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For a system with mixed intra- and supramolecular interactions, see: (d) Gasparini, G.; Martin, M.; Prins, L. J.; Scrimin, P. Chem. Commun. 2007, 1340. The intramolecular noncovalent stabilization is referred to as self-templating or as neighboring-group interaction (if the system displays a catalytic activity).
-
For a system with mixed intra- and supramolecular interactions, see: (d) Gasparini, G.; Martin, M.; Prins, L. J.; Scrimin, P. Chem. Commun. 2007, 1340. The intramolecular noncovalent stabilization is referred to as self-templating or as neighboring-group interaction (if the system displays a catalytic activity).
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For an example of neighboring-group interaction, see: e
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For examples of self-templating, see: (f) Krishnan-Ghosh, Y.; Whitney, A. M.; Balasubramanian, S. Chem. Commun. 2005, 3068.
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i (complexed and free) present in the templated library and the corresponding concentration in the nontemplated library. See refs 4b, 5a, and 5d.
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i (complexed and free) present in the templated library and the corresponding concentration in the nontemplated library. See refs 4b, 5a, and 5d.
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48
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1942489258
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Some RNA structures exhibit a strong correlation between size and binding affinity, reflecting the fact that larger structures have more potential information content. See: Carothers, J. M.; Oestreich, S. C.; Davis, J. H.; Szostak, J. W. J. Am. Chem. Soc. 2004, 126, 5130. In order to resemble this evidence we assigned a higher KiT to the largest oligomers. Although large oligomers in dynamic systems tend to be more sensitive to disruption of amplification by relativelyweak interactions involving smaller oligomers, larger species are potentially more interesting from a functional point of view.
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Some RNA structures exhibit a strong correlation between size and binding affinity, reflecting the fact that larger structures have more potential information content. See: Carothers, J. M.; Oestreich, S. C.; Davis, J. H.; Szostak, J. W. J. Am. Chem. Soc. 2004, 126, 5130. In order to resemble this evidence we assigned a higher KiT to the largest oligomers. Although large oligomers in dynamic systems tend to be more sensitive to disruption of amplification by relativelyweak interactions involving smaller oligomers, larger species are potentially more interesting from a functional point of view.
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49
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The formation of interlocked structures from DCLs in the absence of guest could be considered a particular case of noncovalent interaction between library members. Some examples: (a) Au-Yeung, H. Y, Pantos, G. D, Sanders, J. K. M. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 10466
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The formation of interlocked structures from DCLs in the absence of guest could be considered a particular case of noncovalent interaction between library members. Some examples: (a) Au-Yeung, H. Y.; Pantos, G. D.; Sanders, J. K. M. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 10466.
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(d) Furlan, R. L. E.; Otto, S.; Sanders, J. K. M. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 4801.
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It could be expected that the distribution of the interactions between library members will affect amplification in different degrees. For example, it is expected that a given affinity between dimers will have a different effect on the amplification than the same affinity between tetramers. Also, it is expected that the size of the DCL will affect the influence of supramolecular interactions on the amplification factor.
-
It could be expected that the distribution of the interactions between library members will affect amplification in different degrees. For example, it is expected that a given affinity between dimers will have a different effect on the amplification than the same affinity between tetramers. Also, it is expected that the size of the DCL will affect the influence of supramolecular interactions on the amplification factor.
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