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Volumn 30, Issue 5, 2005, Pages 479-495

Drug discovery targets: 5-HT6 receptor

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; AMPEROZIDE; ARIPIPRAZOLE; BVT 5182; DONEPEZIL; HALOPERIDOL; JCF 177; LY 483518; MESORIDAZINE; MOLINDONE; QUETIAPINE; RISPERIDONE; RO 046790; RO 4368554; RO 630563; RO 657199; RO 657674; RO 660074; SB 214111; SB 258510; SB 331711; SB 357134; SB 399885; SEROTONIN 6 ANTAGONIST; SEROTONIN ANTAGONIST; SGS 518; TIOTIXENE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 22244452968     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2005.030.05.907630     Document Type: Review
Times cited : (42)

References (69)
  • 1
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their function
    • Barnes, N.M., Sharp, T. A review of central 5-HT receptors and their function. Neuropharmacology 1999, 38(8): 1083-152.
    • (1999) Neuropharmacology , vol.38 , Issue.8 , pp. 1083-1152
    • Barnes, N.M.1    Sharp, T.2
  • 2
    • 0036657210 scopus 로고    scopus 로고
    • Biological mechanisms, cerebrovascular alterations and pharmacological targets in the pathology of dementia
    • Albensi, B.C. Biological mechanisms, cerebrovascular alterations and pharmacological targets in the pathology of dementia. Drug News Perspect 2002, 15(6): 333-7.
    • (2002) Drug News Perspect , vol.15 , Issue.6 , pp. 333-337
    • Albensi, B.C.1
  • 4
    • 0033860704 scopus 로고    scopus 로고
    • Alzheimer's disease: What is it, how many people have it, and why do we need to know?
    • Albert M.S., Drachman, D.A. Alzheimer's disease: What is it, how many people have it, and why do we need to know? Neurology 2000, 55(2): 166-8.
    • (2000) Neurology , vol.55 , Issue.2 , pp. 166-168
    • Albert, M.S.1    Drachman, D.A.2
  • 6
    • 0037177552 scopus 로고    scopus 로고
    • Schizophrenia: Diverse approaches to a complex disease
    • Sawa, A., Snyder, S.H. Schizophrenia: Diverse approaches to a complex disease. Science 2002, 296(5568): 692-5.
    • (2002) Science , vol.296 , Issue.5568 , pp. 692-695
    • Sawa, A.1    Snyder, S.H.2
  • 7
    • 0142244688 scopus 로고    scopus 로고
    • Schizophrenia
    • Freedman, R. Schizophrenia. New Engl J Med 2003, 349(18): 1738-49.
    • (2003) New Engl J Med , vol.349 , Issue.18 , pp. 1738-1749
    • Freedman, R.1
  • 8
    • 0037209930 scopus 로고    scopus 로고
    • An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia
    • Buchanan, R.W., Summerfelt, A., Tek, C., Gold, J. An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. Schizophr Res 2003, 59(1): 29-33.
    • (2003) Schizophr Res , vol.59 , Issue.1 , pp. 29-33
    • Buchanan, R.W.1    Summerfelt, A.2    Tek, C.3    Gold, J.4
  • 10
    • 3142704173 scopus 로고    scopus 로고
    • Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders
    • Roth, B.L., Hanizavarch, S.M., Blum, A.E. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology (Berlin) 2004, 174(1): 17-24.
    • (2004) Psychopharmacology (Berlin) , vol.174 , Issue.1 , pp. 17-24
    • Roth, B.L.1    Hanizavarch, S.M.2    Blum, A.E.3
  • 11
    • 0032716595 scopus 로고    scopus 로고
    • 5-HT system and cognition
    • Meneses, A. 5-HT system and cognition. Neurosci Biobehav Rev 1999, 23(8): 1111-25.
    • (1999) Neurosci Biobehav Rev , vol.23 , Issue.8 , pp. 1111-1125
    • Meneses, A.1
  • 17
    • 0036382166 scopus 로고    scopus 로고
    • 7 serotonin receptors
    • 7 serotonin receptors. Pol J Pharmacol 2002, 54(4): 327-41.
    • (2002) Pol J Pharmacol , vol.54 , Issue.4 , pp. 327-341
    • Wesolowska, A.1
  • 18
    • 0347824360 scopus 로고    scopus 로고
    • Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling
    • Hirst, W.D., Abrahamsen, B., Blaney, F.E., Calver, A.R., Aloj, L., Price, G.W., Medhurst, A.D. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol 2003, 64: 1295-308.
    • (2003) Mol Pharmacol , vol.64 , pp. 1295-1308
    • Hirst, W.D.1    Abrahamsen, B.2    Blaney, F.E.3    Calver, A.R.4    Aloj, L.5    Price, G.W.6    Medhurst, A.D.7
  • 21
    • 22244461410 scopus 로고    scopus 로고
    • Updated May 20
    • Prous Science Drug R&D Backgrounders: Obesity (online publication). Updated May 20, 2005.
    • (2005) Obesity (Online Publication)
  • 22
    • 0035338157 scopus 로고    scopus 로고
    • Pharmacotherapy of obesity: Targets and perspectives
    • Chiesi, M., Huppertz, C., Hofbauer, K.G. Pharmacotherapy of obesity: Targets and perspectives. Trends Pharmacol Sci 2001, 22(5): 247-54.
    • (2001) Trends Pharmacol Sci , vol.22 , Issue.5 , pp. 247-254
    • Chiesi, M.1    Huppertz, C.2    Hofbauer, K.G.3
  • 23
    • 0032577350 scopus 로고    scopus 로고
    • Strategies and potential molecular targets for obesity treatment
    • Campfield, L.A., Smith, F.J., Burn, P. Strategies and potential molecular targets for obesity treatment. Science 1998, 280(5368): 1383-7.
    • (1998) Science , vol.280 , Issue.5368 , pp. 1383-1387
    • Campfield, L.A.1    Smith, F.J.2    Burn, P.3
  • 24
    • 22244476288 scopus 로고    scopus 로고
    • New drug development prospects for obesity
    • Sorbera, L.A. New drug development prospects for obesity. Environner 2004, 1(1): 34.
    • (2004) Environner , vol.1 , Issue.1 , pp. 34
    • Sorbera, L.A.1
  • 25
    • 0002354695 scopus 로고    scopus 로고
    • 6 antisense oligonucleotide i.c.v. affects rat performance in the water maze and feeding behavior
    • 6 antisense oligonucleotide i.c.v. affects rat performance in the water maze and feeding behavior. J Psychopharmacol 1997, 11: A64.
    • (1997) J Psychopharmacol , vol.11
    • Bentley, J.C.1
  • 26
    • 22244475310 scopus 로고    scopus 로고
    • 6 receptor antagonism: A novel mechanism for the management of diabetes
    • (Feb 17-18, London)
    • 6 receptor antagonism: A novel mechanism for the management of diabetes. SMi Conf Obesity and Related Disorders (Feb 17-18, London) 2003.
    • (2003) SMi Conf Obesity and Related Disorders
    • Caldirola, P.1
  • 27
    • 0031748656 scopus 로고    scopus 로고
    • Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptors
    • Sleight, A.J., Boess, F.G., Bos, M., Levet-Trafit, B., Riemer, C., Bourson, A. Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol 1998, 124(3): 556-62.
    • (1998) Br J Pharmacol , vol.124 , Issue.3 , pp. 556-562
    • Sleight, A.J.1    Boess, F.G.2    Bos, M.3    Levet-Trafit, B.4    Riemer, C.5    Bourson, A.6
  • 28
    • 22244438134 scopus 로고    scopus 로고
    • Ro-65-7674
    • Ro-65-7674: Drug Data Rep 1999, 21(10): 871.
    • (1999) Drug Data Rep , vol.21 , Issue.10 , pp. 871
  • 39
    • 22244474527 scopus 로고    scopus 로고
    • Effects of antipsychotic drugs on acetylcholine efflux in the hippocampus of the rat
    • Abst P-174.
    • Kennedy, J.S., Southall, S.S., Rodriguez, D., Nomikos, G.G. Effects of antipsychotic drugs on acetylcholine efflux in the hippocampus of the rat. Int Psychogeriatr 2001, 13(Suppl. 2): Abst P-174.
    • (2001) Int Psychogeriatr , vol.13 , Issue.SUPPL. 2
    • Kennedy, J.S.1    Southall, S.S.2    Rodriguez, D.3    Nomikos, G.G.4
  • 40
    • 0034098959 scopus 로고    scopus 로고
    • 6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate
    • 6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. Br J Pharmacol 2000, 130(1): 23-6.
    • (2000) Br J Pharmacol , vol.130 , Issue.1 , pp. 23-26
    • Dawson, L.A.1    Nguyen, H.W.2    Li, P.3
  • 41
    • 0034782825 scopus 로고    scopus 로고
    • 6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    • 6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 2001, 25(5): 662-8.
    • (2001) Neuropsychopharmacology , vol.25 , Issue.5 , pp. 662-668
    • Dawson, L.A.1    Nguyen, H.W.2    Li, P.3
  • 42
    • 0346250850 scopus 로고    scopus 로고
    • 6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex
    • 6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex. Synapse 2004, 51(2): 158-64.
    • (2004) Synapse , vol.51 , Issue.2 , pp. 158-164
    • Lacroix, L.P.1    Dawson, L.A.2    Hagan, J.J.3    Heidbreder, C.A.4
  • 47
    • 0034740154 scopus 로고    scopus 로고
    • 6 receptor antagonists enhance retention of a water maze task in the rat
    • 6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology (Berlin) 2001, 158(2): 114-9.
    • (2001) Psychopharmacology (Berlin) , vol.158 , Issue.2 , pp. 114-119
    • Rogers, D.C.1    Hagan, J.J.2
  • 49
    • 3042561627 scopus 로고    scopus 로고
    • 6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation - An effect sensitive to NMDA receptor antagonism
    • 6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation - An effect sensitive to NMDA receptor antagonism. Neuropharmacology 2004, 47(2): 195-204.
    • (2004) Neuropharmacology , vol.47 , Issue.2 , pp. 195-204
    • King, M.V.1    Sleight, A.J.2    Woolley, M.L.3    Topham, I.A.4    Marsden, C.A.5    Fone, K.C.F.6
  • 53
    • 0348124388 scopus 로고    scopus 로고
    • 6 antagonist, Ro 04-6790 on food consumption in rats trained to a fixed feeding regime
    • 6 antagonist, Ro 04-6790 on food consumption in rats trained to a fixed feeding regime. Br J Pharmacol 1999, 126: 66P.
    • (1999) Br J Pharmacol , vol.126
    • Bentley, J.C.1
  • 54
    • 22244462620 scopus 로고    scopus 로고
    • 6 receptor antagonist BVT.5182 reduces body weight of high fat diet-induced mice
    • Abst T1:P1-094
    • 6 receptor antagonist BVT.5182 reduces body weight of high fat diet-induced mice. Int J Obes 2003, 27(Suppl. 1): Abst T1:P1-094.
    • (2003) Int J Obes , vol.27 , Issue.SUPPL. 1
    • Svartengren, J.1    Ohman, B.2    Edling, N.3
  • 58
    • 0035246514 scopus 로고    scopus 로고
    • 6 receptor antagonists: Lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
    • 6 receptor antagonists: Lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides. Eur J Med Chem 2001, 36(2): 165-78.
    • (2001) Eur J Med Chem , vol.36 , Issue.2 , pp. 165-178
    • Boes, M.1    Sleight, A.J.2    Godel, T.3    Martin, J.R.4    Reimer, C.5    Stadler, H.6
  • 68
    • 0036199878 scopus 로고    scopus 로고
    • Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    • Subramanian, N., Kalkman, H.O. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Prog Neuro-Psychopharmacol Biol Psychiatr 2002, 26(3): 553.
    • (2002) Prog Neuro-Psychopharmacol Biol Psychiatr , vol.26 , Issue.3 , pp. 553
    • Subramanian, N.1    Kalkman, H.O.2
  • 69
    • 0035673012 scopus 로고    scopus 로고
    • Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders
    • Kalkman, H.O., Subramanian, N., Hoyer, D. Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 2001, 25(6): 904-14.
    • (2001) Neuropsychopharmacology , vol.25 , Issue.6 , pp. 904-914
    • Kalkman, H.O.1    Subramanian, N.2    Hoyer, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.