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Volumn 75, Issue 1, 2010, Pages 211-214

Supramolecular interactions between library members modulate the behavior of dynamic combinatorial libraries

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIC COMBINATORIAL LIBRARY; MOLECULAR COMPOSITIONS; NUMERICAL SIMULATION; SUPRAMOLECULAR INTERACTIONS; SUPRAMOLECULAR NETWORKS; TEMPLATE MOLECULES;

EID: 73449108059     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo902296h     Document Type: Article
Times cited : (23)

References (65)
  • 42
    • 33947501546 scopus 로고    scopus 로고
    • For a system with mixed intra- and supramolecular interactions, see: (d) Gasparini, G.; Martin, M.; Prins, L. J.; Scrimin, P. Chem. Commun. 2007, 1340. The intramolecular noncovalent stabilization is referred to as self-templating or as neighboring-group interaction (if the system displays a catalytic activity).
    • For a system with mixed intra- and supramolecular interactions, see: (d) Gasparini, G.; Martin, M.; Prins, L. J.; Scrimin, P. Chem. Commun. 2007, 1340. The intramolecular noncovalent stabilization is referred to as self-templating or as neighboring-group interaction (if the system displays a catalytic activity).
  • 43
    • 46149100860 scopus 로고    scopus 로고
    • For an example of neighboring-group interaction, see: e
    • For an example of neighboring-group interaction, see: (e) Gasparini, G.; Prins, L. J.; Scrimin, P. Angew. Chem., Int. Ed. 2008, 47, 2475.
    • (2008) Angew. Chem., Int. Ed , vol.47 , pp. 2475
    • Gasparini, G.1    Prins, L.J.2    Scrimin, P.3
  • 44
    • 21844460574 scopus 로고    scopus 로고
    • For examples of self-templating, see: (f) Krishnan-Ghosh, Y, Whitney, A. M, Balasubramanian, S. Chem. Commun. 2005, 3068
    • For examples of self-templating, see: (f) Krishnan-Ghosh, Y.; Whitney, A. M.; Balasubramanian, S. Chem. Commun. 2005, 3068.
  • 47
    • 73449136567 scopus 로고    scopus 로고
    • i (complexed and free) present in the templated library and the corresponding concentration in the nontemplated library. See refs 4b, 5a, and 5d.
    • i (complexed and free) present in the templated library and the corresponding concentration in the nontemplated library. See refs 4b, 5a, and 5d.
  • 48
    • 1942489258 scopus 로고    scopus 로고
    • Some RNA structures exhibit a strong correlation between size and binding affinity, reflecting the fact that larger structures have more potential information content. See: Carothers, J. M.; Oestreich, S. C.; Davis, J. H.; Szostak, J. W. J. Am. Chem. Soc. 2004, 126, 5130. In order to resemble this evidence we assigned a higher KiT to the largest oligomers. Although large oligomers in dynamic systems tend to be more sensitive to disruption of amplification by relativelyweak interactions involving smaller oligomers, larger species are potentially more interesting from a functional point of view.
    • Some RNA structures exhibit a strong correlation between size and binding affinity, reflecting the fact that larger structures have more potential information content. See: Carothers, J. M.; Oestreich, S. C.; Davis, J. H.; Szostak, J. W. J. Am. Chem. Soc. 2004, 126, 5130. In order to resemble this evidence we assigned a higher KiT to the largest oligomers. Although large oligomers in dynamic systems tend to be more sensitive to disruption of amplification by relativelyweak interactions involving smaller oligomers, larger species are potentially more interesting from a functional point of view.
  • 49
    • 70349563367 scopus 로고    scopus 로고
    • The formation of interlocked structures from DCLs in the absence of guest could be considered a particular case of noncovalent interaction between library members. Some examples: (a) Au-Yeung, H. Y, Pantos, G. D, Sanders, J. K. M. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 10466
    • The formation of interlocked structures from DCLs in the absence of guest could be considered a particular case of noncovalent interaction between library members. Some examples: (a) Au-Yeung, H. Y.; Pantos, G. D.; Sanders, J. K. M. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 10466.
  • 53
    • 73449084293 scopus 로고    scopus 로고
    • It could be expected that the distribution of the interactions between library members will affect amplification in different degrees. For example, it is expected that a given affinity between dimers will have a different effect on the amplification than the same affinity between tetramers. Also, it is expected that the size of the DCL will affect the influence of supramolecular interactions on the amplification factor.
    • It could be expected that the distribution of the interactions between library members will affect amplification in different degrees. For example, it is expected that a given affinity between dimers will have a different effect on the amplification than the same affinity between tetramers. Also, it is expected that the size of the DCL will affect the influence of supramolecular interactions on the amplification factor.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.