8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 782-789

  Ivachtchenko, Alexandre V ^a,b   Mitkin, Oleg D ^a   Tkachenko, Sergey E ^b   Okun, Ilya M ^a,b   Kysil, Volodymyr M ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

5 HT6 receptor; Antagonist; Dimebolin; Dimebon; Pyrido 3,4 b indole; Serotonin receptors

Indexed keywords

2 BENZYL N (3 FLUOROPHENYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE 8 SULFONAMIDE; 2 METHYL 5 [(4 METHYLPHENYL)SULFONYL] 8 (PHENYLSULFONYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2 METHYL 8 (PHENYLSULFONYL) 5 (2 PYRIDIN 2 YLETHYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2 METHYL 8 (PYRIDIN 3 YLSULFONYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2 METHYL 8 (PYRIDIN 4 YLSULFONYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2 METHYL 8 [(4 METHYLPIPERAZIN 1 YL)SULFONYL] 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; 2,5 DIMETHYL 8 (METHYLSULFONYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 2,5 DIMETHYL 8 (PHENYLSULFONYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE HYDROCHLORIDE; 8 (PHENYLSULFONYL) 2 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; 8 [(3 FLUOROPHENYL)SULFONYL] 2 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; DIMEBON; INDOLE DERIVATIVE; N )3 FLUOROPHENYL) 2 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE 8 SULFONAMIDE HYDROCHLORIDE; N,N,2 TRIMETHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE 8 SULFONAMIDE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; IC 50; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CELL LINE; HUMANS; INDOLES; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONAMIDES; SULFONES;

EID: 73449149267     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.035     Document Type: Article

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