. Everitt, E., Wohlfart, C., Spectrometric quantitation of anchorage-dependent cell numbers extraction of naphthol blue-blackstained cellular protein. Anal. Biochem., 162, 122-129 (1987).
2. Howbert, J. J., Grossman, C. S., Crowell, T. A., Rieder, B. J., Harper, R. W., Kramer, K. E., Tao, E. V., Aikins, J., Poore, G. A., Rinzel, S. M., Grindey, G. B., Shaw, W. N., Todd, G. C., Novel Agents Effective against Solid Tumors: The Diarylsulfonylureas. Synthesis, Activities, and Analysis of Quantitative Structure-Activity Relationships. J. Med. Chem., 33, 2393-2407 (1990).
3. Hwang, H.-S., Moon, E.-Y., Seong, S.-K., Choi, C.-H., Chung, C.-H., Jung, S.-H., Yoon, S.-J., Characterization of the anticancer activity of DW2282, a new anticancer agent. Anticancer Res., 1999, 19, 5087-5093.
4. Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxicity of novel arylsulfony-limidazolidinones containing sulfonylurea pharmacophore. Arch. Pharm. Res., 19, 570-580 (1996).
5. Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxic activity of novel arylsulfonylimidazolidinones. Bioorg. & Med. Chem. Letters, 6, 2553-2558 (1996).
6. Jung, S.-H., Kwak, S.-J., Planar structural requirement at 4-position of 1-arylsulfonyl-4-phenyl-4,5-dihydro-2-imidazolones for their cytotoxicity. Arch. Pharm. Res., 20, 283-287 (1997).
7. Jung, S.-H., Lee, H.-S., Song, J.-S., Kim, H.-M., Han, S.-B., Lee, C.-W., Lee, M., Choi, D.-R., Lee, J.-A., Chung, Y.-H., Yoon, S.-J., Moon, E.-Y., Hwang, H.-S., Seong, S.-K., Lee, D.-K., Synthesis and antitumor activity of 4-phenyl-1-arylsulfonylimidazolidinones. Bioorg. & Med. Chem. Letters, 8, 2553-2558 (1997).
8. Jung, S.-H., Kwak, S.-J., Kim, N.-D., Lee, S.-U., Lee, C.-O., Stereochemical Requirement at 4-Position of 4-Phenyl-1- arylsulfonylimidazolidinones for their Cytotoxicities. Arch. Pharm. Res., 23, 35-41 (2000).
9. Lee, H.-S., Park, K.-L., Choi, S.-H, Lee C.-O., and Jung, S.-H., Effect of substituents on Benzenesulfonyl Motif of 4-phenyl-1- arylsulfonylimidazolidinones for their cytotoxicity. Arch. Pharm. Res., 23, 579-584 (2000).
10. Park, K.-L., Moon, B.-G., Jung, S.-H., Kim, J.-G., Suh, I.-H., Multicenter Hydrogen Bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt. Acta Crystallography, C56,1247-1250 (2000).
11. Perrin, D. D., Armarego, W. L. F., and Perrin, D. R., Purification of laboratory chemicals, 2nd edition. Pergamon Press, Oxford, England, (1982).
12. Skehan, P., Storeng, R., Scudiero, D. A., Monks, A., MacMahon, J., Vista, D. T., Kenny, S., Boyd, M. R. New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990).