Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo

Toxicological Sciences

Volumn 90, Issue 1, 2006, Pages 96-110

  Diani Moore, Silvia ^a   Labitzke, Erin ^a   Brown, Richard ^a   Garvin, Alexander ^a   Wong, Linda ^a   Rifkind, Arleen B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Arachidonic acid epoxygenation; Chick embryo; CYP1A4; CYP1A5; Dioxin; Sunlight; Tryptophan photooxidation

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ARACHIDONIC ACID; AROMATIC HYDROCARBON RECEPTOR; CARBAZOLE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1A4; CYTOCHROME P450 1A5; ETHOXYRESORUFIN DEETHYLASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER MICROSOME METABOLISM; NONHUMAN; PHOTOACTIVATION; PHOTOOXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN FUNCTION; RECEPTOR BINDING; SUNLIGHT; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ARACHIDONIC ACID; ARYL HYDROCARBON HYDROXYLASES; AVIAN PROTEINS; CARBAZOLES; CELLS, CULTURED; CHICK EMBRYO; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; INDOLES; LIVER; OXIDATION-REDUCTION; OXIDOREDUCTASES; PHOTOLYSIS; PHOTOSENSITIZING AGENTS; RNA, MESSENGER; SUNLIGHT; TRYPTOPHAN;

ANIMALIA; MAMMALIA;

EID: 33144477599     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfj065     Document Type: Article

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