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Volumn , Issue 1, 2010, Pages 174-182

Enantioselective Fujiwara-Moritani indole and pyrrole annulations catalyzed by chiral palladium(II)-NicOx complexes

Author keywords

Asymmetric catalysis; C H activation; Fujiwara Moritani reaction; Heck reaction; Palladium

Indexed keywords


EID: 73349094985     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200901129     Document Type: Article
Times cited : (76)

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    • We had desperately attempted to secure the absolute configuration for months yet all efforts were futile. Although we were able to further functionalize both the heterocycles itself and the hindered alkene, all enantioenriched samples crystallized as racemates without exception (even from 90% ee samples, Chemical correlation failed as well. We also prepared a >99, ee sample of annulated pyrrole, )-42 decorated with three bromine atoms by chiral HPLC separation, which was then reluctant to crystallize cf. Supporting Information, We sincerely thank Dr. Roland Fröhlich for several X-ray crystal structure analyses of racemates
    • We had desperately attempted to secure the absolute configuration for months yet all efforts were futile. Although we were able to further functionalize both the heterocycles itself and the hindered alkene, all enantioenriched samples crystallized as racemates without exception (even from 90% ee samples). Chemical correlation failed as well. We also prepared a >99 % ee sample of annulated pyrrole (+)-42 decorated with three bromine atoms by chiral HPLC separation, which was then reluctant to crystallize (cf. Supporting Information). We sincerely thank Dr. Roland Fröhlich for several X-ray crystal structure analyses of racemates.
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