Polycyclic aromatic compounds as anticancer agents: Synthesis and biological evaluation of some chrysene derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2877-2880

  Becker, Frederick F ^a   Banik, Bimal K ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHRYSENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CHRYSENES; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; TUMOR CELLS, CULTURED;

EID: 0032553002     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00520-4     Document Type: Article

References (13)

1. 1. For a general review see: Freudenthal, R.; Jones, P. W. Carcinogenesis-a comprehensive survey; Raven Press: New York, 1976; vol. 1-3.
2. 2. For a recent example see: Harvey, R. G. Polycyclic aromatic hydrocarbons; Wiley-VCH, 1997.
3. 3. Di Raddo, P.; Chan, T. H. J. Org. Chem. 1982, 47, 1427 and references cited therein.
4. 4. For some recent examples: ( a ) Cherubim, P.; Deady, L. W.; Dorkos, M.; Quazi, N. H.; Baguley, B. C.; Denny, W. A. Anti-cancer drug design. 1993, 8, 429.
5. ( b ) Palmer, B. D.; Lee, H. H.; Baguley, B. C.; Denny, W. A. J. Med. Chem. 1992, 35, 258.
6. 5. Wingard, L. B.; Tritton, T. R. Cancer Res. 1985, 45, 3529.
7. 6. For an example, see: Jorgensen, K.; Ipsen, J. H. Biochem. Biophys. Acta. 1991, 1062, 227 and references cited therein.
8. 7. Bair, K. W.; Tuttle, R. L.; Knick, V. C.; Cory, M.; McKee, D. D. J. Med. Chem. 1990, 33, 2385.
9. 8. Banik, B. K.; Mukhopadhyay, C.; Venkatraman, M. S.; Becker, F. F. Tetrahedron Lett. 1998, in press.
10. 9. Lee, M.; Lown, J. W. J. Org. Chem. 1987, 52, 5717.
11. 10. Holzapfel, C. W.; Pettit, G. R. J. Org. Chem. 1985, 50, 2323.
12. 11. Details will be published elsewhere.
13. 2: C, 84.8%; H, 7.9%; N, 7.3%. Found: C 84.48%; H, 7.60%; N, 7.30%.