Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants

Biology of the Neonate

Volumn 79, Issue 3-4, 2001, Pages 261-267

  Vento, Max ^a,b,d   Asensi, Miguel ^c   Sastre, Juan ^c   García Sala, Fernando ^a,b   Viña, José ^c  

^a Hospital Virgen del Consuelo   (Spain)

^b UNIVERSITY OF ALICANTE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d Hospital Virgen del Consuelo   (Spain)

Author keywords

Asphyxia; Glutathione; Newly born infant; Oxidative stress; Resuscitation; Room air

Indexed keywords

ANTIOXIDANT; GLUTATHIONE;

AMBIENT AIR; BLOOD GAS; BREATHING PATTERN; CONFERENCE PAPER; HUMAN; HYPEROXIA; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN HYPOXIA; NEWBORN MORBIDITY; NEWBORN MORTALITY; OXIDATIVE STRESS; OXYGEN CONCENTRATION; PERINATAL PERIOD; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RESUSCITATION;

ASPHYXIA NEONATORUM; CARBON DIOXIDE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; INFANT, NEWBORN; OXIDATION-REDUCTION; OXYGEN; RESPIRATION; RESUSCITATION; SUPEROXIDE DISMUTASE;

EID: 0035080404     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047103     Document Type: Conference Paper

References (31)

1. World Health Report. Geneva, World Health Organisation, 1995.
2. Child Health Development: Health of the Newborn. Geneva, World Health Organisation, 1991.
3. Saugstad OD: Practical aspects of resuscitating asphyxiated newborn infants. Eur J Pediatr 1998; 157(suppl 1):S11-S15.
4. Palme-Kilander C: Methods of resuscitation in low Apgar-score newborn infants: A national survey. Acta Paediatr 1992;81:739-744.
5. International Guidelines for Neonatal Resuscitation: An Excerpt From the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Pediatrics 2000;106:e29.
6. Fellman V, Raivio KO: Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res 1997;41:599-606.
7. Saugstad OD: Resuscitation with room-air or oxygen supplementation. Clin Perinatol 1998;25:741-756.
8. Edwards AD, Azzopardi DV: Perinatal hypoxia-ischemia and brain injury. Pediatr Res 2000;47: 431-432.
9. Ramji S, Ahuja S, Thirupuram S, Rootwelt T, Aalen O: Resuscitation of asphyxiated newborn infants with room air or 100% oxygen. Pediatr Res 1993;34:809-812.
10. Saugstad OD, Rootwelt T, Aalen O: Resuscitation of asphyxiated newborn infants with room air or oxygen: An international controlled trial: The Resair 2 Study. Pediatrics 1998;102:e1.
11. Vento M, Asensi M, Sastre J, García-Sala F, Pallardo FV, Viña J: Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics, in press.
12. Sastre J, Asensi M, Rodrigo F, Pallardó FV, Vento M, Viña J: Antioxidant administration to the mother prevents oxidative stress associated with birth. Life Sci 1994;54:2055-2059.
13. Vento M, Asensi M, García-Sala F, Catalá J, Viña J: Oxidative stress caused by fetal-neonatal transition in humans. Pediatr Res 1995;38:460A.
14. Vento M, Asensi M, García-Sala F, Viña J, Asensi MA, Sastre J: The use of room air ventilation enhances the establishment of a sustained spontaneous respiratory pattern after perinatal asphyxia. Pediatr Res 2000;47:438A.
15. American Academy of Pediatrics/American Heart Association: Textbook of Neonatal Resuscitation. Dallas, American Heart Association, 1994.
16. Asensi M, Sastre J, Pallardó FV, Lloret S, Lehner M, García de la Asunción J, Viña J: Ratio of reduced to oxidised glutathione as indicator of oxidative stress status and DNA damage. Methods Enzymol 1999;299:267-276.
17. Asensi MA, Sastre J, Pallardó FV, García de la Asunción J, Estrela JM, Viña J: A high-performance liquid chromatography method for measurement of oxidized glutathione in biological samples. Anal Biochem 1994;217:323-328.
18. Flohé L, Güzzler WA: Assays on glutathione peroxidase. Methods Enzymol 1984;105:114-121.
19. Flohé L, Otting F: Superoxide dismutase assays. Methods Enzymol 1984;105:93-104.
20. Aebi H: Catalase in vitro. Methods Enzymol 1984; 105:121-126.
21. Hutchinson AA: Recovery from hypnoea in preterm lambs: Effects of breathing air or oxygen. Pediatr Pulmonol 1987;3:317-323.
22. Mortola JP, Frapell PB, Dotta A, Matsuoka T, Fox G, Weeks S, Mayer D: Ventilatory and metabolic responses to acute hyperoxia in newborns. Am Rev Respir Dis 1992;146:11-15.
23. Lundstrøm K, Pryds O, Greisen G: Oxygen at birth and prolonged cerebral vasoconstriction in preterm infants. Arch Dis Child 1995;73:F81-F86.
24. Nakai A, Asakura H, Taniuchi Y, Koshino T, Araki T, Siesjö BK: Effect of α-phenyl-N-tert-butyl nitrone (PBN) on fetal cerebral energy metabolism during intrauterine ischemia and reperfusion in rats. Pediatr Res 2000;47:451-456.
25. Siesjö BK, Siesjö P: Mechanisms of secondary brain injury. Eur J Anaesthesiol 1996;13:247-268.
26. Kontos HA: Oxygen radicals in cerebral vascular injury. Circ Res 1985;57:508-516.
27. Siesjö BK, Agardh C-D, Bengtsson F: Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1989;1:165-211.
28. Taylor DL, Edwards AD, Mehmet H: Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol 1999;9:93-117.
29. Beckman KB, Ames BN: The free radical theory of aging matures. Physiol Rev 1998;78:547-581.
30. Finkel T: Oxygen radicals and signaling. Curr Opin Cell Biol 1998;10:248-253.
31. Kowaltowski AJ, Vercesi A: Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 1999;26:463-471.