Effect of organic tomato (Lycopersicon esculentum) extract on the genotoxicity of doxorubicin in the Drosophila wing spot test

Genetics and Molecular Biology

Volumn 32, Issue 1, 2009, Pages 133-137

  Dutra, Elaine S ^a   Dias, Cristina D ^a   de Araújo, Bethânia C ^a   Castro, Antonio J S ^a   Nepomucen, Júlio C ^a  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Antioxidants; Co genotoxicity; Drosophila melanogaster; Organic tomato; SMART

Indexed keywords

DOXORUBICIN; ORGANIC TOMATO EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG DETOXIFICATION; DRUG METABOLISM; DRUG POTENTIATION; GENETIC RECOMBINATION; GENOTOXICITY; LARVA; NONHUMAN; SOMATIC MUTATION; TOXICITY TESTING; WING SPOT TEST;

DROSOPHILA MELANOGASTER; LYCOPERSICON ESCULENTUM;

EID: 66649126641     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572009005000008     Document Type: Article

References (31)

1. Abreu JR and Stoltenborg H (1998) A agricultura orgânica e o mercado de frutas e hortaliças orgânicas: Panorama mundial e situação no estado de São Paulo. Agricultura Biodinâmica 80:9-14.
2. Amara-Mokrane YA, Lehucher-Michel MP, Balasard G, Dumenil G and Botta A (1996) Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. Mutagenesis 11:161-167.
3. Antunes LMG and Takahashi CS (1998) Effects of high doses of vitamins C and E against doxorubicin-induced chromosomal damage in Wistar rat bone marrow cells. Mutat Res 419:137-143.
4. Costa WF and Nepomuceno JC (2003) Efeito protetor do chá de cogumelo do sol (Agaricus blazei Murill) contra a ação genotóxica do uretano em células somáticas de Drosophila melanogaster. Rev Ciênc Farma 24:153-158.
5. Costa WF and Nepomuceno JC (2006) Protective effects of a mixture of antioxidant vitamins and mineral on the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Environ Mol Mutagen 47:18-24.
6. Farhan H and Cross HS (2002) Transcriptional inhibition of CYP24 by ginestein. Ann NY Acad Sci 973:459-462.
7. Fragiorge EJ, Spanó MA and Antunes LMG (2007) Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Genet Mol Biol 30:449-455.
8. Frei H and Würgler FE (1995) Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat Res 334:247-258.
9. Frei H and Würgler FE (1996) Induction of somatic and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster. Mutagenesis 11:315-325.
10. Frei H and Würgler FE (1988) Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative or inconclusive result. Mutat Res 203:297-308.
11. Gentile JM, Rahimi S, Zwiesler J, Gentile GJ and Ferguson L (1998) Effect of selected antimutagens on the genotoxicity of antitumor agents. Mutat Res 402:289-298.
12. George B, Kaur C, Khurdiya DS and Kapoor HC (2004) Antioxidants in tomato (Lycopersicon esculentum) as a function of genotype. Food Chem 84:45-51.
13. Girennavar B, Jayaprakasha GK and Patil BS (2007) Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. J Food Sci 72:417-421.
14. Graf U, Würgler FE, Katz AJ, Frei H, Juon H, Hall CB and Kale PG (1984) Somatic mutation and recombination test in Drosophila melanogaster. Environ Mutagen 6:153-188.
15. Graf U (1995) Analysis of the relationship between age of larvae at mutagen treatment and frequency and size of spots in the wing somatic mutation and recombination test in Drosophila melanogaster. Experientia 51:168-173.
16. Graf U, Spanó MA, Rincón JG, Abraham SK and Andrade HH (1996) The wing Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster: An efficient tool for detection of genotoxic activity of pure compounds or complex mixtures as well as for studies on antigenotoxic. Afr Newslett Occup Health Safety 6:9-13.
17. Heber D and Lu QY (2002) Overview of mechanisms of action of lycopene. Exp Biol Med 227:920-923.
18. Ito Y, Maeda S and Sugyama T (1986) Suppression of 7,12-dimethylbenz[a]anthracene-induced chromosome aberrations in rat bone marrow cells by vegetable juices. Mutat Res 172:55-60.
19. Keizer HG, Pinedo HM, Schuurhuis GJ and Joenje H (1990) Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 47:219-231.
20. Lehmann M, Graf U, Reguly ML and Andrade HHR (2000) Interference of tannic acid on the genotoxicity of mitomicin C, methylmethanesulfonate, and nitrogen mustard in somatic cell of Drosophila melanogaster. Environ Mol Mutagen 36:195-200.
21. Lehmann M, Franco A, Vilar KSP, Lukza Reguly M and Andrade HHR (2003) Doxorubicin and two of its analogues are preferential inducers of homologous recombination compared with mutational events in somatic cells of Drosophila melanogaster. Mutat Res 539:167-175.
22. McFadyen MCE, Melvin WT and Murray GI (2004) Cytochrome P450 enzymes: novel options for cancer therapeutics. Mol Cancer Ther 3:363-371.
23. Niitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M and Honma Y (2000) Anticancer derivate of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol 58:27-36.
24. Peng Y, Zhang Y and Ye J (2008) Determination of phenolic compounds and ascorbic acid in different fractions of tomato by capillary electrophoresis with electrochemical detection. J Agric Food Chem 56:1838-1844.
25. Ren H, Endo H and Hayashi T (2001) The superiority of organically cultivated vegetables to general ones regarding antimutagenic activities. Mutat Res 496:83-88.
26. Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Willians KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, et al. (2005) Cancer chemotherapy and drug metabolism. Drug Metab Dispos 33:1083-1096.
27. Rodriguez-Arnaiz R, Sortibran AC and Tellez GO (2004) Detection of mitotic recombination and sex chromosome loss induced by adriamycin, chlorambucil, demecolcine, paclitaxel and vinblastine in somatic cells of Drosophila melanogaster in vivo. Mutagenesis 19:121-127.
28. Santos HS and Cruz WMS (2001) A terapia nutricional com vitaminas antioxidantes e o tratamento quimioterápico oncológico. Rev Bras Oncol 47:303-308.
29. Teel RW and Huynh H (1998) Effect of phytochemicals on cytochrome P450-linked alkoxyresorufin O-dealkylase activity. Phytother Res 12:89-93.
30. Torres C, Creus A and Marcos R (1998) Genotoxic activity of four inhibitors of DNA topoisomerases in larval cells of Drosophila melanogaster as measured in the wing spot assay. Mutat Res 413:191-203.
31. Zeljezic D and Garaj-Vrhovac V (2001) Chromosomal aberration and single cell gel electrophoresis (comet) assay in the longitudinal risk assessment of occupational exposure to pesticides. Mutagenesis 16:359-363.