Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3183-3187

  Ivachtchenko, Alexandre V ^a,b   Frolov, Eugene B ^b   Mitkin, Oleg D ^b   Kysil, Volodymyr M ^b   Khvat, Alexander V ^b   Okun, Ilya M ^a,b   Tkachenko, Sergey E ^a,b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

Carbolines; Analogues; Antagonists; Dimebon; Histamine H1; Serotonin 5 HT6

Indexed keywords

DIMEBON; GAMMA CARBOLINE DERIVATIVE; HISTAMINE H1 RECEPTOR ANTAGONIST; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

CARBOLINES; CELL LINE; HISTAMINE H1 ANTAGONISTS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; RECEPTORS, HISTAMINE H1; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65749088098     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.128     Document Type: Article

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