A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

Biomarkers

Volumn 14, Issue 8, 2009, Pages 572-586

  Andersson, Ulf ^a   Lindberg, Johan ^a   Wang, Shunghuang ^b   Balasubramanian, Raji ^c   Marcusson Ståhl, Maritha ^a   Hannula, Mira ^a   Zeng, Chenhui ^b   Juhasz, Peter J ^b   Kolmert, Johan ^a   Bäckström, Jonas ^a   Nord, Lars ^a   Nilsson, Kerstin ^a   Martin, Steve ^b   Glinghammar, Bjrn ^a   Cederbrant, Karin ^a   Schuppe Koistinen, Ina ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b BG Medicine Inc   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Alanine aminotransferase; Liver injury; Pyruvate; Systems biology; Ximelagatran

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE AMINOTRANSFERASE; BIOLOGICAL MARKER; GLUTAMINE; PROTEIN S; PYRUVIC ACID; VITAMIN D BINDING PROTEIN; XIMELAGATRAN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CYTOTOXICITY; HUMAN; HUMAN CELL CULTURE; IN VITRO STUDY; MAJOR CLINICAL STUDY; METABOLOMICS; MULTIVARIATE ANALYSIS; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; SYSTEMS BIOLOGY; UNIVARIATE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ALANINE TRANSAMINASE; AZETIDINES; BENZYLAMINES; BIOLOGICAL MARKERS; BLOOD PROTEINS; CELLS, CULTURED; CLINICAL TRIALS AS TOPIC; DRUG-INDUCED LIVER INJURY; FEMALE; HEPATOCYTES; HISTOCOMPATIBILITY ANTIGENS; HUMANS; MACROPHAGES; MALE; METABOLOMICS; PROTEOMICS; PYRUVIC ACID; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SYSTEMS BIOLOGY; TUMOR CELLS, CULTURED; VITAMIN D-BINDING PROTEIN;

EID: 72949092649     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/13547500903261354     Document Type: Article

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