A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon

American Journal of Gastroenterology

Volumn 94, Issue 6, 1999, Pages 1696-1698

  Guyader, Dominique ^a   Boucher, Eveline ^a   André, Patrice ^b   Even, Christian ^c   Cottereau, Jean ^c   Bianchi, Alain ^c   Gasser, Patrick ^c   Mendler, Michel H ^a   Deugnier, Yves ^a   Brissot, Pierre ^a  

^a INSERM   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c Centres Hospitaliers de Caen   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; AMINOTRANSFERASE; IRON; VIRUS RNA;

ADJUVANT THERAPY; ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; DRUG RESISTANCE; FEMALE; HEPATITIS C; HUMAN; IRON BLOOD LEVEL; IRON OVERLOAD; IRON THERAPY; MALE; PHLEBOTOMY; PILOT STUDY; PRIORITY JOURNAL; VIREMIA;

EID: 0032975993     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1999.01170.x     Document Type: Article

References (7)

1. Bonkovsky H.L., Banner B.F., Rothman A.L. Iron and chronic viral hepatitis. Hepatology. 25:1997;759-768.
2. Bacon B.R., Rebholz A.E., Fried M., et al. Beneficial effect of iron reduction therapy in patients with chronic hepatitis C who failed to respond to interferon alpha. Hepatology. 18:1993;150A.
3. Hayashi H., Takikawa T., Nishimura N., et al. Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. Am J Gastroenterol. 89:1994;986-988.
4. Hayashi H., Takikawa T., Nishimura N., et al. Serum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C. J Hepatol. 22:1995;268-271.
5. Piperno A., Sampietro M., D'Alba R., et al. Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C. Liver. 16:1996;248-254.
6. Hoofnagle J.H., Di Bisceglie A.M. The treatment of chronic viral hepatitis. N Engl J Med. 336:1997;347-350.
7. Beinker N.K., Voigt M.D., Arendse M., et al. Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C. J Hepatol. 25:1996;633-638.