The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

Journal of Molecular Biology

Volumn 395, Issue 2, 2010, Pages 390-407

  Gómez García, Inmaculada ^a   Stevenson, Clare E M ^a   Usón, Isabel ^b   Freel Meyers, Caren L ^c   Walsh, Christopher T ^c   Lawson, David M ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

crystal structure; novobiocin; O methyltransferase; Streptomyces spheroides; TylF superfamily

Indexed keywords

ASPARTIC ACID; HOMODIMER; METHYLTRANSFERASE; NOVOBIOCIN; NOVOBIOCIN P; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; METAL BINDING; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN MODIFICATION; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STREPTOMYCES; STREPTOMYCES SPHEROIDES; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

STREPTOMYCES CAERULEUS;

EID: 73149115504     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.045     Document Type: Article

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