The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6975-6983

  Jeon, M S ^a   Esser, C ^a  

^a Med Inst of Environmental Hygiene   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; COMPLEMENTARY DNA; CYTOKINE; DNA; INTERLEUKIN 1BETA; INTERLEUKIN 2; MESSENGER RNA; RNA; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

EID: 0034671615     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6975     Document Type: Article

References (50)

1. Transcriptional regulation of the IL-2 gene
2. Regulatory anatomy of the murine interleukin-2 gene
3. cDNA cloning and structure of mouse putative Ah receptor
4. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
5. Control of cell lineage-specific development and transcription by bHLH-PAS proteins
6. 2+-mediated endonuclease activation
7. Role of Fas apoptosis and MHC genes in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity of T cells
8. Role of the Ah receptor and dioxin inducible (Ah) gene battery in toxicity, cancer, and signal transduction
9. Carcinogenicity of TCDD experimental, mechanistic, and epidemiologic evidence
10. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
11. Identification of dioxin-responsive elements (DREs) in the 5' regions of putative dioxin-inducible genes
12. Control of cytochrome P1-450 gene expression analysis of a dioxin-responsive enhancer system
13. A DNA-binding factor specific for xenobiotic responsive elements of P-450 gene exists as a cryptic form in cytoplasm its possible translocation to nucleus
14. Protein-DNA interactions at a dioxin-responsive enhancer analysis of six bona fide DNA-binding sites for the liganded Ah receptor
15. Cytokine gene expression during ontogeny in murine thymus on activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin
16. 2,3,7,8-Terachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-α and -β2 expression in a human keratinocyte cell line revolves both transcriptional and post-transcriptional control
17. Interleukin-2 inception, impact, and implications
18. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
19. Morphologic and antigenic maturation of lymphocytes in the mouse thymus in vitro
20. Applications of fetal thymus organ cultures in studies of T cell development
21. Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotic fails to support proliferation of early thymocytes but reduces differentiation
22. Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene
23. Monitoring mRNA expression by polymerase chain reaction the 'primer-dropping' method
24. + cells
25. 2,3,7,8-Tetrachlorodibenzo-p-dixon receptors in wild type and variant mouse hepatoma cells nuclear location and strength of nuclear binding
26. 2+ requirement
27. Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxi-inducible CYP1A1 expression in human breast carcinoma cell lines revolve altered trans-acting factors
28. Specific protein-DNA interactions at a xenobiotic-responsive element co-purification of dioxin receptor and DNA-binding activity
29. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
30. Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways
31. 2,3,7,8-Tetrachlorodibenzo-p-dioxin co-stimulates staphylococcal enterotoxin β (SEB) cytokine production and phenotypic cell cycling in Long-Evans rats
32. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin
33. Molecular basis for developmental changes in interleukin-2 gene reducibility
34. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells
35. T cell reactivation linked to Ras block
36. Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity
37. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
38. The Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in human leukemic T cell lines
39. Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat
40. Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex
41. Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene
42. Identification of multiple regulatory elements on the human cytochrome P4501A1 gene
43. Chromatin remodeling of the interleukin-2 gene distract alterations in the proximal versus distal enhancer regions
44. Aryl hydrocarbon receptor-mediated signal transduction
45. Interleukin 2 and its receptors recent advances and new immunological functions
46. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
47. Development of fetal thymocytes in organ cultures effect of interleukin 2
48. The effects of interleukin 2 on early and late thymocyte differentiation in foetal thymus organ culture
49. Modulation of T-cell differentiation in murine fetal thymus organ cultures