Transient changes in mesolimbic dopamine and their association with 'reward'

Journal of Neurochemistry

Volumn 82, Issue 4, 2002, Pages 721-735

  Wightman, R Mark ^a   Robinson, Donita L ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

Dopamine; Fast scan cyclic voltammetry; Microdialysis; Phasic firing; Reward; Tonic firing

Indexed keywords

DOPAMINE;

DOPAMINERGIC TRANSMISSION; ELECTROPHYSIOLOGY; FOREBRAIN; HUMAN; MESOLIMBIC DOPAMINERGIC SYSTEM; NEUROCHEMISTRY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; REWARD;

ANIMALS; DOPAMINE; ELECTROCHEMISTRY; EXTRACELLULAR SPACE; HUMANS; LIMBIC SYSTEM; MICRODIALYSIS; MOTIVATION; NEURONS; PRIMATES; RATS; REWARD; SYNAPTIC TRANSMISSION;

EID: 0036678947     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01005.x     Document Type: Review

References (149)

1. Microelectrodes closely approach intact nerve terminals in vivo, while larger devices do not: A study using electrochemistry and electron microscopy
2. A quantitative study on the nigro-neostriatal dopamine neuron system in the rat
3. Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat
4. Subsecond adsorption and desorption of dopamine at carbon-fiber microelectrodes
5. Addiction, dopamine, and the molecular mechanisms of memory
6. What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?
7. Application of in vivo electrochemistry to the measurement of changes in dopamine release during intracranial self-stimulation
8. A critical assessment of electrochemical procedures applied to the measurement of dopamine and its metabolites during drug-induced and species-typical behaviours
9. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats
10. Model for effect of insertion trauma on microdialysis measurements
11. Quantitative evaluation of 5-hydroxytryptamine (serotonin) neuronal release and uptake: An investigation of extrasynaptic transmission
12. Anticipation of rewarding electrical brain stimulation evokes ultrasonic vocalization in rats
13. Microelectrodes for the measurement of catecholamines in biological systems
14. Ultrastructural localization of D1 dopamine receptor immunoreactivity in rat striatonigral neurons and its relation with dopaminergic innervation
15. In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens
16. Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: Variation as a function of lesion size
17. Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
18. An ultrastructural analysis of tissue surrounding a microdialysis probe
19. Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: Comparison with novelty and locomotion
20. Drug addiction as dopamine-dependent associative learning disorder
21. Quantification of the dopamine innervation in adult rat neostriatum
22. On the involvement of a tonic dopamine D2-autoinhibition in the regulation of pulse-to-pulse-evoked dopamine release in the rat striatum in vivo
23. The role of dopamine in intracranial self-stimulation of the ventral tegmental area
24. Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: Effects of diazepam
25. Electrical stimulation of reward sites in the ventral tegmental area increases dopamine transmission in the nucleus accumbens of the rat
26. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: Further characterization and effects of apomorphine and cholecystokinin
27. Firing properties of substantia nigra dopaminergic neurons in freely moving rats
28. Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: An in vivo voltammetric study
29. Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain
30. Real-time measurement of electrically evoked extracellular dopamine in the striatum of freely moving rats
31. Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
32. Rapid chronocoulometric measurements of norepinephrine overflow and clearance in CNS tissues
33. Effects of recording media composition on the responses of Nation-coated carbon fiber microelectrodes measured using high-speed chronoamperometry
34. Nafion-coated electrodes with high selectivity for CNS electrochemistry
35. Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely-moving rats
36. In vivo and in vitro release of dopamine
37. Prolonged and extrasynaptic excitatory action of dopamine mediated by D1 receptors in the rat striatum in vivo
38. In vivo electrochemical detection of catechols in the neostriatum of anesthetized rats: Dopamine or DOPAC?
39. The regulation of dopamine neuron activity as determined by in vivo and in vitro intracellular recordings
40. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
41. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
42. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats
43. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis
44. Dopamine uptake: A review of progress in the last decade
45. Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
46. 6-OHDA-lesions of the nucleus accumbens disrupt the acquisition but not the maintenance of ethanol consumption in the alcohol-preferring P line of rats
47. The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation with special reference to reward-seeking
48. The connections of the dopaminergic system with the striatum in rats and primates: An analysis with respect to the functional and compartmental organization of the striatum
49. 2+ ions during measurements of catecholamine release in slices of rat amygdala with fast-scan cyclic voltammetry
50. Can voltammetric electrodes measure brain extracellular dopamine in the behaving animal? Commentary on Blaha and Phillips', 'A critical assessment of electrochemical procedures applied to the measurement of dopamine and its metabolites during drug-induced and species-typical behaviours'
51. Quantitative microdialysis of neurotransmitters
52. Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
53. Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum
54. pH-dependent processes at Nation-coated carbon-fiber microelectrodes
55. Principles of voltammetry and microelectrode surface states
56. Extracellular dopamine dynamics in rat caudate-putamen during experimenter-delivered and intracranial self-stimulation
57. Voltammetry in brain tissue - A new neurophysiological measurement
58. Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food
59. Heterogeneity of ventral tegmental area neurons: Single-unit recording and iontophoresis in awake, unrestrained rats
60. Fluctuations in nucleus accumbens dopamine during cocaine self-administration behavior: An in vivo electrochemical study
61. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous heroin self-administration in rats
62. Drugs of abuse: Anatomy, pharmacology and function of reward pathways
63. Real time measurement of stimulated dopamine release in the conscious rat using fast cyclic voltammetry: Dopamine release is not observed during intracranial self stimulation
64. Dopaminergic neurons: Simultaneous measurements of dopamine release and single-unit activity during stimulation of the medial forebrain bundle
65. Glutamate regulates the spontaneous and evoked release of dopamine in the rat striatum
66. Mesocorticolimbic dopaminergic neurons functional and regulatory roles
67. Mesocorticolimbic dopaminergic network: Functional and regulatory roles
68. Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies
69. Quantitation of in vivo measurements with carbon fiber microelectrodes
70. Neurophysiological investigation of the basis of the fMRI signal
71. Direct comparison of the response of voltammetry and microdialysis to electrically evoked release of striatal dopamine
72. Stearate-modified carbon paste electrodes for detecting dopamine in vivo: Decrease in selectivity caused by lipids and other surface-active agents
73. In vivo voltammetry - Present electrodes and methods
74. Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltammetry
75. Voltammetric and microdialysis monitoring of brain monoamine neurotransmitter release during sociosexual interactions
76. Localization of brain reinforcement mechanisms: Intracranial self-administration and intracranial place-conditioning studies
77. Improving data acquisition for fast-scan cyclic voltammetry
78. Re-evaluation of the role of dopamine in intracranial self-stimulation using in vivo microdialysis
79. Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle
80. Importance of unpredictability for reward responses in primate dopamine neurons
81. Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli
82. Opioid modulation and sensitization of dopamine release elicited by sexually relevant stimuli: A high speed chronoamperometric study in freely behaving rats
83. Limbic-motor integration
84. Differential effect of self-stimulation on dopamine release and metabolism in the rat medial frontal cortex, nucleus accumbens and striatum studied by in vivo microdialysis
85. Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
86. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
87. Neuronal activity in the ventral tegmental area (VTA) during motivated bar press feeding in the monkey
88. On the significance of brain extracellular uric acid detected with in vivo monitoring techniques: A review
89. Positive reinforcement produced by electrical stimulation of septal area and other regions of the rat brain
90. The oxidation of ascorbic acid at carbon paste electrodes. Modified response following contact with surfactant lipid and brain tissue
91. Burst firing in midbrain dopaminergic neurons
92. The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data
93. Neuroanatomical bases of intracranial self-stimulation: Untangling the Gordian knot
94. Neurochemical correlates of brain-stimulation reward measured by ex vivo and in vivo analyses
95. Increased extracellular dopamine in the nucleus accumbens of the rat elicited by a conditional stimulus for food: An electrochemical study
96. Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum
97. Extrasynaptic release of dopamine in a retinal neuron: Activity dependence and transmitter modulation
98. Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with on-line brain dialysis
99. Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty
100. Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty
101. Is the short-latency dopamine response too short to signal reward error?
102. Ascorbate regulation and its neuroprotective role in the brain
103. Measurement of nanomolar dopamine diffusion using low-noise perfluorinated ionomer coated carbon fiber microelectrodes and high-speed cyclic voltammetry
104. Behavior-relevant changes in nucleus accumbens dopamine transmission elicited by food reinforcement: An electrochemical study in rat
105. Changes in medial prefrontal cortical dopamine levels associated with response-contingent food reward: An electrochemical study in rat
106. Anatomical affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system
107. The neural basis of drug craving: An incentive-sensitization theory of addiction
108. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex
109. Sub-second changes in accumbal dopamine during sexual behavior in male rats
110. Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism
111. Effect of pH and surface functionalities on the cyclic voltammetric responses of carbon-fiber microelectrodes
112. The behavioral neurochemistry of motivation: Methodological and conceptual issues in studies of the dynamic activity of nucleus accumbens dopamine
113. The effects of nucleus accumbens dopamine depletions on continuously reinforced operant responding: Contrasts with the effects of extinction
114. Behavioral functions of nucleus accumbens dopamine: Emperical and conceptual problems with the anbedonia hypothesis
115. Differences in norepinephrine and dopamine neurotransmitter storage systems
116. Predictive reward signal of dopamine neurons
117. A neural substrate of prediction and reward
118. Neuronal basis of intracranial self-stimulation
119. The dopamine hypothesis of reward: Past and current status
120. Responses of ventral tegmental area GABA neurons to brain stimulation reward
121. Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area
122. Uptake of dopamine released by impulse flow in the rat mesolimbic and striatal systems in vivo
123. Regulation of quantal size by presynaptic mechanisms
124. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
125. Response times of carbon fiber microelectrodes to dynamic changes in catecholamine concentration
126. Relationship between subjective effects of cocaine and dopamine transporter occupancy
127. Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
128. Brain microdialysis and its application for the study of animal behaviour
129. Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake
130. Molecular specificity of in vivo electrochemical measurements
131. Real-time characterization of dopamine overflow and uptake in the rat striatum
132. Concentration-dependent actions of stimulated dopamine release on neuronal activity in rat striatum
133. Catecholamine theories of reward: A critical review
134. Neuroleptics and operant behavior: The anhedonia hypothesis
135. Brain neuronal systems mediating reward processes
136. The brain and reward
137. Addictive drugs and brain stimulation reward
138. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats
139. Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration
140. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission
141. Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: An in vivo fast-cyclic voltammetry study
142. Coupled effects of mass transfer and uptake kinetics on in vivo microdialysis of dopamine
143. In vivo voltammetry with removable carbon fibre electrodes in freely-moving mice: Dopamine release during intracranial self-stimulation
144. Patterns of dopamine overflow in mouse nucleus accumbens during intracranial self-stimulation
145. Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: An in vivo microdialysis study in freely moving rats
146. Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation