Synthesis of conformationally constrained analogues of linezolid: Structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones

Journal of Medicinal Chemistry

Volumn 45, Issue 18, 2002, Pages 3953-3962

  Selvakumar, Natesan ^a   Srinivas, Deekonda ^a   Khera, Manoj Kumar ^a   Kumar, Magadi Sitaram ^a   Mamidi, Rao N V S ^a   Sarnaik, Hemanth ^a   Charavaryamath, Chandrashekar ^a   Rao, Bonthu Srinivasa ^a   Raheem, Mohammed A ^a   Das, Jagattaran ^a   Iqbal, Javed ^a   Rajagopalan, Ramanujam ^a  

^a DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

LINEZOLID; OXAZOLIDINONE DERIVATIVE; THIOAMIDE; THIOCARBAMIC ACID DERIVATIVE; THIOUREA DERIVATIVE; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANTI-BACTERIAL AGENTS; BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; OXAZOLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN RESISTANCE;

EID: 0037194635     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020092y     Document Type: Article

References (25)

1. Antibiotics that resist resistance
2. Hospital-acquired infections: Diseases with increasingly limited therapies
3. Multiple-antibiotic-resistant pathogenic bacteria
4. The challenge ofmethicillin-resistant staphylococcus aureus
5. Multidrug-resistant enterococcus faecium: An untreatable nosocomial pathogen
6. Methicillin-resistant staphylococcus aureus clinical strain with reduced vancomycin susceptibility
7. A new resistance in resistant staphylococcus aureus
8. Drug firms restock antibacterial arsenal
9. Oxazolidinone antibacterial agents
10. The oxazolidinone eperozolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin
11. Mechanism of action of oxazolidinones: Effects of linezolid and eperozolid on translation reactions
12. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria
13. Synthesis and antibacterial of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections
14. The pharmacologic and bacteriologic properties of oxazolidinones, a new class of synthetic antimicrobials
15. Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The "B" Group
16. Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The "A" Group
17. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
18. Synthesis and antimicrobial activity of oxazolidin-2-ones and related heterocycles
19. Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 3. Synthesis and evaluation of 5-thiocarbamate oxazolidinones
20. Reduction d'azides en amines primaires par une methode generale utilisant la reaction de staudinger
21. Synthesis of (-)- and (+)-2-hydroxy-6-keto-N-methylmorphinans, their O-methyl ethers, and 2-deoxycongeners
22. Thionation reactions of lawesson's reagents
23. Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 1. Conversion of 5-substituent on oxazolidinone
24. Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2. Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl oxazolidinones
25. Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically