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Volumn 16, Issue 5, 2009, Pages 641-653

Poly (ADP-ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE -/- mice with hyperhomocysteinemia

Author keywords

Atherosclerosis; Hyperhomocysteinemia; Oxidative stress; Proinflammatory

Indexed keywords

3 AMINOBENZAMIDE; APOLIPOPROTEIN E; HOMOCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); VASCULAR CELL ADHESION MOLECULE 1;

EID: 73249118267     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.1586     Document Type: Article
Times cited : (20)

References (52)
  • 1
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA, 1995; 274: 1049-1057
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 2
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA: Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation, 1997; 95: 1119-1121
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 4
    • 0033985265 scopus 로고    scopus 로고
    • Homocysteine and endothelial dysfunction: A link with cardiovascular disease
    • McDowell IF, Lang D: Homocysteine and endothelial dysfunction: A link with cardiovascular disease. J Nutr, 2000; 130 (2S suppl): 369S-372S
    • (2000) J Nutr , vol.130 , Issue.2S SUPPL.
    • McDowell, I.F.1    Lang, D.2
  • 6
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev, 2007; 87: 315-424
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 7
    • 13244290059 scopus 로고    scopus 로고
    • Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: Mechanistic insights
    • Rubbo H, O'Donnell V: Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: Mechanistic insights. Toxicology, 2005; 208: 305-317
    • (2005) Toxicology , vol.208 , pp. 305-317
    • Rubbo, H.1    O'Donnell, V.2
  • 9
    • 0034171108 scopus 로고    scopus 로고
    • Myocardial postischemic injury is reduced by poly (ADP -ribose) polymerase-1 gene disruption
    • Pieper AA, Walles T, Wei G, Clements EE, Verma A, Snyder SH, Zweier JL: Myocardial postischemic injury is reduced by poly (ADP -ribose) polymerase-1 gene disruption. Mol Med, 2006; 6: 271-282
    • (2006) Mol Med , vol.6 , pp. 271-282
    • Pieper, A.A.1    Walles, T.2    Wei, G.3    Clements, E.E.4    Verma, A.5    Snyder, S.H.6    Zweier, J.L.7
  • 10
    • 0034999274 scopus 로고    scopus 로고
    • Poly ADP -ribose polymerase inhibitors prevent the upregulation of ICAM-1 and E-selectin in response to Th1 cytokine stimulation
    • Sharp C, Warren A, Oshima T, Williams L, Li JH, Alecander JS: Poly ADP -ribose polymerase inhibitors prevent the upregulation of ICAM-1 and E-selectin in response to Th1 cytokine stimulation. Inflammation, 2001; 25: 157-163
    • (2001) Inflammation , vol.25 , pp. 157-163
    • Sharp, C.1    Warren, A.2    Oshima, T.3    Williams, L.4    Li, J.H.5    Alecander, J.S.6
  • 11
    • 0036710459 scopus 로고    scopus 로고
    • The functional role of poly (ADP -ribose) polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders
    • Hassa PO, Hottiger MO: The functional role of poly (ADP -ribose) polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci, 2002; 59: 1534-1553
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1534-1553
    • Hassa, P.O.1    Hottiger, M.O.2
  • 12
    • 1342327619 scopus 로고    scopus 로고
    • Transcription regulation of TNF-alpha-early response genes by poly (ADP -ribose) polymerase-1 in murine heart endothelial cells
    • Carrillo A, Monreal Y, Ramírez P, Marin L, Parrilla P, Oliver FJ, Yélamous J: Transcription regulation of TNF-alpha-early response genes by poly (ADP -ribose) polymerase-1 in murine heart endothelial cells. Nucleic Acids Res, 2004; 32: 757-766
    • (2004) Nucleic Acids Res , vol.32 , pp. 757-766
    • Carrillo, A.1    Monreal, Y.2    Ramírez, P.3    Marin, L.4    Parrilla, P.5    Oliver, F.J.6    Yélamous, J.7
  • 13
    • 0037387772 scopus 로고    scopus 로고
    • Poly (ADP -ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: Implication for neurodegenerative disorders
    • Chiarugi A, Moskowitz MA: Poly (ADP -ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J Neurochem, 2003; 85: 306-317
    • (2003) J Neurochem , vol.85 , pp. 306-317
    • Chiarugi, A.1    Moskowitz, M.A.2
  • 14
    • 0345628001 scopus 로고    scopus 로고
    • Inhibition of ADP -ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
    • Le Page C, Sanceau J, Drapier JC, Wietzerbin J: Inhibition of ADP -ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation. Biochem Biophys Res Commum, 1998; 243: 451-457
    • (1998) Biochem Biophys Res Commum , vol.243 , pp. 451-457
    • Le Page, C.1    Sanceau, J.2    Drapier, J.C.3    Wietzerbin, J.4
  • 16
    • 0037143598 scopus 로고    scopus 로고
    • Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques
    • Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM: Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation, 2002; 106: 927-932
    • (2002) Circulation , vol.106 , pp. 927-932
    • Martinet, W.1    Knaapen, M.W.2    De Meyer, G.R.3    Herman, A.G.4    Kockx, M.M.5
  • 17
    • 34248178529 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibition reduces athero-sclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: Effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death
    • Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, Fallon K, Woods C, Boulares AH: Poly (ADP-ribose) polymerase inhibition reduces athero-sclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation, 2007; 115: 2442-2450
    • (2007) Circulation , vol.115 , pp. 2442-2450
    • Oumouna-Benachour, K.1    Hans, C.P.2    Suzuki, Y.3    Naura, A.4    Datta, R.5    Belmadani, S.6    Fallon, K.7    Woods, C.8    Boulares, A.H.9
  • 19
    • 0037137305 scopus 로고    scopus 로고
    • Antimonocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice
    • Inoue S, Egashira K, Ni W, Kitamoto S, Usui M, Otani K, Ishibashi M, Hiasa K, Nishida K, Takeshita A: Antimonocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice. Circulation, 2002;106: 2700-2706
    • (2002) Circulation , vol.106 , pp. 2700-2706
    • Inoue, S.1    Egashira, K.2    Ni, W.3    Kitamoto, S.4    Usui, M.5    Otani, K.6    Ishibashi, M.7    Hiasa, K.8    Nishida, K.9    Takeshita, A.10
  • 23
    • 0036884292 scopus 로고    scopus 로고
    • A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants
    • Schubert SY, Neeman I, Resnick N: A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J, 2002; 16: 1931-1933
    • (2002) FASEB J , vol.16 , pp. 1931-1933
    • Schubert, S.Y.1    Neeman, I.2    Resnick, N.3
  • 24
    • 33747262660 scopus 로고    scopus 로고
    • Homocysteine stimulates phosphorylation of NAPDH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation
    • Siow YL, Au-Yeung KK, Woo CW, O K: Homocysteine stimulates phosphorylation of NAPDH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation. Biochem J, 2006; 398: 73-82
    • (2006) Biochem J , vol.398 , pp. 73-82
    • Siow, Y.L.1    Au-Yeung, K.K.2    Woo3    CW, O.K.4
  • 25
    • 4444367705 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibition prevents homocysteine-induced endothelial dysfunction in the isolated rat aorta
    • Tasatargil A, Dalaklioglu S, Sadan G: Poly (ADP-ribose) polymerase inhibition prevents homocysteine-induced endothelial dysfunction in the isolated rat aorta. Pharmacology, 2004; 72: 99-105
    • (2004) Pharmacology , vol.72 , pp. 99-105
    • Tasatargil, A.1    Dalaklioglu, S.2    Sadan, G.3
  • 26
    • 0038648686 scopus 로고    scopus 로고
    • Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity
    • Joshi SG, Francis CW, Silverman DJ, Sahni SK: Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun, 2003; 71: 4127-4136
    • (2003) Infect Immun , vol.71 , pp. 4127-4136
    • Joshi, S.G.1    Francis, C.W.2    Silverman, D.J.3    Sahni, S.K.4
  • 27
    • 0035573652 scopus 로고    scopus 로고
    • Dietary supplementation with menthionine and homocysteine promotes early athrosclerosis but not plaque rupture in ApoE-deficient mice
    • Zhou J, Møller J, Danielsen CC, Bentzon J, Ravn HB, Austin RC, Falk E: Dietary supplementation with menthionine and homocysteine promotes early athrosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler Thromb Vasc Biol, 2001; 21: 1470-1476
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1470-1476
    • Zhou, J.1    Møller, J.2    Danielsen, C.C.3    Bentzon, J.4    Ravn, H.B.5    Austin, R.C.6    Falk, E.7
  • 28
    • 0037497965 scopus 로고    scopus 로고
    • Effect of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice
    • Zhou J, Møller J, Ritskes-Hoitinga M, Larsen ML, Austin RC, Falk E: Effect of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice. Atheroscletosis, 2003; 168: 255-262
    • (2003) Atheroscletosis , vol.168 , pp. 255-262
    • Zhou, J.1    Møller, J.2    Ritskes-Hoitinga, M.3    Larsen, M.L.4    Austin, R.C.5    Falk, E.6
  • 29
    • 0037926903 scopus 로고    scopus 로고
    • Hyperhomocysteinemia accelerates atherosclerosis in cystathiorine beta-synthase and apolipoprotein E double knock-out mice with and without dietary pertyrbation
    • Wang H, Jiang X, Yang F, Gaubatz JW, Ma L, Magera MJ, Yang X, Berger PB, Durante W, Pownall HJ, Schafer AI: Hyperhomocysteinemia accelerates atherosclerosis in cystathiorine beta-synthase and apolipoprotein E double knock-out mice with and without dietary pertyrbation. Blood, 2003; 101: 3901-3907
    • (2003) Blood , vol.101 , pp. 3901-3907
    • Wang, H.1    Jiang, X.2    Yang, F.3    Gaubatz, J.W.4    Ma, L.5    Magera, M.J.6    Yang, X.7    Berger, P.B.8    Durante, W.9    Pownall, H.J.10    Schafer, A.I.11
  • 31
    • 0024536929 scopus 로고
    • Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease
    • Werns SW, Walton JA, Hsia HH, Nabel EG, Sanz ML, Pitt B: Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation, 1989; 79: 287-291
    • (1989) Circulation , vol.79 , pp. 287-291
    • Werns, S.W.1    Walton, J.A.2    Hsia, H.H.3    Nabel, E.G.4    Sanz, M.L.5    Pitt, B.6
  • 32
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
    • Starkebaum G, Harlan JM: Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest, 1986; 77: 1370-1376
    • (1986) J Clin Invest , vol.77 , pp. 1370-1376
    • Starkebaum, G.1    Harlan, J.M.2
  • 33
    • 0032127666 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
    • Szabó C, Dawson VL: Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci, 1998; 19: 287-298
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 287-298
    • Szabó, C.1    Dawson, V.L.2
  • 35
    • 0036215470 scopus 로고    scopus 로고
    • Endothelial dysfunction in aging animals: The role of Poly (ADP-ribose) polymerase activation
    • Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjáti K, Szabó C: Endothelial dysfunction in aging animals: The role of Poly (ADP-ribose) polymerase activation. Br J Pharmacol, 2002; 135: 1347-1350
    • (2002) Br J Pharmacol , vol.135 , pp. 1347-1350
    • Pacher, P.1    Mabley, J.G.2    Soriano, F.G.3    Liaudet, L.4    Komjáti, K.5    Szabó, C.6
  • 36
    • 0035851210 scopus 로고    scopus 로고
    • Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of Poly (ADP-ribose) polymerase
    • Soriano FG, Pacher P, Mabley J, Liaudet L, Szabó C: Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of Poly (ADP-ribose) polymerase. Circ Res, 2001; 89: 684-691
    • (2001) Circ Res , vol.89 , pp. 684-691
    • Soriano, F.G.1    Pacher, P.2    Mabley, J.3    Liaudet, L.4    Szabó, C.5
  • 37
    • 0031281259 scopus 로고    scopus 로고
    • Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of Poly (ADP-ribose) synthetase
    • Zingarelli B, Cuzzocrea S, Zsengellér Z, Salzman AL, Szabó C: Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of Poly (ADP-ribose) synthetase. Cardiovasc Res, 1997; 36: 205-215
    • (1997) Cardiovasc Res , vol.36 , pp. 205-215
    • Zingarelli, B.1    Cuzzocrea, S.2    Zsengellér, Z.3    Salzman, A.L.4    Szabó, C.5
  • 38
  • 39
    • 0347951237 scopus 로고    scopus 로고
    • Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress
    • Au-Yeung KK, Woo CW, Sung FL, Yip JC, Siow YL, O K: Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress. Circ Res, 2004; 94: 28-36
    • (2004) Circ Res , vol.94 , pp. 28-36
    • Au-Yeung, K.K.1    Woo, C.W.2    Sung, F.L.3    Yip, J.C.4    Siow5    YL, O.K.6
  • 40
    • 8744234076 scopus 로고    scopus 로고
    • Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
    • Shishodia S, Aggarwal BB: Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem, 2004; 279: 47148-47158
    • (2004) J Biol Chem , vol.279 , pp. 47148-47158
    • Shishodia, S.1    Aggarwal, B.B.2
  • 41
    • 0033198919 scopus 로고    scopus 로고
    • Poly (ADP-ribosyl) ation reactions in the regulation of nuclear functions
    • D'Amours D, Desnoyers S, D'Silva I, Poirier GG: Poly (ADP-ribosyl) ation reactions in the regulation of nuclear functions. Biochem J, 1999; 342: 249-268
    • (1999) Biochem J , vol.342 , pp. 249-268
    • D'Amours, D.1    Desnoyers, S.2    D'Silva, I.3    Poirier, G.G.4
  • 42
    • 0036499892 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase: Killer or conspirator? The 'suicide hypothesis' revisited
    • Chiarugi A: Poly (ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci, 2002; 23: 122-129
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 122-129
    • Chiarugi, A.1
  • 43
    • 0035824647 scopus 로고    scopus 로고
    • The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function
    • Hassa PO, Covic M, Hasan S, Imbof R, Hottiger MO: The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function. J Biol Chem, 2001; 276: 45588-45597
    • (2001) J Biol Chem , vol.276 , pp. 45588-45597
    • Hassa, P.O.1    Covic, M.2    Hasan, S.3    Imbof, R.4    Hottiger, M.O.5
  • 44
    • 0142240271 scopus 로고    scopus 로고
    • Absence of Poly (ADP-ribose) poly-merase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury
    • Zingarelli B, Hake PW, O'Connor M, Denenberg A, Kong S, Aronow BJ: Absence of Poly (ADP-ribose) poly-merase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury. Mol Med, 2003; 9: 143-153
    • (2003) Mol Med , vol.9 , pp. 143-153
    • Zingarelli, B.1    Hake, P.W.2    O'Connor, M.3    Denenberg, A.4    Kong, S.5    Aronow, B.J.6
  • 45
    • 0035844038 scopus 로고    scopus 로고
    • Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells
    • Huang RF, Huang SM, Lin BS, Wei JS, Liu TZ: Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells. Life Sci, 2001; 68: 2799-2811
    • (2001) Life Sci , vol.68 , pp. 2799-2811
    • Huang, R.F.1    Huang, S.M.2    Lin, B.S.3    Wei, J.S.4    Liu, T.Z.5
  • 46
    • 0028102478 scopus 로고
    • Cleavage of Poly (ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earushaw WC: Cleavage of Poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature, 1994; 371: 346-347
    • (1994) Nature , vol.371 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earushaw, W.C.5
  • 47
    • 0029022554 scopus 로고
    • Apoptosis in human atherosclerosis and restenosis
    • Isner JM, Kearney M, Bortman S, Passeri J: Apoptosis in human atherosclerosis and restenosis. Circulation, 1995; 91: 2703-2711
    • (1995) Circulation , vol.91 , pp. 2703-2711
    • Isner, J.M.1    Kearney, M.2    Bortman, S.3    Passeri, J.4
  • 48
    • 0030034534 scopus 로고    scopus 로고
    • Distribution of cell replication and apoptosis in atherosclerotic plaques of cholesterol-fed rabbits
    • Kockx MM, De Meyer GR, Muhring J, Bult H, Bultinck J, Herman AG: Distribution of cell replication and apoptosis in atherosclerotic plaques of cholesterol-fed rabbits. Atherosclerosis, 1996; 120: 115-124
    • (1996) Atherosclerosis , vol.120 , pp. 115-124
    • Kockx, M.M.1    De Meyer, G.R.2    Muhring, J.3    Bult, H.4    Bultinck, J.5    Herman, A.G.6
  • 49
    • 0030474490 scopus 로고    scopus 로고
    • Foam cell apoptosis and the development of the lipid core of human atherosclerosis
    • Hegyi L, Skepper JN, Cary NR, Mitchinson MJ: Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J Pathol, 1996; 180: 423-429
    • (1996) J Pathol , vol.180 , pp. 423-429
    • Hegyi, L.1    Skepper, J.N.2    Cary, N.R.3    Mitchinson, M.J.4
  • 52
    • 0030000690 scopus 로고    scopus 로고
    • DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
    • Szabó C, Zingarelli B, O'Connor M, Salzman AL: DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA, 1996; 93: 1753-1758
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1753-1758
    • Szabó, C.1    Zingarelli, B.2    O'Connor, M.3    Salzman, A.L.4


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