메뉴 건너뛰기




Volumn 28, Issue 5, 2009, Pages 448-456

Di (n-butyl) phthalate inhibits testosterone synthesis through a glucocorticoid-mediated pathway in rats

Author keywords

11 hydroxysteroid dehydrogenase; Di (n butyl) phthalate; Glucocorticoids; Glucocorticoids receptor; Testosterone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PHTHALIC ACID DIBUTYL ESTER; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

EID: 73149091025     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809342596     Document Type: Article
Times cited : (27)

References (22)
  • 1
    • 0034175757 scopus 로고    scopus 로고
    • Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: Implications for human risk assessment
    • Foster PM, Cattley RC, Mylchreest E. Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. Food Chem Toxicol. 2000; 38:97-99.
    • (2000) Food Chem Toxicol. , vol.38 , pp. 97-99
    • Foster, P.M.1    Cattley, R.C.2    Mylchreest, E.3
  • 2
    • 0033668245 scopus 로고    scopus 로고
    • Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers
    • Loff S, Kabs F, Witt K, et al. Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. J Pediatr Surg. 2000;35:1775-1781.
    • (2000) J Pediatr Surg. , vol.35 , pp. 1775-1781
    • Loff, S.1    Kabs, F.2    Witt, K.3
  • 3
    • 0035153953 scopus 로고    scopus 로고
    • Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review
    • Tickner JA, Schettler T, Guidotti T, McCally M, Rossi M. Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. Am J Ind Med. 2001;39: 100-111.
    • (2001) Am J Ind Med. , vol.39 , pp. 100-111
    • Tickner, J.A.1    Schettler, T.2    Guidotti, T.3    McCally, M.4    Rossi, M.5
  • 4
    • 0034282493 scopus 로고    scopus 로고
    • Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS
    • Blount BC, Milgram KE, Silva MJ, et al. Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS. Anal Chem. 2000;72:4127-4134.
    • (2000) Anal Chem. , vol.72 , pp. 4127-4134
    • Blount, B.C.1    Milgram, K.E.2    Silva, M.J.3
  • 6
    • 0035194978 scopus 로고    scopus 로고
    • Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    • Shultz VD, Phillips S, Sar M, Foster PM, Gaido KW. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol Sci. 2001;64: 233-242.
    • (2001) Toxicol Sci. , vol.64 , pp. 233-242
    • Shultz, V.D.1    Phillips, S.2    Sar, M.3    Foster, P.M.4    Gaido, K.W.5
  • 8
    • 23944487083 scopus 로고    scopus 로고
    • Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses
    • Wyde ME, Kirwan SE, Zhang F, et al. Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses. Toxicol Sci. 2005;86:281-290.
    • (2005) Toxicol Sci. , vol.86 , pp. 281-290
    • Wyde, M.E.1    Kirwan, S.E.2    Zhang, F.3
  • 9
    • 33751241130 scopus 로고    scopus 로고
    • Acute and longterm effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation
    • Ferrara D, Hallmark N, Scott H, et al. Acute and longterm effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation. Endocrine. 2006;147: 5352-5362.
    • (2006) Endocrine. , vol.147 , pp. 5352-5362
    • Ferrara, D.1    Hallmark, N.2    Scott, H.3
  • 10
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • DOI 10.1093/humupd/7.3.231
    • Foster PM, Mylchreest E, Gaido KW, Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update. 2001;7:231-235. (Pubitemid 32440285)
    • (2001) Human Reproduction Update , vol.7 , Issue.3 , pp. 231-235
    • Foster, P.M.D.1    Mylchreest, E.2    Gaido, K.W.3    Sar, M.4
  • 11
    • 33845407653 scopus 로고    scopus 로고
    • Estrogenic activity of phthalate esters by in vitro VTG assay using primary-cultured Xenopus hepatocytes
    • Nomura Y, Mitsui N, Bhawal UK, et al. Estrogenic activity of phthalate esters by in vitro VTG assay using primary-cultured Xenopus hepatocytes. Dental Materials J. 2006;25:533-537.
    • (2006) Dental Materials J. , vol.25 , pp. 533-537
    • Nomura, Y.1    Mitsui, N.2    Bhawal, U.K.3
  • 12
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks LG, Ostby JS, Lambright CR, et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci. 2000;58: 339-349.
    • (2000) Toxicol Sci. , vol.58 , pp. 339-349
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3
  • 13
    • 0037497143 scopus 로고    scopus 로고
    • Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate
    • Barlow NJ, Phillips SL, Wallace DG, Sar M, Gaido KW, Foster PM. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci. 2003;73:431-441.
    • (2003) Toxicol Sci. , vol.73 , pp. 431-441
    • Barlow, N.J.1    Phillips, S.L.2    Wallace, D.G.3    Sar, M.4    Gaido, K.W.5    Foster, P.M.6
  • 14
    • 0036010069 scopus 로고    scopus 로고
    • Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    • Mylchreest E, Sar M, Wallace DG, Foster PM. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol. 2002;16:19-28.
    • (2002) Reprod Toxicol. , vol.16 , pp. 19-28
    • Mylchreest, E.1    Sar, M.2    Wallace, D.G.3    Foster, P.M.4
  • 15
    • 33745504602 scopus 로고    scopus 로고
    • Age-specific effect of phthalate ester on testicular development in rats
    • Kondo T, Shono T, Suita S. Age-specific effect of phthalate ester on testicular development in rats. J Pediatr Surg. 2006;41: 1290-1293.
    • (2006) J Pediatr Surg. , vol.41 , pp. 1290-1293
    • Kondo, T.1    Shono, T.2    Suita, S.3
  • 16
    • 3042577511 scopus 로고    scopus 로고
    • Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL
    • Zhang Y, Jiang X, Chen B. Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. Reprod Toxicol. 2004;18: 669-676.
    • (2004) Reprod Toxicol. , vol.18 , pp. 669-676
    • Zhang, Y.1    Jiang, X.2    Chen, B.3
  • 17
    • 34147163038 scopus 로고    scopus 로고
    • Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: Comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human
    • Hallmark N, Walker M, McKinnell C, et al. Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect. 2007;115: 390-396.
    • (2007) Environ Health Perspect. , vol.115 , pp. 390-396
    • Hallmark, N.1    Walker, M.2    McKinnell, C.3
  • 18
    • 0034820849 scopus 로고    scopus 로고
    • Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?
    • Gass P, Reichardt HM, Strekalova T, Henn F, Tronche F. Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety? Physiol Behav. 2001;73:811-825.
    • (2001) Physiol Behav. , vol.73 , pp. 811-825
    • Gass, P.1    Reichardt, H.M.2    Strekalova, T.3    Henn, F.4    Tronche, F.5
  • 19
    • 4444319484 scopus 로고    scopus 로고
    • Immunomodulatory activities of glucocorticoids: Insights from transgenesis and gene targeting
    • Reichardt HM. Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targeting. Curr Pharmacol Design. 2004;10:2797-2805.
    • (2004) Curr Pharmacol Design. , vol.10 , pp. 2797-2805
    • Reichardt, H.M.1
  • 20
    • 2442473541 scopus 로고    scopus 로고
    • Differential expression of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development
    • Thompson A, Han VK, Yang K. Differential expression of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J Steroid Biochem Mol Biol. 2004;88:367-375.
    • (2004) J Steroid Biochem Mol Biol. , vol.88 , pp. 367-375
    • Thompson, A.1    Han, V.K.2    Yang, K.3
  • 21
    • 27944503010 scopus 로고    scopus 로고
    • Stress hormone and male reproductive function
    • Hardy MP, Gao HB, Dong Q, et al. Stress hormone and male reproductive function. Cell Tissue Res. 2005;322: 147-153.
    • (2005) Cell Tissue Res. , vol.322 , pp. 147-153
    • Hardy, M.P.1    Gao, H.B.2    Dong, Q.3
  • 22
    • 44649201559 scopus 로고    scopus 로고
    • Rapid mechanisms of glucocorticoid signaling in the Leydig cell
    • Hu GX, Lian QQ, Lin H, et al. Rapid mechanisms of glucocorticoid signaling in the Leydig cell. Steroids. 2008;73:1018-1024.
    • (2008) Steroids. , vol.73 , pp. 1018-1024
    • Hu, G.X.1    Lian, Q.Q.2    Lin, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.