IFNβ-1a therapy for multiple sclerosis expands regulatory CD8+ T cells and decreases memory CD8+ subset: A longitudinal 1-year study

Clinical Immunology

Volumn 134, Issue 2, 2010, Pages 148-157

  Aristimuño, Carol ^a   de Andrés, Clara ^a   Bartolomé, Manuel ^b   de las Heras, Virginia ^b   Martínez Ginés, Ma Luisa ^a   Arroyo, Rafael ^b   Fernández Cruz, Eduardo ^a   Sánchez Ramón, Silvia ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

Author keywords

CD8+ T cells; Interferon 1a; Multiple sclerosis; Regulatory T lymphocytes

Indexed keywords

BETA1A INTERFERON; CD27 ANTIGEN; CD38 ANTIGEN; CD45RO ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; GRANZYME B; HLA DR3 ANTIGEN; INTERLEUKIN 10; METHYLPREDNISOLONE; TRANSFORMING GROWTH FACTOR BETA; BETA INTERFERON; CYTOKINE; IMMUNOLOGICAL ADJUVANT;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; EFFECTOR CELL; EX VIVO STUDY; FEMALE; HUMAN; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; RELAPSE; BLOOD; CELL SEPARATION; CLINICAL TRIAL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADJUVANTS, IMMUNOLOGIC; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-BETA; LONGITUDINAL STUDIES; MALE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 73349129340     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.09.008     Document Type: Article

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