Oxidative stress in resuscitation and in ventilation of newborns

European Respiratory Journal

Volumn 34, Issue 6, 2009, Pages 1461-1469

  Gitto, E ^a   Pellegrino, S ^a   D'Arrigo, S ^a   Barberi, I ^a   Reiter, R J ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Bronchopulmonary dysplasia; Modality of ventilation; Newborn; Oxidative stress; Respiratory distress syndrome

Indexed keywords

REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

AMBIENT AIR; ARTIFICIAL VENTILATION; CESAREAN SECTION; CHRONIC LUNG DISEASE; DELIVERY; HIGH FREQUENCY VENTILATION; HUMAN; LABOR; LUNG DYSPLASIA; LUNG INJURY; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; OXIDATIVE STRESS; OXYGEN BREATHING; PREMATURITY; PRIORITY JOURNAL; RESUSCITATION; REVIEW; TREATMENT OUTCOME;

ANIMALS; CHRONIC DISEASE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LUNG DISEASES; MODELS, BIOLOGICAL; OXIDATIVE STRESS; OXYGEN INHALATION THERAPY; REACTIVE OXYGEN SPECIES; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN; RESUSCITATION; TREATMENT OUTCOME;

EID: 73249130392     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00032809     Document Type: Review

References (104)

1. Halliwell B. Free radicals, antioxidants and human disease: Curiosity, cause, or consequence? Lancet 1999; 344: 721-724.
2. Fridovich I. Oxygen toxicity: a radical explanation. J Exp Biol 1998; 201: 1203-1209.
3. Gitto E, Reiter RJ, Karbownik M, et al. Causes of oxidative stress in the pre-and perinatal period. Biol Neonate 2002; 81: 146-157.
4. Halliwell B. Oxygen radicals as key mediators in neurological disease: Fact or fiction? Ann Neurol 1992; 32: S10-S15.
5. Saugstad OD. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatr 1996; 85: 1-4.
6. Sarker AH, Watanabe S, Seki S, et al. Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system. Mutat Res 1995; 337: 85-95.
7. Saugstad OD. Bronchopulmonary dysplasia - oxidative stress and antioxidants. Semin Neonatol 2003; 8: 39-49.
8. Saugstad OD. Oxidative stress in the newborn. A 30-year perspective. Biol Neonate 2005; 88: 228-236.
9. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 1988; 23: 143-150.
10. Haynes RL, Folkerth RD, Keefe RJ, et al. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol 2003; 62: 441-450.
11. Clyman RI, Saugstad OD, Mauray F. Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production. Circ Res 1989; 64: 1-8.
12. Archer SL, Peterson D, Nelson DP, et al. Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. J Appl Physiol 1989; 66: 102-111.
13. Sanderud J, Bjoro K, Saugstad OD. Oxygen radicals stimulate thromboxane and prostacyclin synthesis and induce vasoconstriction in pig lungs. Scand J Clin Lab Invest 1993; 53: 447-455.
14. Ogihara T, Okamoto R, Kim H, et al. New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease. Pediatr Res 1996; 39: 117-119.
15. Shoji H, Koletzko B. Oxidative stress and antioxidant protection in the perinatal period. Curr Opin Clin Nutr Metab Care 2007; 10: 324-328.
16. Argüelles S, Markado MJ, Ayala A, et al. Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth. Free Radic Res 2006; 40: 565-570.
17. Fogel I, Pinchuk I, Kupferminc MJ, et al. Oxidative stress in the fetal circulation does not depend on mode of delivery. Am J Obstet Gynecol 2005; 193: 241-246.
18. Hracsko Z, Safar Z, Orvos H, et al. Evaluation of oxidative stress markers after vaginal delivery or caesarean section. In Vivo 2007; 21: 703-706.
19. Laurie S, Mataz Z, Boaz M, et al. Different degrees of fetal oxidative stress in elective and emergent caesarean section. Neonatology 2007; 92: 111-115.
20. Kattwinkel J, Niermeyer S, Nadkarni V, et al. ILCOR advisory statement: resuscitation of the newly born infant. An advisory statement from the pediatric working group of the International Liaison Committee on Resuscitation. Circulation 1999; 99: 1927-1938.
21. Niermeyer S, Kattwinkel J, Van Reempts P, et al. International Guidelines for Neonatal Resuscitation: an excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and Reviewers for the Neonatal Resuscitation Guidelines. Pediatrics 2000; 106: e29.
22. Lefkowitz W. Oxygen and resuscitation: beyond the myth. Pediatrics 2002; 109: 517-519.
23. Saugstad OD, Aansen AO. Plasma hypoxanthine levels as a prognostic aid of tissue hypoxia. Eur Surg Res 1980; 12: 123-129.
24. Armstead WM, Mirro R, Busija DW, et al. Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 1988; 255: H401-H403.
25. Bagenholm R, Nilsson UA, Gotborg CW, et al. Free radicals are formed in the brain of fetal sheep during reperfusion after cerebral ischemia. Pediatr Res 1998; 43: 271-275.
26. Kondo M, Itoh S, Isobe K, et al. Chemiluminescence because of the production of reactive oxygen species in the lungs of newborn piglets during resuscitation periods after asphyxiation load. Pediatr Res 2000; 47: 524-527.
27. Kutzsche S, Ilves P, Kirkeby OJ, et al. Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets. Pediatr Res 2002; 49: 834-842.
28. Vento M, Asensi M, Sastre J, et al. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics 2001; 107: 642-647.
29. Saugstad OD. Is oxygen more toxic than currently believed? Pediatrics 2001; 108: 1203-1205.
30. Saugstad OD. Resuscitation of newborn infants with room air or oxygen. Semin Neonatol 2001; 6: 233-239.
31. Ramji A, Ahuja S, Thirupuram S, et al. Resuscitation of asphyxic newborn infants with room air or 100% oxygen. Pediatr Res 1993; 34: 809-812.
32. Saugstad OD, Rootwelt T, Aalen O. Resuscitation of asphyxiated newborn infants wiyh room air or oxygen: an international controlled trial the Resair 2 study. Pediatr Res 1998; 102: e1.
33. Vento M, Asensi M, Sastre J, et al. Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants. Biol Neonate 2001; 79: 261-267.
34. Vento M, Sastre J, Asensi M, et al. Oxidative stress in asphyxiated term infants resusciteted with 100% oxygen. J Pediatr 2003; 142: 240-246.
35. Ramji S, Rasaily R, Mishra PK, et al. Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial. Ind Pediatr 2003; 40: 510-517.
36. Saugstad OD, Ramji S, Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a metaanalysis. Biol Neonate 2005; 87: 22-34.
37. Tan A, Schulze A, O'Donnell CP, et al. Air versus oxygen for resuscitation of infants at birth. Cochrane Database Syst Rev 2005; 18: CD002273.
38. Raby Y, Rabi D, Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation 2007; 72: 353-363.
39. Saugstad OD. Optimal oxygenation at birth and in the neonatal period. Neonatology 2007; 91: 319-322.
40. Escrig R, Arruza L, Izquierdo I, et al. Achievement of targeted saturation values in extremely low gestational age neonates resuscitated with low or high oxygen concentrations: a prospective randomized trial. Pediatrics 2008; 121: 875-881.
41. Saugstad OD. Oxygen toxicity at birth: the pieces are put together. Pediatr Res 2003; 789-783.
42. Naumburg E, Belloco R, Gnattingius S, et al. Supplementary oxygen and risk of childhood lymphatic leukaemia. Acta Pediatr 2002; 91: 1328-1233.
43. Bajaj N, Udani RH, Nanavati RN. Room air versus 100 percent oxygen for neonatal resuscitation: a controlled clinical trial. J Top Pediatr 2005; 51: 206-211.
44. The Summary of Major Changes to the 2005, AAP/AHA Emergency Cardiovascular Care Guidelines for Neonatal Resuscitation.
45. Zoban P, Cerny M. Immature lung and acute lung injury. Physiol Res 2003; 52: 507-516.
46. Kothecha S. Lung growth: implication for the newborn infant. Arch Dis Child Fetal Neonatal Ed 2000; 82: F69-F74.
47. Bhandari V, Mauli KN, Kresch M. Hyperoxia causes an increase in antioxidant enzyme activity in adult and fetal rat type II pneumocytes. Lung 2000; 178: 53-60.
48. Ikegami M, Kallapur S, Michna J, et al. Lung injury and surfactant metabolism after hyperventilation of premature lambs. Pediatr Res 2000; 47: 398-404.
49. Lamb NJ, Gutteridge JMC, Baker C, et al. Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration and chlorination. Intens Care Med 1999; 25: 1738-1744.
50. Huertas JR, Palomino N, Ochoa JJ, et al. Lipid peroxidation and antioxidant erythrocyte membranes of full-term and preterm newborns. Biofactors 1998; 8: 133-137.
51. Esteban J, Morcillo JE, Cortjo J. Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants. Pharmacol Res 1999; 40: 393-404.
52. Boda D, Nemeth I, Pinter S. Surface tension, glutathione content and redox ratio of the tracheal aspirate fluid of premature infants with IRDS. Biol Neonate 1998; 74: 281-288.
53. Banks BA, Ischiropoulos H, McClelland M, et al. Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia. Pediatrics 1998; 101: 870-874.
54. Dellinger RP. Inhaled nitric oxide in acute lung injury and acute respiratory distress syndrome. Inability to translate physiologic benefit to clinical outcome benefit in adult clinical trials. Intens Care Med 1999; 25: 881-883.
55. Janssen YMW, Soultanakis R, Steece K, et al. Depletion of nitric oxide causes cell cycle alterations, apoptosis and oxidative stress in pulmonary cells. Am J Physiol 1998; 275: L1100-L1109.
56. Kim K, Whitin JC, Sukhova NM, et al. Increases in extracellular glutathione peroxidase in plasma and lungs of mice exposed to hyperoxia. Pediatr Res 1999; 46: 715-721.
57. Ogihara T, Hirano K, Morinobu T, et al. Raised concentrations of aldehyde lipid peroxidation products in premature infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed 1999; 80: F21-F25.
58. Metnitz PGH, Bartens C, Fisher M, et al. Antioxidant status in patient with acute respiratory distress syndrome. Intens Care Med 1999; 25: 180-185.
59. Vento G, Mele MC, Mordente A, et al. High total antioxidant activity and uric acid in tracheobronchial aspirate fluid of preterm infants during oxidative stress: an adaptive response to hyperoxia? Acta Paediatr 2000; 89: 336-342.
60. Yitig S, Yurdakok M, Kilinc K, et al. Serum malondialdehyde concentrations as a measure of oxygen free radical damage in preterm infants. Turk J Pediatr 1998; 40: 177-183.
61. Saugstad OD. Chronic lung disease: the role of oxidative stress. Biol Neonate 1998; 74: Suppl. 1, 21-28.
62. Coalson JJ, Winter VT, Siler-Khodr T, et al. Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999; 160: 1333-1346.
63. Margraf LR, Tomashefski JF Jr, Bruce MC, et al. Morphometric analysis of the lung in bronchopulmonary dysplasia. Am Rev Respir Dis 1991; 143: 391-400.
64. Welty SE. Is Oxidant stress in the causal pathway to BPD? NeoReviews 2000; e6-e10.
65. Welty SE. Is the role for antioxidant therapy in bronchopulmonary dysplasia. J Nutr 2001; 131: 947S-950S.
66. Ogihara T, Hirano K, Morinobu T, et al. Raised concentration of aldehyde lipid peroxidation products in premature infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed 1999; 80: F21-F25.
67. Nycyk JA, Drury JA, Cooke RWI. Breath pentane as a marker for lipid peroxidation and adverse outcome in preterm infants. Arch Dis Child Fetal Neonatal Ed 1998; 79: F67-F69.
68. Varsila E, Pesonen E, Andersson S. Early protein oxidation in the neonatal lung is related to development of chronic lung disease. Acta Paediatr 1995; 84: 1296-1299.
69. Ramsay PL, DeMayo FJ, Hegemier SE, et al. Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 164: 155-161.
70. Bracci R. Free oxygen radicals and surfactant. Biol Neonate 1997; 71: Suppl. 1, 23-27.
71. Delacourt C, D'Ortho M-P, Maquin-Mavier I, et al. Oxidantantioxidant balance in alveolar macrophages from newborn rats. Eur Respir J 1996; 9: 2517-2524.
72. Pittet JF, Mackersie RC, Martin TR, et al. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med 1997; 155: 1187-1205.
73. Groneck P, Reuss D, Gotze-Speer B, et al. Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. J Pediatr 1993; 22: 938-944.
74. Bancalari E, Gonzales A. Clinical course and lung function abnormalities during development of neonatal chronic lung disease. In: Bland RD, Coalson JJ, eds. Chronic Lung Disease in Early Infancy. New York, Marcel Dekker, 2000; pp. 41-64.
75. Speer CP, Groneck P. Oxygen radicals, cytokines, adhesion molecules and lung injury in neonates. Semin Neonatal 1998; 3: 219-228.
76. Arnoon S, Grigg J, Silverman M. Pulmonary inflammatory cells in ventilated preterm infants: effects of surfactant treatment. Arch Dis Child 1993; 69: 44-48.
77. Jonsson B, Tullus K, Brauner A, et al. Early increase of TNF alpha and IL-6 in tracheobronchial aspirate fluid indicator of subsequent chronic lung disease in preterm infants. Arch Dis Child Fetal Neonatal Ed 1997; 77: F198-F201.
78. An H, Nishimaki S, Ohyama M, et al. Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants. Am J Obstet Gynecol 2004; 191: 1649-1654.
79. Bancalari E. Epidemiology and risk factors for the "new" bronchopulmonary dysplasia. NeoReviews 2000; 1: 2-5.
80. Groneck P, Speer CP. Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed 1995; 73: F1-F3.
81. McColm JR, McIntosh N. Interleukin-8 in bronchoalveolar lavage samples as predictor of chronic lung disease in premature infants. Lancet 1994; 343: 729.
82. Schultz C, Tautz J, Reiss I, et al. Prolonged mechanical ventilation induces pulmonary inflammation in preterm infants. Biol Neonate 2003; 84: 64-66.
83. Deng H, Mason SN, Auten RL Jr. Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Am J Respir Crit Care Med 2000; 162: 2316-2323.
84. Kotecha S. Cytokines in chronic lung disease of prematurity. Eur J Pediatr 1996; 155: Suppl. 2, S14-S17.
85. Kotecha S, Chan B, Azam N, et al. Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease. Arch Dis Child Fetal Neonatal Ed 1995; 72: F90-F96.
86. McColm JR, Stenson BJ, Biermasz N, et al. Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants. Arch Dis Child Fetal Neonatal Ed 2000; 82: F156-F159.
87. Jones CA, Cayabyab RG, Kwong KY, et al. Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res 1996; 39: 966-975.
88. Dudley DJ, Hunter C, Mitchell MD, et al. Amniotic fluid interleukin- 10 (IL-10) concentrations during pregnancy and with labor. J Reprod Immunol 1997; 33: 147-156.
89. Saugstad OD. Bronchopulmonary dysplasia-oxidative stress and antioxidants. Semin Neonatol 2003; 8: 39-49.
90. Clark RH, Slutsky AS, Gerstmann DR. Lung protective strategies of ventilation in the neonate: what are they? Pediatrics 1999; 105: 112-114.
91. Ikegami M, Kallapur S, Michna J, et al. Lung injury and surfactant metabolism after hyperventilation of premature lambs. Pediatr Res 2000; 47: 398-404.
92. 2 and neurodevelopmental sequelae following assisted ventilation. Clin Perinatol 1998; 25: 159-175.
93. Ehrenkranz RA, Mercurio MR. Bronchopulmonary dysplasia. In: Sinclair JR, Bracken MB, eds. Effective Care of the Newborn Infant. Oxford, Oxford University Press, 1992; pp. 399-424.
94. Zoban P, Černy M. Immature lung and acute lung injury. Physiol Res 2003; 52: 507-516.
95. Bohn DJ, Miyasaka K, Marchack BE, et al. Ventilation by highfrequency oscillation. J Appl Physiol 1980; 48: 710-716.
96. Gerstmann DR, Fouke JM, Winter DC, et al. Proximal, tracheal, and alveolar pressures during high-frequency oscillatory ventilation in a normal rabbit model. Pediatr Res 1990; 28: 367-373.
97. Bollen CW, Uiterwaal CSPM, van Vught AJ. Cumulative metaanalysis of high-frequency versus conventional ventilation in premature neonates. Am J Respir Crit Care Med 2003; 168: 1150-1155.
98. Cools F, Henderson-Smart DJ, Offringa M, et al. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev 2007; 18: CD000104.
99. Donn SM, Sinha SK. Can mechanical ventilation strategies reduce chronic lung disease? Semin Neonatol 2003; 8: 441-448.
100. Herrera CM, Gerhardt T, Claure N, et al. Effect of volume guaranteed synchronized intermittent mandatory ventilation in preterm infants recovering from respiratory failure. Pediatrics 2003; 110: 529-533.
101. Lista G, Colnaghi, M, Castoldi F, et al. Impact of targeted-volume ventilation on lung inflammatory response in preterm infants with respiratory distress syndrome (RDS). Pediatr Pulmonol 2004; 37: 510-514.
102. Dani C, Bertini G, Pezzati M, et al. Effects of pressure support ventilation plus volume guarantee vs. high-frequency oscillatory ventilation on lung inflammation in preterm infants. Pediatric Pulmonol 2006; 41: 242-249.
103. Thomas W, Speer CP. Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia - what is the evidence? Neonatology 2008; 94: 150-159.
104. Gitto E, Pellegrino S, Gitto B, et al. Oxidative stress in the newborn in the pre- and post-natal period and the clinical use of melatonin. J Pineal Res 2009; 46: 128-139.