Protective effects of β-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

Genetics and Molecular Research

Volumn 8, Issue 4, 2009, Pages 1367-1375

  Dias, C D ^a   Araujo B C ^b   Dutra, E S ^a   Nepomuceno, J C ^a,b  

^a Universidade Federal de Uberlßndia   (Brazil)

^b Laboratory for Cytogenetics and Mutagenesis   (Brazil)

Author keywords

carotene; Antigenotoxicity; Antioxidants; Doxorubicin; Drosophila melanogaster; SMART

Indexed keywords

BETA CAROTENE; DOXOLEM; DOXORUBICIN; PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG EFFECT; EMBRYO; FEMALE; GENETIC RECOMBINATION; GENOTOXICITY; MALE; MUTANT; NONHUMAN; SOMATIC CELL; SOMATIC MUTATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA CAROTENE; DOXORUBICIN; DROSOPHILA MELANOGASTER; FEMALE; MUTAGENS;

DROSOPHILA MELANOGASTER;

EID: 73449111275     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/vol8-4gmr626     Document Type: Article

References (43)

1. Abraham SK (1994). Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination. Mutagenesis 9: 383-386.
2. Ames BN, Shigenaga MK and Hagen TM (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U. S. A. 90: 7915-7922.
3. Bast A and Haenen GRMM (2002). The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 11: 251-258.
4. Benchekroun MN, Sinha BK and Robert J (1993). Doxorubicin-induced oxygen free radical formation in sensitive and doxorubicin-resistant variants of rat glioblastoma cell lines [corrected and republished erratum originally printed in FEBS Lett. 1993 May 17;322 (3): 295-8]. FEBS Lett. 326: 302-305.
5. Burri BJ (1997). β-carotene and human health: a review of current research. Nutr. Res. 17: 547-580.
6. Costa WF and Nepomuceno JC (2006). Protective effects of a mixture of antioxidant vitamins and minerals on the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Environ. Mol. Mutagen. 47: 18-24.
7. Cui Y, Lu Z, Bai L, Shi Z, et al. (2007). b-carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur. J. Cancer 43: 2590-2601.
8. De Flora S, Bagnasco M and Vainio H (1999). Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues. Mutagenesis 14: 153-172.
9. Dhawan A, Kayani MA, Parry JM, Parry E, et al. (2003). Aneugenic and clastogenic effects of doxorubicin in human lymphocytes. Mutagenesis 18: 487-490.
10. Dutra ES, Dias CD, Araújo BC, Castro AJS, et al. (2009). Effect of organic tomato (Lycopersicon esculentum) extract on the genotoxicity of doxorubicin in the Drosophila wing spot test. Genet. Mol. Biol. 32: 133-137.
11. Fragiorge EJ, Spanó MA and Antunes LMG (2007). Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Biol. 30: 449-455.
12. Frei H and Würgler FE (1988). Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203: 297-308.
13. Frei H and Würgler FE (1995). Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334: 247-258.
14. Gandini S, Merzenich H, Robertson C and Boyle P (2000). Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur. J. Cancer 36: 636-646.
15. George B, Kaur C, Khurdiya DS and Kapoor HC (2004). Antioxidants in tomato (Lycopersium esculentum) as a function of genotype. Food Chem. 84: 45-51.
16. Gradelet S, Astorg P, Le Bon AM, Berges R, et al. (1997). Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers. Cancer Lett. 114: 221-223.
17. Graf U, Wurgler FE, Katz AJ, Frei H, et al. (1984). Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6: 153-188.
18. Gülkaç MD, Akpinar G, Ustun H and Ozon KA (2004). Effects of vitamin A on doxorubicin-induced chromosomal aberrations in bone marrow cells of rats. Mutagenesis 19: 231-236.
19. Guruvayoorappan C and Kuttan G (2007). β-carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in B16F-10 melanoma cells. Nutr. Res. 27: 336-342.
20. Guzmán-Rincón J and Graf U (1995). Drosophila melanogaster Somatic Mutation and Recombination Test as a Biomonitor. In: Biomonitors and Biomarkers as Indicators of Enviromental Change (Butterworth FM, Corkun LD and Guzmán-Rincón J, eds.). Plenum Press, New York, 169-181.
21. He Y, Root MM, Parker RS and Campbell TC (1997). Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status. Nutr. Cancer 27: 238-244.
22. Islaih M, Halstead BW, Kadura IA, Li B, et al. (2005). Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals. Mutat. Res. 578: 100-116.
23. Kada T, Inoue T and Namiki M (1982). Environmental Desmutagens and Antimutagens. In: Environmental Mutagenesis, Carcinogenesis and Plant Biology (Klekowski EJ Jr, ed.). Praeger, New York, 133-152.
24. Keizer HG, Pinedo HM, Schuurhuis GJ and Joenje H (1990). Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol. Ther. 47: 219-231.
25. Konopacka M and Rzeszowska-Wolny J (2001). Antioxidant vitamins C, E and β-carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes in vitro. Mutat. Res. 491: 1-7.
26. Konopacka M, Widel M and Rzeszowska-Wolny J (1998). Modifying effect of vitamins C, E and β-carotene against gamma-ray-induced DNA damage in mouse cells. Mutat. Res. 417: 85-94.
27. Krinsky NI (1991). Effects of carotenoids in cellular and animal systems. Am. J. Clin. Nutr. 53: 238S-246S.
28. Lehmann M, Franco A, de Souza Prudente V, Lukza RM, et al. (2003). Doxorubicin and two of its analogues are preferential inducers of homologous recombination compared with mutational events in somatic cells of Drosophila melanogaster. Mutat. Res. 539: 167-175.
29. Menegola E, Broccia ML and Renzo FD (2001). Teratogenic effects of doxorubicin in rats at midgestation and at term. Teratog. Carcinog. Mutagen. 21: 283-293.
30. Moreno FS, Wu TS, Penteado MV, Rizzi MB, et al. (1995). A comparison of β-carotene and vitamin A effects on a hepatocarcinogenesis model. Int. J. Vitam. Nutr. Res. 65: 87-94.
31. Oliveira GS, Figueiredo ASP, Santos RS and Vianna LM (2007). Effect of β-carotene supplementation on the blood pressure of rats. [Efeito da suplementação de beta-caroteno na pressão arterial de ratos]. Rev. Nutr. 20: 39-45.
32. Peto R, Doll R, Buckley JD and Sporn MB (1981). Can dietary β-carotene materially reduce human cancer rates? Nature 290: 201-208.
33. Picada JN, Kern AL, Ramos LLP and Saffi J (2003). O Extresse Oxidativo e as Defesas Antioxidantes. In: Genética Toxicológica (Silva J, Erdtmann B and Henriques JAP, eds.). Alcance, Porto Alegre, 251-268.
34. Quiles JL, Huertas JR, Battino M, Mataix J, et al. (2002). Antioxidant nutrients and adriamycin toxicity. Toxicology 180: 79-95.
35. Ramji S, Lee C, Inaba T, Patterson AV, et al. (2003). Human NADPH-cytochrome p450 reductase over expression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines. Cancer Res. 63: 6914-6919.
36. Riboli E and Norat T (2003). Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr. 78: 559S-569S.
37. Rodriguez-Arnaiz R, Sortibran AC and Tellez GO (2004). Detection of mitotic recombination and sex chromosome loss induced by adriamycin, chlorambucil, demecolcine, paclitaxel and vinblastine in somatic cells of Drosophila melanogaster in vivo. Mutagenesis 19: 121-127.
38. Salvadori DM, Ribeiro LR, Oliveira MD, Pereira CA, et al. (1992). β-carotene as a modulator of chromosomal aberrations induced in mouse bone marrow cells. Environ. Mol. Mutagen. 20: 206-210.
39. Santos HS and Cruz WMS (2001). The antioxidant vitamin nutritional therapy and the chemotherapy treatment in oncology. [A terapia nutricional com vitaminas antioxidantes e o tratamento quimioterápico oncológico]. Rev. Bras. Cancerol. 47: 303-308.
40. Silva CRM and Naves MMV (2001). Vitamin supplementation in cancer chemoprevention. [Suplementação de vitaminas na prevenção de câncer]. Rev. Nutr. 14: 135-143.
41. Tallaj JA, Franco V, Rayburn BK, Pinderski L, et al. (2005). Response of doxorubicin-induced cardiomyopathy to the current management strategy of heart failure. J. Heart Lung Transplant. 24: 2196-2201.
42. Trekli MC, Riss G, Goralczyk R and Tyrrell RM (2003). β-carotene suppresses UVA-induced HO-1 gene expression in cultured FEK4. Free Radic. Biol. Med. 34: 456-464.
43. Zhang P and Omaye ST (2001). Antioxidant and prooxidant roles for β-carotene, α-tocopherol and ascorbic acid in human lung cells. Toxicol. In Vitro 15: 13-24.