Bcl-2/adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death

Journal of Neuropathology and Experimental Neurology

Volumn 68, Issue 12, 2009, Pages 1326-1338

  Walls, K C ^a,b   Ghosh, Arindam P ^a,c   Ballestas, Mary E ^d   Klocke, Barbara J ^a   Roth, Kevin A ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Apoptosis; Apoptosis inducing factor; BNIP3; Hypoxia

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE INHIBITOR; COBALT CHLORIDE; DEFEROXAMINE; FIBROBLAST GROWTH FACTOR 2; GLUCOSE; OXYGEN; PROTEIN BAK; PROTEIN BAX; PROTEIN BNIP3; BNIP3 PROTEIN, MOUSE; ENZYME INHIBITOR; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; HYPOXIA; MALE; MOUSE; NERVE CELL NECROSIS; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL HYPOXIA; CONFOCAL MICROSCOPY; DRUG EFFECT; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEM CELL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL HYPOXIA; ENZYME ACTIVATION; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MITOCHONDRIAL PROTEINS; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 73349096287     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181c3b9be     Document Type: Article

References (38)

1. Romanko MJ, Zhu C, Bahr BA, et al. Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia. J Neuro-chem 2007;103:1121-1131
2. An WG, Kanekal M, Simon MC, et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998;392:405-408
3. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54
4. 2-regulated prolyl hydroxylation. Science 2001;292:468-472
5. 2 sensing. Science 2001;292:464-468
6. Berra E, Roux D, Richard DE, et al. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm. EMBO Rep 2001;2:615-620
7. Richard DE, Berra E, Gothie E, et al. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1>) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999;274: 32631-32637
8. Berra E, Richard DE, Gothie E, et al. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1> degradation. FEBS Lett 2001;491:85-90
9. Hirsila M, Koivunen P, Xu L, et al. Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J 2005;19: 1308-1310
10. Guo M, Song LP, Jiang Y, et al. Hypoxia-mimetic agents desferriox-amine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis 2006;11:67-77
11. Clarke PG. Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990;181:195-213
12. Akhtar RS, Ness JM, Roth KA. Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim Biophys Acta 2004;1644: 189-203
13. Azad MB, Chen Y, Henson ES, et al. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 2008;4:195-204
14. Vande VC, Cizeau J, Dubik D, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 2000;20:5454-5468
15. Kanzawa T, Zhang L, Xiao L, et al. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005;24:980-991
16. Zhang L, Li L, Liu H, et al. HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochon-drial-dependent cell death. Free Radic Biol Med 2007;43:117-127
17. Daido S, Kanzawa T, Yamamoto A, et al. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004;64:4286-4293
18. Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1Ydependent autophagy. Cell 2005;122:927-939
19. Zhang H, Bosch-Marce M, Shimoda LA, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008;283:10892-10903
20. Knudson CM, Tung KS, Tourtellotte WG, et al. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 1995;270: 96-99
21. Geng Y, Akhtar RS, Shacka JJ, et al. p53 transcription-dependent and-independent regulation of cerebellar neural precursor cell apoptosis. J Neuropathol Exp Neurol 2007;66:66-74
22. Snyder EY, Deitcher DL, Walsh C, et al. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 1992;68:33-51
23. Filiano AJ, Bailey CD, Tucholski J, et al. Transglutaminase 2 protects against ischemic insult, interacts with HIF1A, and attenuates HIF1 signaling. FASEB J 2008;22:2662-2675
24. Tracy K, Dibling BC, Spike BT, et al. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 2007;27: 6229-6242
25. Akhtar RS, Geng Y, Klocke BJ, et al. Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death Differ 2006;13: 1727-1739
26. Chen G, Cizeau J, Vande VC, et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem 1999;274:7-10
27. Fei P, Wang W, Kim SH, et al. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 2004; 6:597-609
28. Zhang Z, Yang X, Zhang S, et al. BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. Stroke 2007;38:1606-1613
29. Tracy K, Macleod KF. Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy 2007;3:616-619
30. Zhu C, Wang X, Huang Z, et al. Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ 2007;14:775-784
31. Brazel CY, Nunez JL, Yang Z, et al. Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone. Neuroscience 2005;131:55-65
32. Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apopto-sis. Science 2004;303:1010-1014
33. Kubli DA, Quinsay MN, Huang C, et al. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 2008;295:H2025-31
34. Kubli DA, Ycaza JE, Gustafsson AB. Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J 2007;405: 407-415
35. Ray R, Chen G, Vande VC, et al. BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem 2000;275:1439-1448
36. Diwan A, Krenz M, Syed FM, et al. Inhibition of ischemic cardiomyo-cyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest 2007;117:2825-2833
37. Hochhauser E, Cheporko Y, Yasovich N, et al. Bax deficiency reduces infarct size and improves long-term function after myocardial infarction. Cell Biochem Biophys 2007;47:11-20
38. Zhu C, Wang X, Deinum J, et al. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med 2007;204:1741-1748