Exercise and Bipolar Disorder: A Review of Neurobiological Mediators

NeuroMolecular Medicine

Volumn 11, Issue 4, 2009, Pages 328-336

  Alsuwaidan, Mohammad T ^a,c   Kucyi, Aaron ^d   Law, Candy W Y ^c   McIntyre, Roger S ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d YORK UNIVERSITY   (Canada)

Author keywords

Bipolar disorder; Cognition; Exercise

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 HYDROXYINDOLEACETIC ACID; ANANDAMIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID 1 RECEPTOR; CYTOKINE; DOPAMINE; ENDOCANNABINOID; HOMOVANILLIC ACID; LITHIUM; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN; PHENETHYLAMINE; PHENYLACETIC ACID; REACTIVE OXYGEN METABOLITE; SELEGILINE; SEROTONIN; SOMATOMEDIN; TRYPTOPHAN; VALPROIC ACID;

5 HYDROXYINDOLEACETIC ACID BRAIN LEVEL; ARTICLE; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BRAIN; CELL RESPIRATION; CELL SURVIVAL; CEREBROSPINAL FLUID; COGNITION; COGNITIVE DEFECT; DEPRESSION; DISEASE SEVERITY; DOPAMINERGIC SYSTEM; ELECTRON TRANSPORT; EXERCISE; EXPERIMENTAL STUDY; HEALTH; HUMAN; IMMUNOREACTIVITY; INTERVENTION STUDY; LANGUAGE; MAJOR DEPRESSION; MEDICAL LITERATURE; MEDLINE; METABOLISM; MOOD DISORDER; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROBIOLOGY; NEUROIMAGING; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; NORADRENERGIC SYSTEM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PLEIOTROPY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUBLIC HEALTH; PUBLICATION; RESPIRATORY CHAIN; SAMPLE; SAMPLE SIZE; SEROTONINERGIC SYSTEM; TRYPTOPHAN BRAIN LEVEL; VALIDATION PROCESS;

ANIMALS; BIPOLAR DISORDER; ENDOCANNABINOIDS; EXERCISE; EXERCISE THERAPY; HUMANS; MICE; NEURONAL PLASTICITY; NEUROTRANSMITTER AGENTS; OXIDATIVE STRESS; RATS;

EID: 72949111351     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-009-8079-9     Document Type: Article

References (101)

1. HM Alessio AH Goldfarb 1988 Lipid peroxidation and scavenger enzymes during exercise: Adaptive response to training Journal of Applied Physiology 64 1333 1336 1:CAS:528:DyaL1cXitF2mtrg%3D 3378967
2. CH Ashton PB Moore P Gallagher AH Young 2005 Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential Journal of Psychopharmacology (Oxford, England) 19 293 300 10.1177/ 0269881105051541 1:CAS:528:DC%2BD2MXltlWju7w%3D (Pubitemid 40694948)
3. KA Barbour TM Edenfield JA Blumenthal 2007 Exercise as a treatment for depression and other psychiatric disorders: A review Journal of Cardiopulmonary Rehabilitation and Prevention 27 359 367 18197069
4. RH Belmaker 2004 Bipolar disorder The New England Journal of Medicine 351 476 486 10.1056/NEJMra035354 1:CAS:528:DC%2BD2cXmtFakt7s%3D 15282355 (Pubitemid 38988597)
5. NC Berchtold G Chinn M Chou JP Kesslak CW Cotman 2005 Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus Neuroscience 133 853 861 10.1016/j.neuroscience.2005.03.026 1:CAS:528:DC%2BD2MXltFWisLo%3D 15896913 (Pubitemid 40798336)
6. M Bidaut-Russell WA Devane AC Howlett 1990 Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain Journal of Neurochemistry 55 21 26 10.1111/j.1471-4159.1990.tb08815.x 1:CAS:528:DyaK3cXkslWitbs%3D 2162376 (Pubitemid 20187799)
7. JE Black KR Isaacs BJ Anderson AA Alcantara WT Greenough 1990 Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats Proceedings of the National Academy of Sciences of the United States of America 87 5568 5572 10.1073/pnas.87.14.5568 1:STN:280:DyaK3czhvFWmsQ%3D%3D 1695380 (Pubitemid 20260222)
8. L Capuron AH Miller 2004 Cytokines and psychopathology: Lessons from interferon-alpha Biological Psychiatry 56 819 824 10.1016/j.biopsych.2004.02.009 1:CAS:528:DC%2BD2cXhtVCktL7N 15576057 (Pubitemid 39575454)
9. MH Chan AL Carey MJ Watt MA Febbraio 2004 Cytokine gene expression in human skeletal muscle during concentric contraction: Evidence that IL-8, like IL-6, is influenced by glycogen availability American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 287 R322 R327 1:CAS:528:DC%2BD2cXmvFaktLk%3D 15072962
10. F Chaouloff JL Elghozi Y Guezennec D Laude 1985 Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat British Journal of Pharmacology 86 33 41 1:CAS:528:DyaL2MXlvFSnsrk%3D 2413941
11. F Chaouloff D Laude Y Guezennec JL Elghozi 1986 Motor activity increases tryptophan, 5-hydroxyindoleacetic acid, and homovanillic acid in ventricular cerebrospinal fluid of the conscious rat Journal of Neurochemistry 46 1313 1316 10.1111/j.1471-4159.1986.tb00656.x 1:CAS:528:DyaL28Xhs1ant7k%3D 2419509
12. S Colcombe AF Kramer 2003 Fitness effects on the cognitive function of older adults: A meta-analytic study Psychological Science 14 125 130 10.1111/1467-9280.t01-1-01430 12661673 (Pubitemid 37283096)
13. M Collino M Aragno R Mastrocola M Gallicchio AC Rosa C Dianzani O Danni C Thiemermann R Fantozzi 2006 Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion European Journal of Pharmacology 530 70 80 10.1016/j.ejphar.2005.11.049 1:CAS:528:DC%2BD28XhsFeqsw%3D%3D 16386242 (Pubitemid 43037126)
14. CW Cotman NC Berchtold 2002 Exercise: A behavioral intervention to enhance brain health and plasticity Trends in Neurosciences 25 295 301 10.1016/S0166-2236(02)02143-4 1:CAS:528:DC%2BD38Xks1ymtL8%3D 12086747 (Pubitemid 34667010)
15. CW Cotman NC Berchtold LA Christie 2007 Exercise builds brain health: Key roles of growth factor cascades and inflammation Trends in Neurosciences 30 464 472 10.1016/j.tins.2007.06.011 1:CAS:528:DC%2BD2sXhtVClsrrK 17765329 (Pubitemid 47374831)
16. KJ Davies AT Quintanilha GA Brooks L Packer 1982 Free radicals and tissue damage produced by exercise Biochemical and Biophysical Research Communications 107 1198 1205 10.1016/S0006-291X(82)80124-1 1:CAS:528:DyaL38Xlt1Gjsrw%3D 6291524 (Pubitemid 13222413)
17. MO Dietrich ZB Andrews TL Horvath 2008 Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation Journal of Neuroscience 28 10766 10771 10.1523/JNEUROSCI.2744-08.2008 1:CAS:528:DC%2BD1cXht1ymt7nN 18923051
18. A Dietrich WF McDaniel 2004 Endocannabinoids and exercise British Journal of Sports Medicine 38 536 541 10.1136/bjsm.2004.011718 1:STN:280: DC%2BD2cvns1Ghsg%3D%3D 15388533 (Pubitemid 39319200)
19. YH Ding J Li Y Zhou JA Rafols JC Clark Y Ding 2006 Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise Current Neurovascular Research 3 15 23 10.2174/156720206775541787 1:CAS:528: DC%2BD28Xms12lsLo%3D 16472122
20. RK Dishman KJ Renner SD Youngstedt TG Reigle BN Bunnell KA Burke HS Yoo EH Mougey JL Meyerhoff 1997 Activity wheel running reduces escape latency and alters brain monoamine levels after footshock Brain Research Bulletin 42 399 406 10.1016/S0361-9230(96)00329-2 1:CAS:528:DyaK2sXislGnsL4%3D 9092882 (Pubitemid 27161558)
21. WC Drevets E Frank JC Price DJ Kupfer D Holt PJ Greer Y Huang C Gautier C Mathis 1999 PET imaging of serotonin 1A receptor binding in depression Biological Psychiatry 46 1375 1387 10.1016/S0006-3223(99)00189-4 1:CAS:528:DyaK1MXntlensrs%3D 10578452
22. RS Duman 2002 Synaptic plasticity and mood disorders Molecular Psychiatry 7 Suppl 1 S29 S34 10.1038/sj.mp.4001016 1:CAS:528:DC%2BD38XivFejs7w%3D 11986993
23. AL Dunn RK Dishman 1991 Exercise and the neurobiology of depression Exercise and Sport Sciences Reviews 19 41 98 10.1249/00003677-199101000-00002 1:STN:280:DyaK38%2FjslOktQ%3D%3D 1682151
24. BD Eadie VA Redila BR Christie 2005 Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density The Journal of Comparative Neurology 486 39 47 10.1002/cne.20493 15834963 (Pubitemid 40571648)
25. Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., et al. (2009). Neural mechanisms of a genome-wide supported psychosis variant. Science 324, 605.
26. K Fabel K Fabel B Tam D Kaufer A Baiker N Simmons CJ Kuo TD Palmer 2003 VEGF is necessary for exercise-induced adult hippocampal neurogenesis The European Journal of Neuroscience 18 2803 2812 10.1111/j.1460-9568.2003.03041.x 14656329 (Pubitemid 37542133)
27. J Farmer X Zhao H van Praag K Wodtke FH Gage BR Christie 2004 Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo Neuroscience 124 71 79 10.1016/j.neuroscience.2003.09.029 1:CAS:528:DC%2BD2cXhtFWitrw%3D 14960340 (Pubitemid 38186618)
28. MA Febbraio BK Pedersen 2002 Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles FASEB Journal 16 1335 1347 10.1096/fj.01-0876rev 1:CAS:528:DC%2BD38XntFWmt70%3D 12205025 (Pubitemid 34913306)
29. HC Fibiger 1991 Dopaminergic-cholinergic interactions in the striatum The Japanese Journal of Psychiatry and Neurology 45 512 1:STN:280: DyaK387gs1Kjtw%3D%3D 1662310
30. Goldstein, B. I., Kemp, D. E., Soczynska, J. K., McIntyre, R. S. (2009). Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: A systematic review of the literature. The Journal of Clinical Psychiatry [Epub ahead of print].
31. JJ Haddad NE Saade B Safieh-Garabedian 2002 Cytokines and neuro-immune-endocrine interactions: A role for the hypothalamic-pituitary- adrenal revolving axis Journal of Neuroimmunology 133 1 19 10.1016/S0165- 5728(02)00357-0 1:CAS:528:DC%2BD38Xoslantrs%3D 12446003 (Pubitemid 35346723)
32. P Heyn BC Abreu KJ Ottenbacher 2004 The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis Archives of Physical Medicine and Rehabilitation 85 1694 1704 10.1016/j.apmr.2004.03.019 15468033 (Pubitemid 39349417)
33. K Jakubs A Nanobashvili S Bonde CT Ekdahl Z Kokaia M Kokaia O Lindvall 2006 Environment matters: Synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability Neuron 52 1047 1059 10.1016/j.neuron.2006.11.004 1:CAS:528:DC%2BD2sXmsFajsw%3D%3D 17178407 (Pubitemid 44909404)
34. LL Judd HS Akiskal PJ Schettler J Endicott J Maser DA Solomon AC Leon JA Rice MB Keller 2002 The long-term natural history of the weekly symptomatic status of bipolar I disorder Archives of General Psychiatry 59 530 537 10.1001/archpsyc.59.6.530 12044195
35. YK Kim HG Jung AM Myint H Kim SH Park 2007 Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder Journal of Affective Disorders 104 91 95 10.1016/j.jad.2007.02.018 1:CAS:528: DC%2BD2sXht12ns7vN 17434599 (Pubitemid 350064526)
36. D Koethe IC Llenos JR Dulay C Hoyer EF Torrey FM Leweke S Weis 2007 Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression Journal of Neural Transmission 114 1055 1063 10.1007/s00702-007-0660-5 1:CAS:528: DC%2BD2sXotFWrtro%3D 17370106
37. F Lesperance N Frasure-Smith P Theroux M Irwin 2004 The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes The American Journal of Psychiatry 161 271 277 10.1176/appi.ajp.161.2. 271 14754776 (Pubitemid 38419278)
38. J Licinio ML Wong 1999 The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection Molecular Psychiatry 4 317 327 10.1038/sj.mp.4000586 1:CAS:528:DC%2BD3cXlvVWlu7k%3D 10483047
39. PJ Little BR Martin 1989 Cannabinoid modulation of cyclic AMP accumulation in synaptosomes NIDA Research Monograph 95 282 283 1:STN:280:DyaK3czkvVOktA%3D%3D 2561832
40. AD Lopez CC Murray 1998 The global burden of disease, 1990-2020 Nature Medicine 4 1241 1243 10.1038/3218 1:CAS:528:DyaK1cXntlantbk%3D 9809543 (Pubitemid 28512100)
41. M Maes HY Meltzer P D'Hondt P Cosyns P Blockx 1995 Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression Psychoneuroendocrinology 20 149 167 10.1016/0306-4530(94)00049-G 1:CAS:528:DyaK2MXivFSqsbo%3D 7899535 (Pubitemid 24366197)
42. JE Malberg AJ Eisch EJ Nestler RS Duman 2000 Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus Journal of Neuroscience 20 9104 9110 1:CAS:528:DC%2BD3MXis1SqsA%3D%3D 11124987
43. HK Manji G Chen 2002 PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers Molecular Psychiatry 7 Suppl 1 S46 S56 10.1038/sj.mp.4001018 1:CAS:528:DC%2BD38XivFejs7o%3D 11986995
44. HK Manji GJ Moore G Chen 2000 Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: A role for neurotrophic and neuroprotective effects in manic depressive illness The Journal of Clinical Psychiatry 61 Suppl 9 82 96 1:CAS:528:DC%2BD3cXktFKnu7c%3D 10826666
45. HK Manji WZ Potter RH Lenox 1995 Signal transduction pathways. Molecular targets for lithium's actions Archives of General Psychiatry 52 531 543 1:CAS:528:DyaK2MXnt1Oru7Y%3D 7598629
46. HK Manji JA Quiroz JL Payne J Singh BP Lopes JS Viegas CA Zarate 2003 The underlying neurobiology of bipolar disorder World Psychiatry 2 136 146 16946919
47. SJ Mathew K Keegan L Smith 2005 Glutamate modulators as novel interventions for mood disorders Revista Brasileira de Psiquiatria 27 243 248 10.1590/S1516-44462005000300016 16224615
48. MP Mattson T Magnus 2006 Ageing and neuronal vulnerability Nature Reviews 7 278 294 10.1038/nrn1886 1:CAS:528:DC%2BD28Xis1GksrY%3D 16552414
49. RS McIntyre JK Soczynska JZ Konarski HO Woldeyohannes CW Law A Miranda D Fulgosi SH Kennedy 2007 Should depressive syndromes be reclassified as "Metabolic Syndrome Type II"? Annals of Clinical Psychiatry 19 257 264 10.1080/10401230701653377 18058283 (Pubitemid 350208796)
50. R Meeusen K De Meirleir 1995 Exercise and brain neurotransmission Sports Medicine (Auckland, NZ) 20 160 188 10.2165/00007256-199520030-00004 1:STN:280:DyaK28%2Fptlemug%3D%3D
51. L Mestre F Correa A Arevalo-Martin E Molina-Holgado M Valenti G Ortar V Di Marzo C Guaza 2005 Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis Journal of Neurochemistry 92 1327 1339 10.1111/j.1471-4159.2004.02979.x 1:CAS:528:DC%2BD2MXislegsbg%3D 15748152 (Pubitemid 40389203)
52. MM Mesulam 1999 Neuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles Neuron 24 521 529 10.1016/S0896-6273(00) 81109-5 1:CAS:528:DyaK1MXnvFOqurY%3D 10595506
53. AR Newberg LA Catapano CA Zarate HK Manji 2008 Neurobiology of bipolar disorder Expert Review of Neurotherapeutics 8 93 110 10.1586/14737175.8.1.93 1:CAS:528:DC%2BD2sXhsVCgtb%2FP 18088203
54. AR Nielsen R Mounier P Plomgaard OH Mortensen M Penkowa T Speerschneider H Pilegaard BK Pedersen 2007 Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition The Journal of Physiology 584 305 312 10.1113/jphysiol.2007.139618 1:CAS:528:DC%2BD2sXhtFKrtbzP 17690139 (Pubitemid 47500557)
55. SM O'Brien P Scully LV Scott TG Dinan 2006 Cytokine profiles in bipolar affective disorder: Focus on acutely ill patients Journal of Affective Disorders 90 263 267 10.1016/j.jad.2005.11.015 16410025 (Pubitemid 43183536)
56. H Ogonovszky I Berkes S Kumagai T Kaneko S Tahara S Goto Z Radak 2005 The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain Neurochemistry International 46 635 640 10.1016/j.neuint.2005.02.009 1:CAS:528:DC%2BD2MXjs1Cnuro%3D 15863241 (Pubitemid 40614866)
57. SM Opal VA DePalo 2000 Anti-inflammatory cytokines Chest 117 1162 1172 10.1378/chest.117.4.1162 1:CAS:528:DC%2BD3cXjtFahsb0%3D 10767254
58. A Ortiz-Dominguez ME Hernandez C Berlanga D Gutierrez-Mora J Moreno G Heinze L Pavon 2007 Immune variations in bipolar disorder: Phasic differences Bipolar Disorders 9 596 602 10.1111/j.1399-5618.2007.00493.x 1:CAS:528:DC%2BD2sXht1aiu7jL 17845274 (Pubitemid 47365627)
59. G Pani R Colavitti B Bedogni R Anzevino S Borrello T Galeotti 2000 A redox signaling mechanism for density-dependent inhibition of cell growth The Journal of Biological Chemistry 275 38891 38899 10.1074/jbc.M007319200 1:CAS:528:DC%2BD3cXoslylsr4%3D 10988296 (Pubitemid 32010745)
60. BK Pedersen TC Akerstrom AR Nielsen CP Fischer 2007 Role of myokines in exercise and metabolism Journal of Applied Physiology 103 1093 1098 10.1152/japplphysiol.00080.2007 1:CAS:528:DC%2BD2sXhtFalsbjL 17347387 (Pubitemid 47358897)
61. RG Pertwee 2006 The pharmacology of cannabinoid receptors and their ligands: An overview International Journal of Obesity 30 Suppl 1 S13 S18 10.1038/sj.ijo.0803272 1:CAS:528:DC%2BD28XivFSmurw%3D 16570099
62. AM Petersen BK Pedersen 2005 The anti-inflammatory effect of exercise Journal of Applied Physiology 98 1154 1162 10.1152/japplphysiol.00164.2004 1:CAS:528:DC%2BD2MXjt1Wgsr8%3D 15772055 (Pubitemid 40396484)
63. ML Phillips WC Drevets SL Rauch R Lane 2003 Neurobiology of emotion perception II: Implications for major psychiatric disorders Biological Psychiatry 54 515 528 10.1016/S0006-3223(03)00171-9 12946880 (Pubitemid 37289438)
64. Z Radak HY Chung S Goto 2008 Systemic adaptation to oxidative challenge induced by regular exercise Free Radical Biology and Medicine 44 153 159 10.1016/j.freeradbiomed.2007.01.029 1:CAS:528:DC%2BD1cXlvVygtw%3D%3D 18191751
65. Z Radak T Kaneko S Tahara H Nakamoto J Pucsok M Sasvari C Nyakas S Goto 2001 Regular exercise improves cognitive function and decreases oxidative damage in rat brain Neurochemistry International 38 17 23 10.1016/S0197-0186(00)00063- 2 1:CAS:528:DC%2BD3cXnsVyls7o%3D 10913684 (Pubitemid 30407331)
66. Z Radak J Pucsok S Mecseki T Csont P Ferdinandy 1999 Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle Free Radical Biology and Medicine 26 1059 1063 10.1016/S0891-5849(98)00309-8 1:CAS:528:DyaK1MXislGktrs%3D 10232851 (Pubitemid 29198379)
67. Z Radak AW Taylor H Ohno S Goto 2001 Adaptation to exercise-induced oxidative stress: From muscle to brain Exercise Immunology Review 7 90 107 1:STN:280:DC%2BD3MrjtlKhsw%3D%3D 11579750
68. Z Radak A Toldy Z Szabo S Siamilis C Nyakas G Silye J Jakus S Goto 2006 The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain Neurochemistry International 49 387 392 10.1016/j.neuint.2006.02.004 1:CAS:528:DC%2BD28Xns1Smtrk%3D 16564605 (Pubitemid 44119045)
69. CL Raison L Capuron AH Miller 2006 Cytokines sing the blues: Inflammation and the pathogenesis of depression Trends in Immunology 27 24 31 10.1016/j.it.2005.11.006 1:CAS:528:DC%2BD28XmsVylsg%3D%3D 16316783 (Pubitemid 43083561)
70. MH Rhee Z Vogel J Barg M Bayewitch R Levy L Hanus A Breuer R Mechoulam 1997 Cannabinol derivatives: Binding to cannabinoid receptors and inhibition of adenylylcyclase Journal of Medicinal Chemistry 40 3228 3233 10.1021/jm970126f 1:CAS:528:DyaK2sXmtVehsLg%3D 9379442 (Pubitemid 27413747)
71. JD Richardson S Kilo KM Hargreaves 1998 Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors Pain 75 111 119 10.1016/S0304-3959(97)00213-3 1:CAS:528:DyaK1cXotlWjtg%3D%3D 9539680 (Pubitemid 28254862)
72. B Rouveix 1997 Clinical pharmacology of cytokines European Cytokine Network 8 291 293 1:CAS:528:DyaK2sXnsVKqsbk%3D 9346364
73. H Sabelli P Fink J Fawcett C Tom 1996 Sustained antidepressant effect of PEA replacement The Journal of Neuropsychiatry and Clinical Neurosciences 8 168 171 1:CAS:528:DyaK28XntFClsLs%3D 9081552
74. HC Sabelli JI Javaid 1995 Phenylethylamine modulation of affect: Therapeutic and diagnostic implications The Journal of Neuropsychiatry and Clinical Neurosciences 7 6 14 1:STN:280:DyaK2M3is12jsQ%3D%3D 7711493
75. AF Schatzberg JA Samson KL Bloomingdale PJ Orsulak B Gerson PP Kizuka JO Cole JJ Schildkraut 1989 Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders Archives of General Psychiatry 46 260 268 1:CAS:528:DyaK3MXksVOitbk%3D 2783211
76. E Schlicker M Kathmann 2001 Modulation of transmitter release via presynaptic cannabinoid receptors Trends in Pharmacological Sciences 22 565 572 10.1016/S0165-6147(00)01805-8 1:CAS:528:DC%2BD3MXotFSmsbk%3D 11698100 (Pubitemid 33042646)
77. C Schmidt-Hieber P Jonas J Bischofberger 2004 Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus Nature 429 184 187 10.1038/nature02553 1:CAS:528:DC%2BD2cXjvVKgsbk%3D 15107864 (Pubitemid 38656194)
78. S Sobczak A Honig NA Nicolson WJ Riedel 2002 Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controls Neuropsychopharmacology 27 834 842 10.1016/S0893-133X(02)00345-7 1:CAS:528:DC%2BD38Xoslyiurw%3D 12431857 (Pubitemid 35335899)
79. PB Sparling A Giuffrida D Piomelli L Rosskopf A Dietrich 2003 Exercise activates the endocannabinoid system NeuroReport 14 2209 2211 10.1097/00001756-200312020-00015 1:CAS:528:DC%2BD3sXptVCqurY%3D 14625449
80. A Steensberg CP Fischer C Keller K Moller BK Pedersen 2003 IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans American Journal of Physiology 285 E433 E437 1:CAS:528:DC%2BD3sXmsVahtr4%3D 12857678
81. SM Strakowski MP DelBello KW Sax ME Zimmerman PK Shear JM Hawkins ER Larson 1999 Brain magnetic resonance imaging of structural abnormalities in bipolar disorder Archives of General Psychiatry 56 254 260 10.1001/archpsyc.56. 3.254 1:STN:280:DyaK1M7ns1eruw%3D%3D 10078503
82. AM Stranahan D Khalil E Gould 2006 Social isolation delays the positive effects of running on adult neurogenesis Nature Neuroscience 9 526 533 10.1038/nn1668 1:CAS:528:DC%2BD28XivFSiur4%3D 16531997
83. D Sutoo K Akiyama 2003 Regulation of brain function by exercise Neurobiology of Disease 13 1 14 10.1016/S0969-9961(03)00030-5 1:CAS:528:DC%2BD3sXjvFWmtrs%3D 12758062 (Pubitemid 36564856)
84. A Szabo E Billett J Turner 2001 Phenylethylamine, a possible link to the antidepressant effects of exercise? British Journal of Sports Medicine 35 342 343 10.1136/bjsm.35.5.342 1:STN:280:DC%2BD3Mrjt1Sgsg%3D%3D 11579070 (Pubitemid 32929822)
85. J Thome N Sakai K Shin C Steffen YJ Zhang S Impey D Storm RS Duman 2000 cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment Journal of Neuroscience 20 4030 4036 1:CAS:528:DC%2BD3cXjsFeltbo%3D 10818138
86. H Tilg CA Dinarello JW Mier 1997 IL-6 and APPs: Anti-inflammatory and immunosuppressive mediators Immunology Today 18 428 432 10.1016/S0167-5699(97) 01103-1 1:CAS:528:DyaK2sXlvVGgsLk%3D 9293158 (Pubitemid 27381984)
87. A Toldy K Stadler M Sasvari J Jakus KJ Jung HY Chung I Berkes C Nyakas Z Radak 2005 The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain Brain Research Bulletin 65 487 493 10.1016/j.brainresbull.2005.02.028 1:CAS:528:DC%2BD2MXjvVKlsLs%3D 15862920 (Pubitemid 40615906)
88. JL Trejo E Carro I Torres-Aleman 2001 Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus Journal of Neuroscience 21 1628 1634 1:CAS:528: DC%2BD3MXjslClurs%3D 11222653
89. H van Praag BR Christie TJ Sejnowski FH Gage 1999 Running enhances neurogenesis, learning, and long-term potentiation in mice Proceedings of the National Academy of Sciences of the United States of America 96 13427 13431 10.1073/pnas.96.23.13427 10557337
90. H van Praag T Shubert C Zhao FH Gage 2005 Exercise enhances learning and hippocampal neurogenesis in aged mice Journal of Neuroscience 25 8680 8685 10.1523/JNEUROSCI.1731-05.2005 16177036 (Pubitemid 41362045)
91. MP Vawter WJ Freed JE Kleinman 2000 Neuropathology of bipolar disorder Biological Psychiatry 48 486 504 10.1016/S0006-3223(00)00978-1 1:CAS:528:DC%2BD3cXmslKqt7o%3D 11018222 (Pubitemid 30702475)
92. S Vaynman Z Ying F Gomez-Pinilla 2003 Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity Neuroscience 122 647 657 10.1016/j.neuroscience.2003.08.001 1:CAS:528:DC%2BD3sXovVWgsrk%3D 14622908 (Pubitemid 37410286)
93. S Vaynman Z Ying F Gomez-Pinilla 2004 Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition The European Journal of Neuroscience 20 2580 2590 10.1111/j.1460-9568.2004.03720.x 15548201 (Pubitemid 39573773)
94. I Villegas AR Martin W Toma CA de la Lastra 2004 Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: Role of oxygen free radicals generation European Journal of Pharmacology 505 195 203 10.1016/j.ejphar.2004. 10.020 1:CAS:528:DC%2BD2cXhtVWjsLfF 15556153 (Pubitemid 39535692)
95. J Weuve JH Kang JE Manson MM Breteler JH Ware F Grodstein 2004 Physical activity, including walking, and cognitive function in older women Jama 292 1454 1461 10.1001/jama.292.12.1454 1:CAS:528:DC%2BD2cXnvFGit7w%3D 15383516 (Pubitemid 39258338)
96. RM Wightman DL Robinson 2002 Transient changes in mesolimbic dopamine and their association with 'reward' Journal of Neurochemistry 82 721 735 10.1046/j.1471-4159.2002.01005.x 1:CAS:528:DC%2BD38XmsF2htb4%3D 12358778 (Pubitemid 34898824)
97. P Willner R Muscat G Phillips 1991 The role of dopamine in rewarded behavior: Ability, insight, drive or incentive? Polish Journal of Pharmacology and Pharmacy 43 291 300 1:CAS:528:DyaK38Xht1SqsLs%3D 1811221
98. WM Wilson CA Marsden 1996 In vivo measurement of extracellular serotonin in the ventral hippocampus during treadmill running Behavioural Pharmacology 7 101 104 10.1097/00008877-199601000-00011 1:CAS:528:DyaK28Xhs1emtrw%3D 11224400
99. KR Wilund 2007 Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease? Clinical Science (London) 112 543 555 1:CAS:528:DC%2BD2sXkslCktrw%3D
100. LT Young JJ Warsh SJ Kish K Shannak O Hornykeiwicz 1994 Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder Biological Psychiatry 35 121 127 10.1016/0006-3223(94)91201-7 1:STN:280:DyaK2c3itVGmsg%3D%3D 7513191 (Pubitemid 24084128)
101. PX Yuan LD Huang YM Jiang JS Gutkind HK Manji G Chen 2001 The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth The Journal of Biological Chemistry 276 31674 31683 10.1074/jbc.M104309200 1:CAS:528:DC%2BD3MXms1Smsro%3D 11418608